Translational dynamics

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

1987 • 1,153 citations

Structure, Function, and Genetics of Ribosomes

1986 • 852 citations

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

1981 • 807 citations

STRUCTURE OF RIBOSOMAL RNA

1984 • 793 citations

Kinetic amplification of enzyme discrimination

1975 • 742 citations

Intermediate states in the movement of transfer RNA in the ribosome

1989 • 736 citations

Comparative Anatomy of 16-S-like Ribosomal RNA

1985 • 689 citations

Secretory protein translocation across membranes—the role of the ‘docking protein’

1982 • 648 citations

Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 644 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

GTP-binding domain: three consensus sequence elements with distinct spacing.

1987 • 602 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites

1989 • 492 citations

Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA

1988 • 488 citations

The Structure and Function of Eukaryotic Ribosomes

1979 • 468 citations

Ribosome pausing and stacking during translation of a eukaryotic mRNA.

1988 • 468 citations

Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation

1988 • 447 citations

The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.

1978 • 436 citations

Transfer RNA shields specific nucleotides in 16S ribosomal RNA from attack by chemical probes

1986 • 425 citations

The frequency of errors in protein biosynthesis

1972 • 396 citations

Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.

1985 • 396 citations

Secondary structure model for 23S ribosomal RNA

1981 • 373 citations

Initiation of protein synthesis in mammalian cells

1986 • 359 citations

Initiation of mammalian protein synthesis

1977 • 337 citations

ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products.

1980 • 323 citations

CONTROLLED PROTEOLYSIS OF NASCENT POLYPEPTIDES IN RAT LIVER CELL FRACTIONS

1970 • 320 citations

CONTROLLED PROTEOLYSIS OF NASCENT POLYPEPTIDES IN RAT LIVER CELL FRACTIONS

1970 • 301 citations

The site of action of alpha-sarcin on eukaryotic ribosomes. The sequence at the alpha-sarcin cleavage site in 28 S ribosomal ribonucleic acid.

1982 • 299 citations

RNA-Protein Interactions in 30 S Ribosomal Subunits: Folding and Function of 16 S rRNA

1989 • 292 citations

Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes

1978 • 281 citations

Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly.

1987 • 281 citations

Cap recognition and the entry of mRNA into the protein synthesis initiation cycle

1988 • 256 citations

CHARACTERIZATION OF A RIBOSOME-LINKED GUANOSINE TRIPHOSPHATASE IN ESCHERICHIA COLI EXTRACTS

1964 • 245 citations

The functional role of ribosomal RNA in protein synthesis

1989 • 238 citations

Regulation of protein synthesis initiation in eucaryotes

1983 • 227 citations

Hyper-accurate ribosomes inhibit growth.

1984 • 211 citations

Covalent crosslinking of tRNA1Val to 16S RNA at the ribosomal P site: identification of crosslinked residues.

1982 • 203 citations

Primary structure of elongation factor Tu from Escherichia coli.

1980 • 197 citations

Content of elongation factor Tu in Escherichia coli.

1975 • 185 citations

The ribonuclease activity of the cytotoxin alpha-sarcin. The characteristics of the enzymatic activity of alpha-sarcin with ribosomes and ribonucleic acids as substrates.

1983 • 179 citations

EFTu provides an internal kinetic standard for translational accuracy

1988 • 176 citations

The primary structure of the α subunit of human elongation factor 1

1986 • 173 citations

Ribosomal-membrane interaction: In vitro binding of ribosomes to microsomal membranes

1974 • 170 citations

Binding of transfer ribonucleic acid to ribosomes engaged in protein synthesis: Number and properties of ribosomal binding sites

1965 • 169 citations

Studies on the Formation of Transfer Ribonucleic Acid-Ribosome Complexes

1969 • 156 citations

Mechanism of ribosomal subunit association: Discrimination of specific sites in 16 S RNA essential for association activity

1979 • 151 citations

Nascent polypeptide chains emerge from the exit domain of the large ribosomal subunit: immune mapping of the nascent chain.

1982 • 142 citations

Proteins of rough microsomal membranes related to ribosome binding. II. Cross-linking of bound ribosomes to specific membrane proteins exposed at the binding sites

1978 • 142 citations

Amino acid sequence of mammalian elongation factor 2 deduced from the cDNA sequence: homology with GTP-binding proteins.

1986 • 141 citations

Identification of a site on 23S ribosomal RNA located at the peptidyl transferase center.

1984 • 141 citations

EVOLVING RIBOSOME STRUCTURE: DOMAINS IN ARCHAEBACTERIA, EUBACTERIA, EOCYTES AND EUKARYOTES

1985 • 140 citations

Polypeptide chain elongation factor 1 alpha (EF-1 alpha) from yeast: nucleotide sequence of one of the two genes for EF-1 alpha from Saccharomyces cerevisiae.

1984 • 140 citations

The Role of Eucaryotic Elongation Factor Tu in Protein Synthesis

1980 • 137 citations

Location of exit channel for nascent protein in 80S ribosome

1986 • 136 citations

tRNA, SUPPRESSION, AND THE CODE

1985 • 134 citations

Topography and stoichiometry of acidic proteins in large ribosomal subunits from Artemia salina as determined by crosslinking.

1987 • 131 citations

Rapid activation of calmodulin-dependent protein kinase III in mitogen-stimulated human fibroblasts. Correlation with intracellular Ca2+ transients.

1987 • 129 citations

The allosteric three-site model for the ribosomal elongation cycle

1989 • 126 citations

Mutations in elongation factor EF-1 alpha affect the frequency of frameshifting and amino acid misincorporation in Saccharomyces cerevisiae.

1988 • 125 citations

A Model of the Functioning Ribosome: Locking and Unlocking of the Ribosome Subparticles

1969 • 124 citations

Guanine nucleotides, protein phosphorylation and the control of translation

1986 • 124 citations

Characterization of secretory protein translocation: ribosome-membrane interaction in endoplasmic reticulum.

1986 • 121 citations

Peptide chain termination

1980 • 120 citations

Binding of the 3′ terminus of tRNA to 23S rRNA in the ribosomal exit site actively promotes translocation.

1989 • 119 citations

SUF12 suppressor protein of yeast

1988 • 118 citations

Elongation factor 1βγ from Artemia

1988 • 117 citations

Labeling the peptidyltransferase center of the Escherichia coli ribosome with photoreactive tRNA(Phe) derivatives containing azidoadenosine at the 3' end of the acceptor arm: a model of the tRNA-ribosome complex.

1989 • 116 citations

A model for the spatial arrangement of the proteins in the large subunit of the Escherichia coli ribosome.

1988 • 115 citations

Characterization of reticulocyte release factor.

1977 • 110 citations

tRNA-tRNA interactions within cellular ribosomes.

1989 • 110 citations

Structure and function of free 40 S ribosome subunits: Characterization of initiation factors

1975 • 106 citations

Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation

1979 • 106 citations

Initiation of mammalian protein synthesis The multiple functions of the initiation factor eIF-3

1979 • 105 citations

Structure and expression of elongation factor 1α in tomato

1989 • 105 citations

The primary structure of elongation factor EF-1 alpha from the brine shrimp Artemia.

1984 • 103 citations

An estimate of the global error frequency in translation

1982 • 99 citations

The activity of the acidic phosphoproteins from the 80 S rat liver ribosome.

1982 • 97 citations

Role of 5S RNA in the Functions of 50S Ribosomal Subunits

1971 • 96 citations

tRNA binding sites of ribosomes from Escherichia coli

1984 • 94 citations

Distance moved by transfer RNA during translocation from the A site to the P site on the ribosome

1982 • 91 citations

Localization of the elongation factor g on escherichia coli ribosome

1981 • 90 citations

Crosslinking of initiation factor eIF‐2 to proteins of the small subunit of rat liver ribosomes

1979 • 89 citations

Identification by affinity chromatography of the eukaryotic ribosomal proteins that bind to 5 S ribosomal ribonucleic acid.

1978 • 89 citations

The nucleotide sequence of theEscherichta coli fusgene, coding for elongation factor G

1984 • 88 citations

Identification by RNA-protein cross-linking of ribosomal proteins located at the interface between the small and the large subunits of mammalian ribosomes.

1982 • 88 citations

Mutation at position 791 in Escherichia coli 16S ribosomal RNA affects processes involved in the initiation of protein synthesis.

1989 • 88 citations

A ribosome-dependent GTPase from yeast distinct from elongation factor 2.

1976 • 86 citations

The mechanism of action of the cytotoxic nuclease α-sarcin and its use to analyse ribosome structure

1984 • 86 citations

Mammalian Peptide Chain Termination, II. Codon Specificity and GTPase Activity of Release Factor

1971 • 86 citations

Phosphorylation of elongation factor 1 beta by an endogenous kinase affects its catalytic nucleotide exchange activity.

1988 • 86 citations

Posttranslational modification of elongation factor 2 in diphtheria-toxin-resistant mutants of CHO-K1 cells.

1980 • 85 citations

Strategies for efficiency and accuracy in gene expression

1987 • 84 citations

Characterization of Developmentally Regulated Forms of Elongation Factor 1 in Artemia salina

1976 • 82 citations

Mutants of the elongation factor EF-Tu, a new class of nonsense suppressors.

1985 • 82 citations

Structural dynamics of bacterial ribosomes

1976 • 79 citations

Protein synthesis in yeast. I. Purification and properties of elongation factor 3 from Saccharomyces cerevisiae.

1981 • 77 citations

Distribution of RNA and protein in crystalline eukaryotic ribosomes

1982 • 77 citations

A purified complex from Xenopus oocytes contains a p47 protein, an in vivo substrate of MPF, and a p30 protein respectively homologous to elongation factors EF‐1γ and EF‐1β

1989 • 76 citations

Fluorescence of the Y base of yeast phenylalanine transfer ribonucleic acid. Effect of pH, aminoacylation, and interaction with elongation factor Tu

1973 • 75 citations

Role of yeast elongation factor 3 in the elongation cycle

1989 • 74 citations

The Requirement for Ribosomal Proteins L7 and L12 in Peptide-Chain Termination

1974 • 74 citations

Localization of elongation factor Tu on the ribosome

1986 • 72 citations

Dissimilarity in protein chain elongation factor requirements between yeast and rat liver ribosomes.

1977 • 72 citations

A GTPase reaction accompanying the rejection of Leu-tRNA2 by UUU-programmed ribosomes. Proofreading of the codon-anticodon interaction by ribosomes.

1981 • 72 citations

Crosslinking of eukaryotic initiation factor eIF3 to the 40S ribosomal subunit from rabbit reticulocytes

1983 • 71 citations

Multiple forms and some properties of aminoacyltransferase I (elongation factor 1) from rat liver

1972 • 71 citations

Murine Elongation Factor 1α (EF-1α) Is Posttranslationally Modified by Novel Amide-linked Ethanolamine-phosphoglycerol Moieties

1989 • 70 citations

Complete Sequence of the Coding Region of Human Elongation Factor 2 (EF-2) by Enzymatic Amplification of cDNA from Human Ovarian Granulosa Cells

1989 • 70 citations

Nerve growth factor treatment or cAMP elevation reduces Ca2+/calmodulin-dependent protein kinase III activity in PC12 cells.

1987 • 70 citations

Site-directed mutagenesis of Escherichia coli 23 S Ribosomal RNA at position 1067 within the GTP hydrolysis centre

1988 • 69 citations

The Interaction of Aminoacyl Transferase II and Ribosomes

1966 • 67 citations

Purification of various forms of elongation factor 1 from rabbit reticulocytes

1984 • 67 citations

Aminoacyltransferase II from Rat Liver

1971 • 67 citations

In Vitro Synthesis, Phosphorylation, and Localization on 48 S Initiation Complexes of Human Protein Synthesis Initiation Factor 4E

1989 • 67 citations

Protein topography of the 40 S ribosomal subunit from rabbit reticulocytes shown by cross-linking with 2-iminothiolane.

1981 • 66 citations

Purification and Properties of an Elongation Factor Functionally Analogous to Bacterial Elongation Factor Ts from Embryos of Artemia salina

1978 • 65 citations

Cross-linking of elongation factor 2 to rat-liver ribosomal proteins by 2-iminothiolane

1986 • 64 citations

Cross-linking of tRNA at two different sites of the elongation factor Tu.

1984 • 63 citations

Cross-linking of Met-tRNA_fto eIF-2β and to the ribosomal proteins S3a and S6 within the eukaryotic initiation complex, eIF-2-GMPPCP Met-tRNA_f-small ribosomal subunit

1981 • 62 citations

Methylation of elongation factor 1 alpha from the fungus Mucor.

1982 • 62 citations

Differences between the protein moieties of active subunits and EDTA-treated subunits of rat liver ribosomes with specific references to A 5 S rRNA · protein complex

1975 • 61 citations

Signal recognition particle arrests elongation of nascent secretory and membrane proteins at multiple sites in a transient manner.

1987 • 61 citations

New low resolution model for 50S subunit of Escherichia coli ribosomes.

1976 • 60 citations

Biosynthetic incorporation of [3H]ethanolamine into protein synthesis elongation factor 1α reveals a new post-translational protein modification

1989 • 60 citations

Changes in form of elongation factor during development of Artemia salina

1975 • 59 citations

Decline in synthesis of elongation factor one (EF-1) precedes the decreased synthesis of total protein in aging Drosophila melanogaster

1983 • 59 citations

Location of eight ribosomal proteins on the surface of the 50S subunit from Escherichia coli.

1983 • 58 citations

The Binding of Tritiated Elongation Factors 1 and 2 to Ribosomes from Krebs II Mouse Ascites Tumor Cells

1975 • 57 citations

Endogenous ADP-ribosylation of elongation factor 2 in polyoma virus-transformed baby hamster kidney cells.

1989 • 57 citations

Identification of a histidine residue near the aminoacyl transfer ribonucleic acid binding site of elongation factor Tu

1981 • 56 citations

Ribosomal proteins L1, L17 and L27 from Escherichia coli localized at single sites on the large subunit by immune electron microscopy

1981 • 56 citations

The spatial arrangement of the complex between eukaryotic initiation factor eIF-3 and 40 S ribosomal subunit. Cross-linking between factor and ribosomal proteins

1983 • 56 citations

Further studies on the interactions of elongation factor 1 from animal tissues

1973 • 55 citations

Mechanism of ribosomal translocation

1987 • 55 citations

Cross-linking of mRNA to initiation factor eIF-3, 24 kDa cap binding protein and ribosomal proteins SI, S3/3a, S6 and S11 within the 48S pre-initiation complex

1984 • 55 citations

The mechanism of the protein‐synthesis elongation cycle in eukaryotes

1986 • 54 citations

ATPase and GTPase Activities Isolated from Rat Liver Ribosomes

1974 • 54 citations

Regulation of protein synthesis factor EF-1 alpha in Mucor racemosus.

1985 • 54 citations

Presence in many mammalian tissues of an identical major cytosolic substrate (M_r 100000) for calmodulin‐dependent protein kinase

1983 • 54 citations

The Sequence of Reactions leading to the Synthesis of a Peptide Bond on Reticulocyte Ribosomes

1969 • 54 citations

Sequence homology between EF‐1α, the α‐chain of elongation factor 1 from Artemia salina and elongation factor EF‐TU from Escherichia coli

1983 • 53 citations

Highly frequent single amino acid substitution in mammalian elongation factor 2 (EF-2) results in expression of resistance to EF-2-ADP-ribosylating toxins.

1987 • 53 citations

Proximity of mRNA5′-region and 18S rRNA in eukaryotic initiation complexes

1980 • 53 citations

Interaction of the low molecular weight form of elongation factor 1 with guanine nucleotides and aminoacyl-tRNA

1976 • 53 citations

Codon–anticodon interaction at the ribosomal peptidyl-site

1979 • 53 citations

Cross-linking study on protein neighborhoods at the subunit interface of rat liver ribosomes with 2-iminothiolane.

1986 • 52 citations

Spontaneous, elongation factor G independent translocation of Escherichia coli ribosomes.

1983 • 52 citations

Biosynthetic labeling of diphthamide in Saccharomyces cerevisiae.

1983 • 52 citations

Ribosomal proteins S3, S6, S8 and S10 of Escherichia coli localized on the external surface of the small subunit by immune electron microscopy

1981 • 51 citations

Interaction of 5-S RNA, 5.8-S RNA and tRNA with Rat-Liver Ribosomal Proteins

1978 • 51 citations

Peptidyl Transferase Center of Rat-Liver Ribosome Cores

1977 • 51 citations

Composition and Properties of Trypsin-Cleaved Elongation Factor Tu

1980 • 50 citations

Identification by affinity chromatography of the eukaryotic ribosomal proteins that bind to 5.8 S ribosomal ribonucleic acid.

1979 • 50 citations

The complete cDNA sequence of mouse elongation factor 1 alpha (EF 1 alpha) mRNA

1989 • 49 citations

Ribosomal Proteins Cross-Linked to Natural mRNA by UV Irradiation of Rat Liver Polysomes1

1981 • 49 citations

Inhibition of peptide chain termination by antibodies specific for ribosomal proteins

1975 • 49 citations

Localization of proteins S1, S2, S16 and S23 on the surface of small subunits of rat liver ribosomes by immune electron microscopy

1979 • 49 citations

Translocation makes the ribosome less compact

1987 • 49 citations

Elongation factor Tu localized on the exterior surface of the small ribosomal subunit

1986 • 48 citations

Nucleotide sequence of the SUF2 frameshift suppressor gene of Saccharomyces cerevisiae.

1982 • 47 citations

Purification and properties of rabbit reticulocyte elongation factor

1976 • 47 citations

Nascent polypeptide chains exit the ribosome in the same relative position in both eucaryotes and procaryotes.

1983 • 46 citations

Direct localization of the tRNA-anticodon interaction site on the Escherichia coli 30 S ribosomal subunit by electron microscopy and computerized image averaging

1988 • 46 citations

Nucleotide sequence of an external transcribed wacer inXenopus laevisrDNA: sequences flanking the 5' and 3' ends of 18S rRNA are non-complementary

1982 • 45 citations

Cross-linking study on protein topography of rat liver 60 S ribosomal subunits with 2-iminothiolane.

1985 • 44 citations

Ribosome structure and protein biosynthesis

1987 • 44 citations

The mechanism of action of barley toxin: a type 1 ribosome-inactivating protein with RNA N-glycosidase activity

1988 • 44 citations

Primary structure of elongation factor 1γ fromArtemia

1987 • 44 citations

Specific interaction of one subunit of eukaryotic initiation factor eIF-3 with 18S ribosomal RNA within the binary complex, eIF-3.small ribosomal subunit, as shown by cross-linking experiments

1982 • 44 citations

Joint use of light, x‐ray and neutron scattering for investigation of RNA and protein mutual distribution within the 50S subparticle of E. coli ribosomes

1975 • 43 citations

The emerging three-dimensional structure and function of 16S ribosomal RNA

1988 • 42 citations

Studies on elongation factor II from calf brain

1972 • 42 citations

Conformational Control of the Interaction of Eukaryotic Elongation Factors EF-1 and EF-2 with Ribosomes

1973 • 42 citations

Ribosomal subunit antiassociation activity in rabbit reticulocyte lysates. Evidence for a low molecular weight ribosomal subunit antiassociation protein factor (Mr = 25,000).

1984 • 42 citations

Influence of Guanine Nucleotides and Elongation Factors on Interaction of Release Factors with the Ribosome

1973 • 42 citations

Crosslinking of elongation factor Tu to tRNA^Phe by trans‐diamminedichloroplatinum (II) Characterization of two crosslinking sites on EF‐Tu

1989 • 41 citations

Challenging the three-dimensional structure of ribosomes

1989 • 41 citations

Identification of proteins at the subunit interface of the Escherichia coli ribosome by cross-linking with dimethyl 3,3'-dithiobis(propionimidate)

1981 • 41 citations

Conserved Terminal Sequence in 18S rRNA May Represent Terminator Anticodons

1973 • 41 citations

Covalent cross-linking of poly(A) toEscherichia coliribosomes, and localization of the cross-link site within the 16S RNA

1988 • 40 citations

Localization of the sites of ADP‐ribosylation and GTP binding in the eukaryotic elongation factor EF‐2

1985 • 39 citations

The post-translational trimethylation of diphthamide studied in vitro.

1988 • 38 citations

Reduced ribosomal binding of eukaryotic elongation factor 2 following ADP-ribosylation. Difference in binding selectivity between polyribosomes and reconstituted monoribosomes

1985 • 38 citations

Identification of proteins at the peptidyl-tRNA binding site of rat liver ribosomes

1981 • 38 citations

The histidine residue of codon 715 is essential for function of elongation factor 2

1989 • 38 citations

Effects of Estradiol on Calcium-Specific Protein Phosphorylation in the Rat Corpus Luteum*

1987 • 38 citations

The identification by affinity chromatography of the rat liver ribosomal proteins that bind to elongator and initiator transfer ribonucleic acids.

1980 • 38 citations

A new non-crystallographic image-processing technique reveals the architecture of ribosomes

1988 • 37 citations

Interaction of guanosine nucleotides with elongation factor 2. I. Equilibrium dialysis studies

1975 • 37 citations

Localization of eukaryotic initiation factor 3 on native small ribosomal subunits

1978 • 36 citations

Crosslinking of the anticodon of Escherichia coli and Bacillus subtilis acetylvalyl-tRNA to the ribosomal P site. Characterization of a unique site in both E. coli 16S and yeast 18S ribosomal RNA

1984 • 36 citations

Methylation of elongation factor 1α in mouse 3T3B and 3T3BSV40 cells

1983 • 36 citations

cAMP‐dependent activation of protein synthesis correlates with dephosphorylation of elongation factor 2

1988 • 36 citations

Kinetic determination of the effects of ADP-ribosylation on the interaction of eukaryotic elongation factor 2 with ribosomes.

1990 • 36 citations

Mechanism of translocation: relative arrangement of tRNA and mRNA on the ribosome.

1980 • 36 citations

Decreased rates of protein synthesis by cell-free preparations from different organs of aging mice

1983 • 36 citations

Isolation of the yeast gene encoding elongation factor 3 for protein synthesis.

1987 • 34 citations

Characterization of the elongation factors from calf brain

1986 • 34 citations

A type 2A protein phosphatase dephosphorylates the elongation factor 2 and is stimulated by the phorbol ester TPA in mouse epidermis in vivo

1989 • 34 citations

A neutron study of the 30 S-ribosome subunit and of the 30 S-IF3 complex

1976 • 33 citations

Effect of point mutations in the decoding site (C1400) region of 16S ribosomal RNA on the ability of ribosomes to carry out individual steps of protein synthesis

1989 • 33 citations

The elongation factor G carries a catalytic site for GTP hydrolysis, which is revealed by using 2-propanol in the absence of ribosomes.

1986 • 33 citations

Affinity labeling of proteins at the mRNA binding site of rat liver ribosomes by an analogue of octauridylate containing an alkylating group attached to the 3'‐end

1981 • 33 citations

Primary structure of elongation factor 1β from Artemia

1986 • 33 citations

Characterization of the ribosomal properties required for formation of a GTPase active complex with the eukaryotic elongation factor 2

1989 • 33 citations

Studies on proteins of animal ribosomes. Affinity labeling of rat liver ribosomes by N‐bromoacetylpuromycin

1974 • 33 citations

Splicing of a yeast proline tRNA containing a novel suppressor mutation in the anticodon stem

1986 • 32 citations

Regulation of translation. Analysis of intermediary reactions in protein synthesis in exponentially growing and stationary phase Chinese hamster ovary cells in culture

1980 • 32 citations

Functional and structural studies on a tryptic fragment of eucaryotic elongation factor Tu from rabbit reticulocytes

1981 • 32 citations

Frameshift suppressor mutations affecting the major glycine transfer RNAs of Saccharomyces cerevisiae

1987 • 32 citations

A second tRNA binding site on elongation factor Tu is induced while the factor is bound to the ribosome.

1985 • 32 citations

Eukaryotic elongation factor 2 loses its non‐specific affinity for RNA and leaves polyribosomes as a result of ADP‐ribosylation

1984 • 32 citations

Immunoelectron microscopy of ribosomes carrying a fluorescence label in a defined position

1983 • 31 citations

Structure and expression of elongation factor 2 gene during development of Dictyostelium discoideum

1989 • 31 citations

Partial reassembly of active 60S ribosomal subunits from rat liver following treatment with dimethylmaleic anhydride

1987 • 31 citations

Reduced turnover of the elongation factor EF-1 · ribosome complex after treatment with the protein synthesis inhibitor II from barley seeds

1986 • 30 citations

Interaction of Eukaryote Elongation Factor EF 1 with Guanosine Nucleotides and Aminoacyl-tRNA

1972 • 30 citations

Spatial arrangement of proteins within the small subunit of rat liver ribosomes studied by cross-linking.

1983 • 30 citations

The importance of individual nucleotides for the structure and function of rRNA molecules in E. coli

1986 • 30 citations

Phosphorylation of elongation factor 1 in polyribosome fraction of rabbit reticulocytes

1984 • 30 citations

Affinity labelling of the eukaryotic elongation factor EF-2 with the guanosine nucleotide analogue 5′-p-fluorosulfonylbenzoylguanosine

1984 • 30 citations

Translocation Reaction Promoted by Polypeptide Chain Elongation Factor-2 from Pig Liver

1977 • 30 citations

Identification of proteins of the 40 S ribosomal subunit involved in interaction with initiation factor eIF‐2 in the quaternary initiation complex by means of monospecific antibodies

1988 • 30 citations

Localization of the GTP‐Binding Site in the Ribosome · Elongation‐Factor‐G · GTP Complex

1976 • 29 citations

Photoincorporation of Tetracycline into Rat‐Liver Ribosomes and Subunits

1982 • 29 citations

The Association of Ribosomal Subunits of Escherichia coli

1973 • 29 citations

The α and γ subunits of initiation factor elF-2 can be cross-linked to 18S ribosomal RNA within the quaternary initiation complex, eIF-2-Met-tRNA_fGDPCP small ribosomal subunit

1980 • 29 citations

Crosslinking of proteins to ribosomal RNA in HeLa cell polysomes by sodium periodate

1978 • 29 citations

The ribosomal binding site for eukaryotic elongation factor EF-2 contains 5 S ribosomal RNA

1987 • 29 citations

Are there proteins between the ribosomal subunits?

1986 • 28 citations

Sex-associated Differential Fluorescence of Mudminnow Chromosomes and Spermatozoa

1973 • 28 citations

Elongation Factor 1 from Artemia salina Properties and Disaggregation of the Enzyme

1976 • 27 citations

A ‘swell’ way to regulate metabolism

1990 • 27 citations

Elongation Factor 1 from Krebs II Mouse Ascites Cells. Interaction with Guanosine Nucleotides and Aminoacyl-tRNA

1974 • 27 citations

Quantification of the different ribosomal phases during the translational elongation cycle in rabbit reticulocyte lysates

1984 • 27 citations

Primary structure of rat liver elongation factor 2 deduced from the cDNA sequence

1989 • 26 citations

Recognition of termination codon by release factor in the presence of a tRNA-occupied A site. Evidence for flexibility in accommodation of the release factor on the ribosome.

1983 • 26 citations

Interactions of Elongation Factor 2 (EF‐2) with Guanine Nucleotides and Ribosomes

1980 • 25 citations

A conserved amino acid sequence around Arg−68 of Artemia elongation factor 1α is involved in the binding of guanine nucleotides and aminoacyl transfer RNAs

1987 • 25 citations

Characterisation of the ribosomal binding site for eukaryotic elongation factor 2 by chemical cross-linking

1987 • 25 citations

Structural and functional studies of the interaction of the eukaryotic elongation factor EF‐2 with GTP and ribosomes

1988 • 25 citations

Identification of the tRNA-binding sites on rat liver ribosomes by affinity labeling

1977 • 25 citations

Ricin and α‐sarcin alter the conformation of 60S ribosomal subunits at neighboring but different sites

1988 • 24 citations

Composition of the Escherichia coli 70S ribosomal interface: a crosslinking study

1983 • 24 citations

Variations in the cell‐free translating apparatus of cultured animal cells as a function of time during cell growth

1975 • 24 citations

Binding of tRNA alters the chemical accessibility of nucleotides within the large ribosomal RNAs ofE. coliribosomes

1984 • 24 citations

Cross-linking study on localization of the binding site for elongation factor 1 alpha on rat liver ribosomes.

1986 • 24 citations

Photoaffinity labeling of rat liver ribosomes by phenylalanine‐tRNA N‐Acylated by 2‐nitro‐4‐azidobenzoic acid

1979 • 24 citations

Mechanism of translocation. Binding equilibria between the ribosome, mRNA analogues, and cognate tRNAs.

1982 • 24 citations

Structure of initiation factor eIF‐3 from rat liver

1986 • 24 citations

Ribosomal Translocation Assayed by the Matrix-Bound Poly(uridylic acid) Column Technique. Effects of Different Magnesium Concentrations

1979 • 23 citations

Cross-linking of L5 protein to 5 S RNA in rat liver 60-S subunits by ultraviolet irradiation

1980 • 22 citations

Two-dimensional gel electrophoresis technique for determination of the crosslinked nucleotides in cleavable covalent RNA-RNA complexes. Application to Escherichia coli and Bacillus subtilis acetylvalyl-tRNA covalently linked to E. coli 16 S and yeast 18 S ribosomal RNA

1984 • 21 citations

Shape and location of eukaryotic initiation factor eIF‐2 on the 40s ribosomal subunit of rat liver

1988 • 21 citations

Characterization of the binding of rat liver ribosomal proteins L6, L8, L19, S9, and S13 to 5.8 S ribosomal ribonucleic acid.

1981 • 20 citations

Association of 16S and 23S ribosomal RNAs to form a bimolecular complex.

1983 • 20 citations

Identification of Nsp100 as elongation factor 2 (EF‐2)

1989 • 20 citations

Elongation Factor 1 from Ascites Tumor Cells: Interaction with Ribosomes and Elongation Factor 2

1974 • 19 citations

Nucleotide binding to elongation factor 2 inactivated by diphtheria toxin

1986 • 18 citations

Different conformations of tRNA in the ribosomal P‐site and A‐site

1985 • 18 citations

Effect of tumor promoting phorbol ester TPA on epidermal protein synthesis: Stimulation of an elongation factor 2 phosphatase activity by TPA in vivo

1988 • 17 citations

New aspects of the ribosomal elongation cycle

1984 • 17 citations

Functional interactions in vivo between suppressor tRNA and mutationally altered ribosomal protein S4

1986 • 17 citations

Neighboring proteins in rat liver 60 S ribosomal subunits disulfide-linked by hydrogen peroxide oxidation or cross-linked with dithiobis(succinimidyl propionate).

1985 • 17 citations

On the presence of a dense internal region in the 50 S subparticle of E. coli ribosomes

1970 • 17 citations

Stereochemical Analysis of Ribosomal Transpeptidation, Translocation, and Nascent Peptide Folding

1986 • 16 citations

The Interactions of Elongation Factor Tu

1977 • 16 citations

Changes in form of elongation factor 1 during germination of wheat seeds

1984 • 16 citations

Differences in physical and biological properties of 50S ribosomes and 23S RNAs derived from tight and loose couple 70S ribosomes

1984 • 15 citations

Affinity labeling of eukaryotic elongation factors using N^ε-bromoacetyl-Lys-tRNA

1980 • 15 citations

Protein synthesis in yeast. Identification of an altered elongation factor in thermolabile mutants of the yeast Saccharomyces cerevisiae.

1986 • 15 citations

Structure and location of initiation factor eIF-3 within native small ribosomal subunits from eukaryotes.

1986 • 14 citations

On the role of the termination factor RF‐2 and the 16S RNA in protein synthesis

1989 • 14 citations

The accuracy of protein synthesis in reticulocyte and HeLa cell lysates

1985 • 14 citations

The effect of GTP hydrolysis and transpeptidation on the arrangement of aminoacyl‐tRNA at the A‐site of Escherichia coli 70 S ribosomes

1985 • 13 citations

Characterization and properties of a 5S‐RNA‐protein complex released from heated 60S ribosomal subunits

1984 • 12 citations

Properties and Spatial Arrangement of Components in Preinitiation Complexes of Eukaryotic Protein Synthesis

1985 • 11 citations

Reconstitution of the active rat liver 60 S ribosomal subunit from different preparations of core particles and split proteins

1988 • 11 citations

New aspects of the eukaryotic ribosomal subunit interaction

1979 • 11 citations

Structure and Function of Rat‐Liver Ribosomes

1976 • 11 citations

The yeastSUFSframeshift suppressor encodes a mutant glycine tRNA_ccc

1988 • 11 citations

Phosphorylation of elongation factor 2 in the rat superior cervical ganglion

1988 • 10 citations

Attachment of the 5'-terminal portion of globin mRNAs to 5S-RNA . L5-protein in the 80S initiation complex

1985 • 10 citations

Electron microscopic study of eukaryotic 40S initiation complex in protein synthesis.

1983 • 9 citations

Functional groups of elongation factor 2 involved in interactions with guanosine nucleotides and ribosomes

1983 • 9 citations

A polypeptide chain release factor from the undeveloped cyst of the brine shrimp,Artemia salina

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