Transcriptional Regulation of Type I Diabetes by NF-κB

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

1976 • 972 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

Dendritic Cell Development and Survival Require Distinct NF-κB Subunits

2002 • 395 citations

A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells

2001 • 302 citations

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

2000 • 301 citations

NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

1997 • 296 citations

Rel/NF-kappaB/IkappaB proteins and cancer.

1996 • 281 citations

Mouse models of insulin dependent diabetes: Low‐dose streptozocin‐induced diabetes and nonobese diabetic (NOD) mice

1987 • 246 citations

Autoimmune diabetes mellitus in the BB rat

1992 • 223 citations

Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

2002 • 193 citations

C-Rel Regulates Interleukin 12 P70 Expression in Cd8+ Dendritic Cells by Specifically Inducing p35 Gene Transcription

2001 • 178 citations

c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function

1999 • 172 citations

Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

2002 • 168 citations

Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event

2001 • 164 citations

Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice:roles of NF-kappa B in the activation and differentiation of autoreactive T cells.

1999 • 163 citations

Effector Mechanisms in Low‐Dose Streptozotocin‐induced Diabetes

1997 • 162 citations

Low-Dose Streptozocin-Induced Diabetes in Mice: Electron Microscopy Reveals Single-Cell Insulitis Before Diabetes Onset

1988 • 151 citations

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.

1996 • 147 citations

Experimental Autoimmune Encephalomyelitis in NF-κB- Deficient Mice: Roles of NF-κB in the Activation and Differentiation of Autoreactive T Cells

1999 • 137 citations

Prevention of Autoimmune Diabetes With Nonactivating Anti-CD3 Monoclonal Antibody

1992 • 132 citations

c-Rel is essential for B lymphocyte survival and cell cycle progression

1998 • 131 citations

Nitric oxide generation from streptozotocin ¹

1994 • 119 citations

PREVENTION OF TYPE 1 DIABETES

1998 • 67 citations

Treatment With Anti-T-Lymphocyte Antibodies Prevents Induction of Insulitis in Mice Given Multiple Doses of Streptozocin

1987 • 62 citations

Alpha-Phenyl-tert-butylnitrone (PBN) inhibits NFκB activation offering protection against chemically induced diabetes

2000 • 61 citations

NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes

2002 • 58 citations

Immunologic Studies on the Induction of Diabetes in Experimental Animals: Cellular Basis for the Induction of Diabetes by Streptozotocin

1984 • 48 citations

Induction of tolerance to autoimmune diabetes with islet antigens.

1992 • 48 citations

Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody

1992 • 36 citations

Generation of Nitric Oxide from Streptozotocin (STZ) in the Presence of Copper(II) plus Ascorbate: Implication for the Development of STZ-Induced Diabetes

1998 • 35 citations

PASSIVE TRANSFER OF STREPTOZOTOCIN INDUCED DIABETES MELLITUS WITH SPLEEN CELLS

1977 • 32 citations

Low-dose streptozocin-induced diabetes in mice. Electron microscopy reveals single-cell insulitis before diabetes onset

1988 • 32 citations

Immunologic studies on the induction of diabetes in experimental animals. Cellular basis for the induction of diabetes by streptozotocin

1984 • 18 citations

Treatment with anti-T-lymphocyte antibodies prevents induction of insulitis in mice given multiple doses of streptozocin

1987 • 13 citations