Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

Vascular-specific growth factors and blood vessel formation

2000 • 3,667 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Permanent cell line expressing human factor VIII-related antigen established by hybridization.

1983 • 1,458 citations

HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line

1992 • 1,258 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

2001 • 816 citations

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

1995 • 546 citations

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

1995 • 517 citations

Angiopoietin-1 induces sprouting angiogenesis in vitro

1998 • 467 citations

Tie receptors: new modulators of angiogenic and lymphangiogenic responses

2001 • 412 citations

The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism

2005 • 367 citations

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.

1992 • 351 citations

Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2

2001 • 289 citations

Direct Cell Adhesion to the Angiopoietins Mediated by Integrins

2001 • 262 citations

Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis

2000 • 254 citations

COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity

2004 • 251 citations

Bivalence of EGF-like ligands drives the ErbB signaling network

1997 • 226 citations

Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt

1998 • 222 citations

Biological characterization of angiopoietin‐3 and angiopoietin‐4

2004 • 169 citations

Functional Significance of Tie2 Signaling in the Adult Vasculature

2004 • 166 citations

Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development

1999 • 159 citations

Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis

2004 • 142 citations

The mouse tie receptor tyrosine kinase gene: expression during embryonic angiogenesis.

1994 • 139 citations

Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis

2003 • 136 citations

Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization

1992 • 132 citations

The Bmx Tyrosine Kinase Induces Activation of the Stat Signaling Pathway, Which Is Specifically Inhibited by Protein Kinase Cδ

1997 • 112 citations

A Novel Endothelial Cell Surface Receptor Tyrosine Kinase with Extracellular Epidermal Growth Factor Homology Domains

1992 • 112 citations

Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas.

1994 • 112 citations

Expression and Function of Murine Receptor Tyrosine Kinases, TIE and TEK, in Hematopoietic Stem Cells

1997 • 109 citations

The Endothelial Receptor Tyrosine Kinase Tie1 Activates Phosphatidylinositol 3-Kinase and Akt To Inhibit Apoptosis

2002 • 103 citations

Evidence for Heterotypic Interaction between the Receptor Tyrosine Kinases TIE-1 and TIE-2

2000 • 93 citations

Functions of Tie1 and Tie2 Receptor Tyrosine Kinases in Vascular Development

1999 • 77 citations

Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy.

2001 • 77 citations

Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells

1996 • 68 citations

Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells

1996 • 56 citations