The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

1997 • 1,144 citations

Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic islets

1981 • 530 citations

Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin

2000 • 361 citations

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

1999 • 292 citations

Determinants of the selective toxicity of alloxan to the pancreatic B cell.

1982 • 280 citations

Alloxan: history and mechanism of action

1988 • 261 citations

Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury.

1994 • 260 citations

NECROSIS OF ISLETS OF LANGERHANS PRODUCED EXPERIMENTALLY

1943 • 259 citations

Alloxan-induced diabetes—evidence for hydroxyl radical as a cytotoxic intermediate

1976 • 249 citations

Diabetogenic Effect of Streptozotocin in the Rat During the Perinatal Period

1974 • 232 citations

Nitric Oxide Generation during Cellular Metabolization of the Diabetogenic N-Mefhyl-N-Nitroso-Urea Streptozotozin Contributes to Islet Cell DNA Damage

1995 • 227 citations

Streptozocin- and Alloxan-Induced H2O2 Generation and DNA Fragmentation in Pancreatic Islets: H2O2 as Mediator for DNA Fragmentation

1991 • 223 citations

Biochemical Evidence for Nitric Oxide Formation from Streptozotocin in Isolated Pancreatic Islets

1993 • 215 citations

GLUT2 in Pancreatic Islets: Crucial Target Molecule in Diabetes Induced With Multiple Low Doses of Streptozotocin in Mice

1998 • 212 citations

Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro

1979 • 206 citations

Studies on Streptozotocin Diabetes

1976 • 200 citations

Alkylation of DNA in rat tissues following administration of streptozotocin.

1981 • 180 citations

Alloxan toxicity to the pancreatic B-cell

1982 • 162 citations

Glucose Insensitivity and Amino-acid Hypersensitivity of Insulin Release in Rats with Non-insulin-dependent Diabetes: A Study with the Perfused Pancreas

1983 • 136 citations

Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin

1991 • 119 citations

N-Monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets

1996 • 119 citations

Pancreatic B cells possess defense mechanisms against cell-specific toxicity.

1986 • 115 citations

Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro

1997 • 102 citations

Alloxan-induced DNA strand breaks in pancreatic islets. Evidence for H2O2 as an intermediate

1991 • 94 citations

Alloxan in vivo does not only exert deleterious effects on pancreatic B cells.

1998 • 91 citations

Short Term Insulin Treatment Prevents the Diabetogenic Action of Streptozotocin in Rats¹

1997 • 91 citations

Mechanisms of Nicotinamide and Thymidine Protection From Alloxan and Streptozocin Toxicity

1988 • 83 citations

Enhancement by streptozotocin of O⁻₂ radical generation by the xanthine oxidase system of pancreatic β‐cells

1988 • 82 citations

Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro

1983 • 82 citations

Importance of the concentration of ATP in rat pancreatic β cells in the mechanism of streptozotocin-induced cytotoxicity

1990 • 73 citations

Glucose May Induce Cell Death through a Free Radical-Mediated Mechanism

1996 • 71 citations

Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro

1999 • 68 citations

Alloxan Stimulation and Inhibition of Insulin Release from Isolated Rat Islets of Langerhans

1978 • 66 citations

Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alloxan

1996 • 64 citations

Protective Effect of Diltiazem Hydrochloride on the Occurrence of Alloxan- or Streptozotocin-Induced Diabetes in Rats

1992 • 63 citations

Influence of melatonin on free radical‐induced changes in rat pancreatic beta‐cells in vitro

2000 • 62 citations

Potentiating Effects of Combined Usage of Three Sulfonylurea Drugs on the Occurrence of Alloxan Diabetes in Rats

1993 • 61 citations

Glucokinase in pancreatic B-cells and its inhibition by alloxan

1987 • 60 citations

Protective Mechanism of Glucose Against Alloxan-Induced Pancreatic β-Cell Damage

1995 • 59 citations

Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by Streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates

1995 • 57 citations

Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis

1994 • 57 citations

Protection by Thymidine, an Inhibitor of Polyadenosine Diphosphate Ribosylation, of Streptozotocin Inhibition of Insulin Secretion*

1987 • 43 citations

Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats.

1992 • 41 citations

Inhibition of glucokinase by alloxan through interaction with SH groups in the sugar-binding site of the enzyme.

1988 • 41 citations

Analysis of Oxygen Radical Toxicity in Pancreatic Islets at the Single Cell Level

1994 • 40 citations

Alloxan cytotoxicity involves lysosomal damage

1992 • 39 citations

The bioelectrical properties of pancreatic islet cells: Effect of diabetogenic agents

1972 • 36 citations

Uptake of Labeled Alloxan in Mouse Organs and Mitochondriain Vivoandin Vitro*

1983 • 35 citations

Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats.

1990 • 35 citations

Protective action by hemin against interleukin-1β induced inhibition of rat pancreatic islet function

1994 • 32 citations

Allopurinol protects pancreatic .BETA. cells from the cytotoxic effect of streptozotocin: In vitro study.

1990 • 30 citations

Alloxan stimulation and subsequent inhibition of insulin release from in situ perfused rat pancreas.

1996 • 30 citations

Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against streptozotocin-induced diabetes

1985 • 30 citations

Protection by 3-aminobenzamide and nicotinamide against streptozotocin-induced beta-cell toxicity in vivo and in vitro.

1990 • 29 citations

Alloxan-induced luminol luminescence as a tool for investigating mechanisms of radical-mediated diabetogenicity

1981 • 28 citations

Glucose Transporter 2 Expression: Prevention of Streptozotocin-Induced Reduction in Beta-Cells With 5-Thio-D-Glucose

2009 • 27 citations

Alloxan-glucose interaction: Effect on incorporation of14C-leucine into pancreatic islets of rat

1980 • 25 citations

Alloxan toxicity in isolated rat hepatocytes and protection by sugars

1982 • 23 citations

Effects of alloxan and streptozotocin on calcium transport in isolated mouse liver mitochondria

1982 • 19 citations

Effect of Ferritin on .LAMBDA.DNA Strand Breaks in the Reaction System of Alloxan Plus NADPH-Cytochrome P450 Reductase: Ferritin's Role in Diabetogenic Action of Alloxan.

1995 • 18 citations

Contrasting modes of action of d-glucose and 3-O-methyl-d-glucose as protectors of the rat pancreatic B-cell against alloxan

1983 • 15 citations

Inhibitory effect of glutathione on the generation of hydroxyl radicals in the reaction system of glutathione-alloxan.

1991 • 15 citations

Severe hyperglycaemia caused by autoimmunization to ? cells in rats

1984 • 14 citations

Uptake of nicotinamide by rat pancreatic β cells with regard to streptozotocin action

1991 • 12 citations

Effects of alloxan and ninhydrin on mitochondrial Ca2+ transport

1992 • 11 citations

INHIBITION OF GLUCOKINASE AND HEXOKINASE FROM PANCREATIC B-CELLS AND LIVER BY ALLOXAN, ALLOXANTIN, DIALURIC ACID, AND t-BUTYLHYDROPEROXIDE

1991 • 10 citations

Lipolysis induced by alloxan in rat adipocytes is not inhibited by insulin.

1999 • 9 citations

Effect of diethyldithiocarbamate on diabetogenic action of alloxan in rats

1993 • 6 citations

Cytotoxic effects of alloxan treatment in vitro on monolayer cultures of neonatal rat pancreas

1983 • 5 citations

Deleted Work

1955 • 0 citations