Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation.

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay

1973 • 3,279 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

The Human Hematopoietic Colony-Stimulating Factors

1987 • 1,728 citations

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1989 • 1,097 citations

Granulocyte colony-stimulating factor and its receptor

1991 • 975 citations

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

1985 • 718 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

1991 • 597 citations

Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.

1983 • 559 citations

A novel family of growth factor receptors: A common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor β-chain

1989 • 551 citations

A new cytokine receptor superfamily

1990 • 506 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

Control of Granulocytes and Macrophages: Molecular, Cellular, and Clinical Aspects

1991 • 377 citations

A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization

1989 • 370 citations

Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line.

1987 • 369 citations

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.

1992 • 365 citations

Expression cloning of a receptor for murine granulocyte colony-stimulating factor

1990 • 362 citations

Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)

1987 • 357 citations

Functional domains of the granulocyte colony-stimulating factor receptor.

1991 • 342 citations

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

1990 • 325 citations

Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.

1990 • 304 citations

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

1991 • 297 citations

Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo.

1992 • 284 citations

Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.

1991 • 231 citations

Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains.

1990 • 213 citations

Purification and characterization of the receptor for murine granulocyte colony-stimulating factor.

1990 • 180 citations

Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.

1993 • 174 citations

A Truncated Erythropoietin Receptor That Fails to Prevent Programmed Cell Death of Erythroid Cells

1992 • 156 citations

Distinct Regions of the Human Granulocyte-Colony-Stimulating Factor Receptor Cytoplasmic Domain Are Required for Proliferation and Gene Induction

1993 • 138 citations

Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.

1988 • 130 citations

In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130.

1992 • 127 citations

Deregulated c-myb disrupts interleukin-6- or leukemia inhibitory factor-induced myeloid differentiation prior to c-myc: role in leukemogenesis.

1992 • 115 citations

Interleukin-6- and leukemia inhibitory factor-induced terminal differentiation of myeloid leukemia cells is blocked at an intermediate stage by constitutive c-myc.

1991 • 99 citations

Granulocyte colony-stimulating factor receptors in human acute myelocytic leukemia

1989 • 99 citations

Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor.

1991 • 97 citations

Oncostatin M is a differentiation factor for myeloid leukemia cells.

1992 • 94 citations

Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation

1991 • 87 citations

Granulocyte colony‐stimulating factor and differentiation‐induction in myeloid leukemic cells

1987 • 86 citations

Binding of G-CSF, GM-CSF, tumor necrosis factor-alpha, and gamma- interferon to cell surface receptors on human myeloid leukemia cells triggers rapid tyrosine and serine phosphorylation of a 75-Kd protein

1990 • 69 citations

Effect of interleukin 6 (IL-6) on the differentiation and proliferation of murine and human hemopoietic progenitors.

1988 • 64 citations

Human AML colony growth in serum-free culture

1988 • 52 citations

Characterization of receptor for granulocyte colony-stimulating factor on human circulating neutrophils

1988 • 51 citations

Different stromal cell lines support lineage-selective differentiation of the multipotential bone marrow stem cell clone LyD9.

1991 • 37 citations

Interleukin 3, granulocyte-macrophage colony-stimulating factor, and transfected erythropoietin receptors mediate tyrosine phosphorylation of a common cytosolic protein (pp100) in FDC-ER cells.

1992 • 32 citations

Alternative forms of the human G-CSF receptor function in growth signal transduction.

1991 • 17 citations