Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1994 • 1,081 citations

Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

1990 • 1,012 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization

1994 • 921 citations

c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

1994 • 689 citations

Thrombocytopenia in c-mpl-deficient mice

1994 • 680 citations

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

1992 • 525 citations

A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors

1990 • 404 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 359 citations

Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

1988 • 296 citations

Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells.

1991 • 284 citations

In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells

1994 • 268 citations

Complete replacement of serum in primary cultures of erythropoietin-dependent red cell precursors (CFU-E) by albumin, transferrin, iron, unsaturated fatty acid, lecithin and cholesterol

1980 • 253 citations

Purification and Characterization of Thrombopoietin1

1995 • 251 citations

Molecular cloning and chromosomal localization of the human thrombopoietin gene

1994 • 237 citations

Blast cell colony assay for umbilical cord blood and adult bone marrow progenitors

1987 • 152 citations

Human recombinant granulocyte-macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities.

1988 • 149 citations

Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.

1994 • 147 citations

M‐07e human leukemic factor‐dependent cell line provides a rapid and sensitive bioassay for the human cytokines GM‐CSF and IL‐3

1990 • 144 citations

Human burst-forming units-erythroid need direct interaction with stem cell factor for further development

1991 • 138 citations

Effects of recombinant human erythropoietin on megakaryocytes and on platelet production in the rat

1988 • 138 citations

Human P40 T-cell growth factor (interleukin-9) supports erythroid colony formation

1990 • 114 citations

Demonstration of burst-promoting activity of recombinant human GM-CSF on circulating erythroid progenitors using an assay involving the delayed addition of erythropoietin

1985 • 112 citations

The structure, biology and potential therapeutic applications of recombinant thrombopoietin

1994 • 77 citations

Erythroid burst-promoting activity of purified recombinant human GM-CSF and interleukin-3: studies with anti-GM-CSF and anti-IL-3 sera and studies in serum-free cultures

1988 • 64 citations

Effect of interleukin-9 on clonogenic maturation and cell-cycle status of fetal and adult hematopoietic progenitors

1991 • 63 citations

c-kit ligand reactivates fetal hemoglobin synthesis in serum-free culture of stringently purified normal adult burst-forming unit- erythroid

1993 • 56 citations

Human marrow erythropoiesis in culture: II. Heterogeneity in the morphology, time course of colony formation, and sedimentation velocities of the colony‐forming cells

1977 • 56 citations

Evidence for direct action of human biosynthetic (recombinant) GM-CSF on erythroid progenitors in serum-free culture

1987 • 52 citations

Enhancement of the growth of human early erythroid progenitors by bone marrow conditioned media.

1980 • 35 citations

Induction of mixed erythroid-megakaryocyte colonies and bipotential blast cell colonies by recombinant human erythropoietin in serum-free culture

1990 • 34 citations

Serum‐free culture of human hemopoietic progenitors in attenuated culture media

1988 • 20 citations