Clathrin-mediated Endocytosis of the β-Adrenergic Receptor Is Regulated by Phosphorylation/Dephosphorylation of β-Arrestin1

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION

1973 • 2,122 citations

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

1992 • 531 citations

Acid and base hydrolysis of phosphoproteins bound to Immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins

1989 • 469 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

1990 • 393 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

Arrestin Interactions with G Protein-coupled Receptors

1995 • 385 citations

Receptors compete for adaptors found in plasma membrane coated pits.

1988 • 366 citations

The Role of Sequestration in G Protein-coupled Receptor Resensitization

1997 • 356 citations

The role of clathrin, adaptors and dynamin in endocytosis

1994 • 343 citations

Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptor.

1989 • 336 citations

Arrestin Function in Inactivation of G Protein-Coupled Receptor Rhodopsin in Vivo

1993 • 313 citations

Arrestin/Clathrin Interaction

1997 • 290 citations

Interaction of Activated EGF Receptors with Coated Pit Adaptins

1993 • 259 citations

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

1993 • 234 citations

Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor

1996 • 230 citations

Assembly polypeptides from coated vesicles mediate reassembly of unique clathrin coats.

1983 • 228 citations

Arrestin/Clathrin Interaction

1997 • 209 citations

Phosphorylation and Desensitization of Human Endothelin A and B Receptors

1997 • 185 citations

Inactivation of photoexcited rhodopsin in retinal rods: the roles of rhodopsin kinase and 48-kDa protein (arrestin)

1988 • 185 citations

The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.

1995 • 176 citations

In vivo phosphorylation of adaptors regulates their interaction with clathrin.

1996 • 157 citations

The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components.

1993 • 157 citations

Regulation of G Protein-Coupled Receptors by Receptor Kinases and Arrestins

1995 • 128 citations

Protein Tyrosine Kinase Activity and Its Endogenous Substrates in Rat Brain: A Subcellular and Regional Survey

1988 • 108 citations

In vitro binding of the asialoglycoprotein receptor to the beta adaptin of plasma membrane coated vesicles.

1991 • 102 citations

Pathways of internalization of the hCG/LH receptor: immunoelectron microscopic studies in Leydig cells and transfected L-cells.

1992 • 102 citations

Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.

1996 • 95 citations

Clathrin-coated pits contain an integral membrane protein that binds the AP-2 subunit with high affinity.

1990 • 93 citations

Direct Observation of Endocytosis of Gastrin Releasing Peptide and Its Receptor

1995 • 85 citations

Human Muscarinic Cholinergic Receptor Hm1 Internalizes via Clathrin-coated Vesicles

1996 • 80 citations

Dynamin and receptor‐mediated endocytosis

1996 • 74 citations

Recombinant circle PCR and recombination PCR for site-specific mutagenesis without PCR product purification.

1992 • 60 citations

The α Chain of the AP-2 Adaptor Is a Clathrin Binding Subunit

1995 • 52 citations

Binding of Purified Recombinant beta-arrestin to Guanine-Nucleotide-Binding-Protein-Coupled Receptors

1995 • 42 citations

Binding of Purified Recombinant beta-arrestin to Guanine-Nucleotide-Binding-Protein-Coupled Receptors

1995 • 39 citations

[20] Measurement of stoichiometry of protein phosphorylation by biosynthetic labeling

1991 • 23 citations