Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the α1B-Adrenergic Receptor

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

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1989 • 1,244 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.

1982 • 573 citations

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

1988 • 566 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

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1987 • 478 citations

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1989 • 451 citations

Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites

1982 • 441 citations

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

1994 • 414 citations

Arrestin Interactions with G Protein-coupled Receptors

1995 • 385 citations

Light dependent phosphorylation of rhodopsin by ATP

1972 • 370 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor

1995 • 317 citations

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

1993 • 234 citations

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.

1994 • 218 citations

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

1991 • 214 citations

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.

1994 • 202 citations

The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain

1992 • 197 citations

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.

1991 • 189 citations

A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor.

1994 • 182 citations

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

1993 • 178 citations

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.

1993 • 159 citations

Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.

1987 • 156 citations

Polypeptide variants of beta-arrestin and arrestin3

1993 • 156 citations

Receptor class desensitization of leukocyte chemoattractant receptors.

1991 • 146 citations

Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.

1993 • 139 citations

Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the alpha 1B-adrenergic receptor.

1994 • 132 citations

Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.

1994 • 109 citations

Isolation of Drosophila genes encoding G protein-coupled receptor kinases.

1991 • 100 citations

A novel G protein-coupled receptor kinase gene cloned from 4p16.3

1992 • 99 citations

Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.

1994 • 99 citations

Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase

1993 • 96 citations

Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6.

1994 • 85 citations

Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases.

1995 • 68 citations

Homologous desensitization of thrombin-induced phosphoinositide breakdown in hamster lung fibroblasts.

1988 • 57 citations

Pleckstrin Inhibits Phosphoinositide Hydrolysis Initiated by G-protein-coupled and Growth Factor Receptors. A ROLE FOR PLECKSTRIN'S PH DOMAINS

1995 • 45 citations

Homologous and heterologous desensitization of histamine H₁‐and ATP‐receptors in the smooth muscle cell line, DDT₁MF‐2: the role of protein kinase C

1993 • 35 citations

Homologous desensitization of bombesin‐induced increases in intracellular Ca²⁺ in quiescent swiss 3T3 cells involves a protein kinase C‐independent mechanism

1993 • 27 citations