Epicutaneous Immunization with Autoantigenic Peptides Induces T Suppressor Cells that Prevent Experimental Allergic Encephalomyelitis

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Infectious immunological tolerance.

1971 • 811 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Multiple sclerosis: a two-stage disease

2001 • 602 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

Certified Professionals

2001 • 533 citations

Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration

2001 • 458 citations

Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen

2001 • 429 citations

Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells

2001 • 392 citations

T Cell Response in Experimental Autoimmune Encephalomyelitis (EAE): Role of Self and Cross-Reactive Antigens in Shaping, Tuning, and Regulating the Autopathogenic T Cell Repertoire

2002 • 371 citations

CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations

2000 • 334 citations

Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis

1998 • 299 citations

Mechanisms of Immune Injury in Multiple Sclerosis

1996 • 242 citations

Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice.

1996 • 185 citations

Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4

2000 • 181 citations

In Situ Tolerance within the Central Nervous System as a Mechanism for Preventing Autoimmunity

2000 • 161 citations

CD4+ T Cells Prevent Spontaneous Experimental Autoimmune Encephalomyelitis in Anti–Myelin Basic Protein T Cell Receptor Transgenic Mice

1998 • 159 citations

Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment

2000 • 153 citations

Langerhans cell migration

2000 • 149 citations

Anergic T cells act as suppressor cellsin vitro andin vivo

1999 • 144 citations

T cells with two functional antigen-specific receptors.

1995 • 119 citations

The contributions of T‐cell anergy to peripheral T‐cell tolerance

2001 • 99 citations

Repertoire Requirements of CD4+ T Cells That Prevent Spontaneous Autoimmune Encephalomyelitis

2000 • 97 citations

Tissue-Specific Up-Regulation of B7-1 Expression and Function During the Course of Murine Relapsing Experimental Autoimmune Encephalomyelitis

1998 • 71 citations

Relapsing and Remitting Experimental Autoimmune Encephalomyelitis in B Cell Deficient Mice

2000 • 58 citations

Organ-specific autoimmunity

1997 • 49 citations

Costimulation via lymphocyte function-associated antigen 1 in the absence of CD28 ligation promotes anergy of naïve CD4⁺T cells

2000 • 45 citations

Tolerance and autoimmunity in TCR transgenic mice specific for myelin basic protein

1999 • 44 citations

Rodent models of experimental allergic encephalomyelitis applied to the study of multiple sclerosis.

1996 • 40 citations

Epicutaneous administration of hapten through patch application augments TH2 responses which can downregulate the elicitation of murine contact hypersensitivity

1999 • 14 citations

Definition of two pathways for generation of suppressor T-cell activity.

1983 • 14 citations

Mechanisms of suppression in the transfer of contact sensitivity. Analysis of an I-J+ molecule required for Ly2 suppressor cell activity.

1983 • 13 citations