The self-destructive personality of a cell cycle in transition

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

Mitosis in transition

1994 • 745 citations

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

1995 • 745 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

1995 • 561 citations

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

1995 • 492 citations

The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases

1989 • 486 citations

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.

1993 • 483 citations

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle

1994 • 478 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

The Yeast Cell Cycle Gene CDC34 Encodes a Ubiquitin-Conjugating Enzyme

1988 • 435 citations

S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase

1993 • 422 citations

A family of cyclin homologs that control the G1 phase in yeast.

1989 • 416 citations

The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation.

1992 • 414 citations

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

1994 • 402 citations

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

1995 • 369 citations

The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1

1989 • 326 citations

Cyclin Ubiquitination: The destructive end of mitosis

1995 • 304 citations

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.

1994 • 301 citations

p34^Cdc28-Mediated Control of Cln3 Cyclin Degradation

1995 • 293 citations

One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis

1990 • 291 citations

Cell cycle checkpoints

1994 • 284 citations

Regulated degradation of the transcription factor Gcn4.

1994 • 271 citations

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.

1993 • 270 citations

Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit

1993 • 244 citations

Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis.

1994 • 243 citations

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

1994 • 235 citations

Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase

1990 • 222 citations

Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.

1995 • 213 citations

Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.

1991 • 196 citations

An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells.

1994 • 164 citations

Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis.

1994 • 151 citations

Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents.

1994 • 148 citations

The genetics of cell cycle checkpoints

1995 • 143 citations

P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae.

1994 • 142 citations

Cell cycle regulation of thymidine kinase: residues near the carboxyl terminus are essential for the specific degradation of the enzyme at mitosis.

1991 • 139 citations

The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition.

1994 • 130 citations

Degradation of Mos by the N-terminal proline (Pro2)-dependent ubiquitin pathway on fertilization of Xenopus eggs: possible significance of natural selection for Pro2 in Mos.

1993 • 127 citations

Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells.

1994 • 126 citations

Pendulin, a Drosophila protein with cell cycle-dependent nuclear localization, is required for normal cell proliferation.

1995 • 124 citations

Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2.

1994 • 111 citations

The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis.

1995 • 108 citations

G₁ Cyclin Degradation: the PEST Motif of Yeast Cln2 Is Necessary, but Not Sufficient, for Rapid Protein Turnover

1994 • 108 citations

Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase.

1994 • 106 citations

Mitotic destruction of the cell cycle regulated NIMA protein kinase of Aspergillus nidulans is required for mitotic exit.

1995 • 100 citations

The Glc7 Type 1 Protein Phosphatase of Saccharomyces cerevisiae Is Required for Cell Cycle Progression in G₂/M

1994 • 98 citations

Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast.

1993 • 90 citations

The yeast Cln3 protein is an unstable activator of Cdc28.

1993 • 90 citations

Make it or break it: the role of ubiquitin-dependent proteolysis in cellular regulation

1995 • 83 citations

G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover.

1994 • 74 citations

The Ubc3 (Cdc34) ubiquitin-conjugating enzyme is ubiquitinated and phosphorylated in vivo.

1994 • 73 citations

FAR1 and the G₁ Phase Specificity of Cell Cycle Arrest by Mating Factor in Saccharomyces cerevisiae

1995 • 61 citations

BIMA, a TPR-containing protein required for mitosis, localizes to the spindle pole body in Aspergillus nidulans.

1993 • 61 citations

The Glc7 type 1 protein phosphatase of Saccharomyces cerevisiae is required for cell cycle progression in G2/M.

1994 • 60 citations

A relationship between the yeast cell cycle genes CDC4 and CDC36 and the ets sequence of oncogenic virus E26

1984 • 51 citations

Cell cycle-regulated degradation of Xenopus cyclin B2 requires binding to p34cdc2.

1994 • 31 citations

Mutations in PRG1, a yeast proteasome-related gene, cause defects in nuclear division and are suppressed by deletion of a mitotic cyclin gene.

1994 • 25 citations

A non-cycling mitotic cyclin in the naturally synchronous cell cycle of Physarum polycephalum.

1994 • 10 citations