Public, private and non-specific antibodies induced by non-cytopathic viral infections

Antibody neutralization and escape by HIV-1

2003 • 2,384 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells

2002 • 1,305 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

HIV vaccine design and the neutralizing antibody problem

2004 • 778 citations

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

2000 • 693 citations

Quantifying the uncertainty in forecasts of anthropogenic climate change

2000 • 652 citations

Molecular Mechanisms of Lymphocyte-Mediated Cytotoxicity and Their Role in Immunological Protection and Pathogenesis In Vivo

1996 • 614 citations

Differing Influences of Virus Burden and Immune Activation on Disease Severity in Secondary Dengue‐3 Virus Infections

2002 • 489 citations

HIV-1 Viremia Prevents the Establishment of Interleukin 2–producing HIV-specific Memory CD4+ T Cells Endowed with Proliferative Capacity

2003 • 443 citations

Antibody, Macrophages, Dengue Virus Infection, Shock, and Hemorrhage: A Pathogenetic Cascade

1989 • 435 citations

SAP is required for generating long-term humoral immunity

2003 • 419 citations

Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses

1994 • 411 citations

Subtypes, Genotypes and Molecular Epidemiology of the Hepatitis B Virus as Reflected by Sequence Variability of the S-Gene

1995 • 409 citations

Microevolution and virulence of dengue viruses

2003 • 396 citations

T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock

2000 • 392 citations

HIV and autoimmunity

2002 • 369 citations

Relationship of Preexisting Dengue Virus (DV) Neutralizing Antibody Levels to Viremia and Severity of Disease in a Prospective Cohort Study of DV Infection in Thailand

2004 • 334 citations

Antibody‐dependent enhancement of viral infection: molecular mechanisms and in vivo implications

2003 • 321 citations

Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection

2003 • 305 citations

Ablation of CD8 and CD4 T Cell Responses by High Viral Loads

2003 • 266 citations

Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections

2003 • 225 citations

Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA

1995 • 208 citations

GENERATION OF DIVERSITY IN RETROVIRUSES

1990 • 197 citations

Critical Role for Alpha/Beta and Gamma Interferons in Persistence of Lymphocytic Choriomeningitis Virus by Clonal Exhaustion of Cytotoxic T Cells

2001 • 177 citations

Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV)

2003 • 155 citations

Complement-Independent, Peroxide-Induced Antibody Lysis of Platelets in HIV-1-Related Immune Thrombocytopenia

2001 • 154 citations

Viral persistencein vivothrough selection of neutralizing antibody-escape variants

2000 • 147 citations

Molecular indetermination in the transition to error catastrophe: Systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity

2002 • 141 citations

Disrupting T-cell homeostasis: how HIV-1 infection causes disease.

2003 • 136 citations

Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells.

1993 • 134 citations

Progressive Reversion of Human Immunodeficiency Virus Type 1 Resistance Mutations In Vivo after Transmission of a Multiply Drug-Resistant Virus

2003 • 123 citations

Genetic Subtypes, Humoral Immunity, and Human Immunodeficiency Virus Type 1 Vaccine Development

2001 • 119 citations

Dengue virus, a flavivirus, propagates in human bone marrow progenitors and hematopoietic cell lines [see comments]

1989 • 100 citations

Dengue virus, a flavivirus, propagates in human bone marrow progenitors and hematopoietic cell lines [see comments]

1989 • 95 citations

Impairment of Cd4+ T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants

2001 • 91 citations

Do escape mutants explain rapid increases in dengue casefatality rates within epidemics?

2000 • 88 citations

Cooperation of B cells and T cells is required for survival of mice infected with vesicular stomatitis virus

1997 • 83 citations

Virus-Induced Immune Complex Disease: Identification of Specific Viral Antigens and Antibodies Deposited in Complexes during Chronic Lymphocytic Choriomeningitis Virus Infection

1978 • 70 citations

Maintenance of memory CTL responses by T helper cells and CD40‐CD40 ligand: antibodies provide the key

2004 • 68 citations

Predicted and inferred waiting times for key mutations in the germinal centre reaction: Evidence for stochasticity in selection

1998 • 65 citations

Autoantibodies in chronic pulmonary tuberculosis

1970 • 53 citations

Involvement of CD4+Cells in Lymphocytic Choriomeningitis Virus-Induced Autoimmune Anaemia and Hypergammaglobulinaemia

1994 • 52 citations

Enhanced Virus Clearance by Early Inducible Lymphocytic Choriomeningitis Virus-Neutralizing Antibodies in Immunoglobulin-Transgenic Mice

1998 • 50 citations

Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques

2002 • 49 citations

The differentiation state of monocytic cells affects their susceptibility to infection and the effects of infection by dengue virus

1994 • 47 citations

Polyclonal B-Lymphocyte Stimulation in Human Malaria and its Association with Ongoing Parasitemia

1991 • 47 citations

Potent Cross‐Group Neutralization of Primary Human Immunodeficiency Virus Isolates with Monoclonal Antibodies—Implications for Acquired Immunodeficiency Syndrome Vaccine

2004 • 46 citations

Immunity to hepatitis C virus: stunned but not defeated

2002 • 43 citations

Virus population dynamics, fitness variations and the control of viral disease: an update

2001 • 41 citations

A longitudinal assessment of autologous neutralizing antibodies in children perinatally infected with human immunodeficiency virus type 1

2003 • 41 citations

Meningitis Caused by Haemophilus influenzae in Infant Rats: Protective Immunity and Antibody Priming by Gastrointestinal Colonization with Escherichia coli

1979 • 40 citations

Antibody prevents the establishment of persistent arenavirus infection in synergy with endogenous T cells

1997 • 38 citations

Control of Lymphocytic Choriomeningitis Virus Infection in Granzyme B Deficient Mice

2002 • 37 citations

Do not underestimate the power of antibodies—lessons from adoptive transfer of antibodies against HIV

2002 • 35 citations

Immunity, immunopathology and vaccines against HIV?

2002 • 26 citations

Competitive Coexistence in Antiviral Immunity

2000 • 25 citations

Why are there so few key mutant clones? The influence of stochastic selection and blocking on affinity maturation in the germinal center

2003 • 23 citations

Public versus personal serotypes of a viral quasispecies

2003 • 22 citations

Antibodies against the two serotypes of vesicular stomatitis virus measured by enzyme-linked immunosorbent assay: immunodominance of serotype-specific determinants and induction of asymmetrically cross-reactive antibodies

1987 • 18 citations

Infection of C3HeB/FeJ mice with the docile strain of lymphocytic choriomeningitis virus induces autoantibodies specific for erythrocyte Band 3

1997 • 15 citations

Evolution and Polymorphism of Poliovirus Genomes

1993 • 12 citations

Oligoclonal immunoglobulin bands in serum in association with chronic viral hepatitis.

1990 • 11 citations

Hepatitis C virus: Clades and properties

2002 • 10 citations

Resistance to Neutralizing Antibody and Expanded Coreceptor Usage Are Associated with Human Immunodeficiency Virus Type 1 Isolates Derived from Chimpanzees with Pathogenic Infections

2001 • 2 citations

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1993 • 1 citations

Persistent virus infections in studies of the immune response.

1991 • 1 citations

[Immune complex disease of mice persistently infected with lymphocytic choriomeningitis (LCM) virus].

1981 • 1 citations