Interferon-α Suppresses the Capacity of T Cells to Help Antibody Production by Human B Cells

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration

1968 • 2,659 citations

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

1988 • 939 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

Leukocyte Interferon-Induced Tumor Regression in Human Metastatic Breast Cancer, Multiple Myeloma, and Malignant Lymphoma

1980 • 503 citations

Synthesis in E. coli of a polypeptide with human leukocyte interferon activity

1980 • 484 citations

Recombinant Leukocyte A Interferon: Pharmacokinetics, Single-Dose Tolerance, and Biologic Effects in Cancer Patients

1982 • 381 citations

Interleukin 4 induces synthesis of IgE and IgG4 in human B cells

1989 • 300 citations

Regulation and deregulation of human IgE synthesis

1990 • 254 citations

Cognate interactions between helper T cells and B cells

1990 • 165 citations

Comparison of the Antiviral Activities of Various Cloned Human Interferon- Subtypes in Mammalian Cell Cultures

1981 • 164 citations

Cellular Interactions in the Humoral Immune Response

1989 • 121 citations

Various human interferon a subclasses cross-react with common receptors: Their binding affinities correlate with their specific biological activities

1984 • 113 citations

Suppression of Mouse Antibody Producing Spleen Cells by Various Interferon Preparations

1973 • 109 citations

Cognate interactions between helper T cells and B cells. III. Contact-dependent, lymphokine-independent induction of B cell cycle entry by activated helper T cells.

1989 • 90 citations

Mutant EL-4 thymoma cells polyclonally activate murine and human B cells via direct cell interaction.

1985 • 88 citations

Biological Activities and Receptor Binding of Two Human Recombinant Interferons and their Hybrids

1986 • 83 citations

Induction of human IgE synthesis by CD4+ T cell clones. Requirement for interleukin 4 and low molecular weight B cell growth factor.

1989 • 80 citations

A Recombinant Human Interferon- B/D Hybrid with a Broad Host-range

1987 • 74 citations

Human peripheral blood B lymphocyte subpopulations: functional and phenotypic analysis of surface IgD positive and negative subsets.

1986 • 73 citations

Expression, renaturation and purification of recombinant human interleukin 4 from Escherichia coli

1988 • 62 citations

Theoretical and Practical Aspects of B‐Cell Activation: Murine and Human Systems

1987 • 58 citations

Frequencies of the separate human B cell subsets activatable to Ig secretion by Epstein-Barr virus and pokeweed mitogen.

1983 • 56 citations

Analysis of the mechanisms of T cell-dependent polyclonal activation of human B cells. Induction of human B cell responses by fixed activated T cells.

1991 • 52 citations

Frequency of human B cells that differentiate in response to anti-CD3 activated T cells

1991 • 36 citations

Modulation of immune responses in newborn and adult mice by interferon

1978 • 30 citations

Release of discrete interferons by cytotoxic T lymphocytes in response to immune and nonimmune stimuli.

1984 • 29 citations

Frequency of human B cells that differentiate in response to anti-CD3-activated T cells.

1990 • 28 citations

Studies on the mechanism of polyclonal B cell stimulation by T_H2 cells

1989 • 24 citations

Enhancement of a human antibody response in vitro mediated by interaction of interferon-alpha with T lymphocytes.

1987 • 18 citations

Immunoregulatory effects of interferon-alpha. I. Interferon-alpha inhibits in vitro antibody synthesis by normal human lymphocytes.

1985 • 11 citations

Production of type I (α/β) interferon after virus infection of cloned, alloantigen‐sensitized mouse T lymphocytes

1984 • 8 citations

Interferon-α and interferon-γ as regulators of human adult and newborn B-cell function

1989 • 3 citations