Regulation of the development of helper T cell subsets

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.

1988 • 172 citations

CD4+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro.

1990 • 141 citations

The Role of IL4 and IL5: Characterization of a Distinct Helper T Cell Subset that makes IL4 and IL5 (Th2) and Requires Priming before Induction of Lymphokine Secretion

1988 • 123 citations

Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection

1991 • 102 citations

Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells.

1990 • 99 citations