RNA Silencing in Plants--Defense and Counterdefense

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

RNAi

2000 • 2,596 citations

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans

2001 • 1,779 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

1998 • 1,121 citations

Arabidopsis SGS2 and SGS3 Genes Are Required for Posttranscriptional Gene Silencing and Natural Virus Resistance

2000 • 1,082 citations

Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana

1998 • 1,073 citations

An RNA-Dependent RNA Polymerase Gene in Arabidopsis Is Required for Posttranscriptional Gene Silencing Mediated by a Transgene but Not by a Virus

2000 • 1,061 citations

Suppression of gene silencing: A general strategy used by diverse DNA and RNA viruses of plants

1999 • 1,038 citations

Initiation and Maintenance of Virus-Induced Gene Silencing

1998 • 972 citations

Total silencing by intron-spliced hairpin RNAs

2000 • 968 citations

RNA-directed de novo methylation of genomic sequences in plants

1994 • 929 citations

A viral suppressor of gene silencing in plants

1998 • 897 citations

Transcriptional silencing and promoter methylation triggered by double-stranded RNA

2000 • 866 citations

PKR; a sentinel kinase for cellular stress

1999 • 823 citations

A Similarity Between Viral Defense and Gene Silencing in Plants

1997 • 821 citations

Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions

1997 • 777 citations

mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD

1999 • 745 citations

Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance.

1993 • 734 citations

Reduced DNA methylation in Arabidopsis thaliana results in abnormal plant development.

1996 • 705 citations

Maintenance of genomic methylation requires a SWI2/SNF2-like protein

1999 • 689 citations

A Viral Movement Protein Prevents Spread of the Gene Silencing Signal in Nicotiana benthamiana

2000 • 677 citations

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

1999 • 653 citations

Plant viral synergism: the potyviral genome encodes a broad-range pathogenicity enhancer that transactivates replication of heterologous viruses.

1997 • 589 citations

AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals

2000 • 555 citations

EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans

2000 • 546 citations

Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain

2000 • 426 citations

Double-Stranded RNA as a Template for Gene Silencing

2000 • 421 citations

Plants combat infection by gene silencing

1997 • 384 citations

Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation.

1996 • 373 citations

Disruption of an RNA helicase/RNAse III gene in Arabidopsis causes unregulated cell division in floral meristems

1999 • 368 citations

SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis

2001 • 365 citations

Virus-encoded suppressor of posttranscriptional gene silencing targets a maintenance step in the silencing pathway

2000 • 363 citations

Post-transcriptional gene silencing across kingdoms

2000 • 353 citations

A Calmodulin-Related Protein That Suppresses Posttranscriptional Gene Silencing in Plants

2000 • 351 citations

HC-Pro Suppression of Transgene Silencing Eliminates the Small RNAs but Not Transgene Methylation or the Mobile Signal

2001 • 310 citations

RNA interference: genetic wand and genetic watchdog

2000 • 309 citations

RNA-Mediated RNA Degradation and Chalcone Synthase A Silencing in Petunia

1997 • 308 citations

An important role of an inducible RNA-dependent RNA polymerase in plant antiviral defense

2001 • 307 citations

Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation.

1994 • 284 citations

Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance

1993 • 262 citations

Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase

1999 • 252 citations

Gene silencing in worms and fungi

2000 • 251 citations

DNA methylation and chromatin structure affect transcriptional and post-transcriptional transgene silencing in Arabidopsis

2000 • 238 citations

dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference

2000 • 232 citations

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH₂-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways

2000 • 203 citations

Endogenous Targets of Transcriptional Gene Silencing in Arabidopsis

2000 • 154 citations

High-efficiency silencing of a beta-glucuronidase gene in rice is correlated with repetitive transgene structure but is independent of DNA methylation.

2000 • 152 citations

A Link Between RNA Interference and Nonsense-Mediated Decay in Caenorhabditis elegans

2000 • 145 citations

Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target

2000 • 105 citations

Distinct features of post‐transcriptional gene silencing by antisense transgenes in single copy and inverted T‐DNA repeat loci

2000 • 89 citations

RNA silencing

2000 • 52 citations