Current Concepts in the Pathogenesis of Age-Related Macular Degeneration

A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss

2001 • 3,104 citations

Mitochondrial Diseases in Man and Mouse

1999 • 3,008 citations

The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration

2000 • 1,987 citations

Prevalence of Age-related Maculopathy

1992 • 1,864 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis

1999 • 1,494 citations

Free-radical chemistry of cigarette smoke and its toxicological implications.

1985 • 1,351 citations

An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration

2001 • 1,256 citations

Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group

1994 • 1,170 citations

Drusen proteome analysis: An approach to the etiology of age-related macular degeneration

2002 • 1,161 citations

The Five-year Incidence and Progression of Age-related Maculopathy

1997 • 1,144 citations

A role for local inflammation in the formation of drusen in the aging eye

2002 • 1,068 citations

Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

2000 • 915 citations

Ageing and degeneration in the macular region: a clinico-pathological study.

1976 • 868 citations

Mutation of the Stargardt Disease Gene ( ABCR ) in Age-Related Macular Degeneration

1997 • 861 citations

The Prevalence of Age-related Maculopathy in the Rotterdam Study

1995 • 825 citations

Evolution of geographic atrophy of the retinal pigment epithelium

1988 • 762 citations

Age-related Macular Degeneration Histopathologic Studies

1993 • 747 citations

Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging.

1994 • 707 citations

The biology of the receptor for advanced glycation end products and its ligands

2000 • 690 citations

Tie2 Receptor Ligands, Angiopoietin-1 and Angiopoietin-2, Modulate VEGF-Induced Postnatal Neovascularization

1998 • 680 citations

Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy

1994 • 660 citations

Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor

1996 • 622 citations

An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

2003 • 620 citations

Oxidative damage and protection of the RPE

2000 • 616 citations

Histology of the Human Eye: An Atlas and Textbook

1972 • 602 citations

Complement Activation and Inflammatory Processes in Drusen Formation and Age Related Macular Degeneration

2001 • 598 citations

Drusen and Disciform Macular Detachment and Degeneration

1973 • 593 citations

The Five-year Incidence and Progression of Age-related Maculopathy

1997 • 592 citations

Transdifferentiated Retinal Pigment Epithelial Cells are Immunoreactive for Vascular Endothelial Growth Factor in Surgically Excised AgeRelated Macular Degeneration-Related Choroidal Neovascular Membranes.

1998 • 590 citations

Prevention of Experimental Choroidal Neovascularization With Intravitreal Anti–Vascular Endothelial Growth Factor Antibody Fragment

2002 • 589 citations

Oxidative Damage and Age Related Macular Degeneration

2008 • 566 citations

Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells.

1984 • 556 citations

Action des acides amines sur les sucres : formation des melanoidines par voie methodique

1912 • 555 citations

Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes.

1986 • 547 citations

Increased expression of angiogenic growth factors in age-related maculopathy

1997 • 497 citations

Protection of mouse photoreceptors by survival factors in retinal degenerations.

1998 • 496 citations

Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells

1999 • 490 citations

Glutathione in Human Plasma: Decline in Association with Aging, Age-Related Macular Degeneration, and Diabetes

1998 • 487 citations

A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy

1999 • 472 citations

Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells

1998 • 469 citations

The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration

2002 • 436 citations

Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration.

2002 • 424 citations

Advanced glycation end products increase retinal vascular endothelial growth factor expression.

1998 • 413 citations

Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population.

2001 • 407 citations

Aging changes in Bruch's membrane. A histochemical and morphologic study.

1990 • 404 citations

The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes.

1999 • 393 citations

Overexpression of Vascular Endothelial Growth Factor (VEGF) in the Retinal Pigment Epithelium Leads to the Development of Choroidal Neovascularization

2000 • 380 citations

Macular pigment in donor eyes with and without AMD: a case-control study.

2001 • 365 citations

Basal Linear Deposit and Large Drusen Are Specific for Early Age-Related Maculopathy

1999 • 363 citations

Lipofuscin of the retinal pigment epithelium: A review

1995 • 353 citations

A Potential Role for Immune Complex Pathogenesis in Drusen Formation

2000 • 349 citations

Drusen in Age-Related Macular Degeneration

1999 • 330 citations

SENILE MACULAR DEGENERATION: A HISTOPATHOLOGIC STUDY*

2005 • 320 citations

Foveolar choroidal blood flow in age-related macular degeneration.

1998 • 317 citations

Familial Aggregation of Age-related Maculopathy

1998 • 303 citations

Racial Differences in the Prevalence of Age-Related Macular Degeneration

2008 • 298 citations

Senile macular degeneration: The involvement of immunocompetent cells

1985 • 295 citations

THE CELLULAR AND MOLECULAR MECHANISMS OF DIABETIC COMPLICATIONS

1996 • 292 citations

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

1998 • 292 citations

Macrophages related to Bruch's membrane in age-related macular degeneration

1990 • 290 citations

Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin.

2000 • 289 citations

Age-related variation in the hydraulic conductivity of Bruch's membrane.

1995 • 283 citations

Epidemiology of Age-Related Macular Degeneration

2005 • 278 citations

Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin.

1999 • 276 citations

The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium

2002 • 274 citations

The Relationship of Cardiovascular Disease and Its Risk Factors to Age-related Maculopathy

1993 • 269 citations

Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells.

1989 • 266 citations

Apolipoprotein B in Cholesterol-Containing Drusen and Basal Deposits of Human Eyes with Age-Related Maculopathy

2003 • 261 citations

Novel mechanism for age‐related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF

2001 • 258 citations

Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopathological study

1999 • 258 citations

High-resolution histologic analysis of the human choroidal vasculature.

1994 • 255 citations

Analysis of Lipid Deposits Extracted From Human Macular and Peripheral Bruch's Membrane

1994 • 254 citations

Evolution of soft drusen in age-related macular degeneration

1994 • 251 citations

Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation

2001 • 243 citations

Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes.

1999 • 238 citations

Associations between Antioxidant and Zinc Intake and the 5-Year Incidence of Early Age-related Maculopathy in the Beaver Dam Eye Study

1998 • 234 citations

Inhibition of Angiogenesis and Murine Hemangioma Growth by Batimastat, a Synthetic Inhibitor of Matrix Metalloproteinases

1995 • 234 citations

Increase in the advanced glycation end product pentosidine in Bruch's membrane with age.

1999 • 233 citations

Intrachoroidal Neovascularization in Transgenic Mice Overexpressing Vascular Endothelial Growth Factor in the Retinal Pigment Epithelium

2001 • 229 citations

CLINICOPATHOLOGIC CORRELATION OF DRUSEN AND RETINAL PIGMENT EPITHELIAL ABNORMALITIES IN AGE-RELATED MACULAR DEGENERATION

2005 • 229 citations

Genetic influence on early age-related maculopathy

2002 • 229 citations

Mitochondrial DNA in Aging and Disease

1997 • 227 citations

AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization.

2002 • 226 citations

Retinal Pigment Epithelial Cell Count, Distribution, and Correlations in Normal Human Eyes

1996 • 223 citations

Oxygen distribution in the macaque retina.

1993 • 221 citations

Changes in choriocapillaris and retinal pigment epithelium in age-related macular degeneration.

1999 • 218 citations

Lipofuscin is a photoinducible free radical generator

1993 • 217 citations

Night blindness in Sorsby's fundus dystrophy reversed by vitamin A

1995 • 213 citations

Ocular Age Pigment “A2-E”: An Unprecedented Pyridinium Bisretinoid

1996 • 210 citations

The Macular Pigment: A Possible Role in Protection from Age-Related Macular Degeneration

1996 • 210 citations

Age-Related Changes in the Ultrastructure of Bruch's Membrane

1985 • 208 citations

Cigarette Smoking and Retinal Carotenoids: Implications for Age-related Macular Degeneration

1996 • 207 citations

Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells

1999 • 206 citations

Lower levels of vitamin C and carotenes in plasma of cigarette smokers.

1986 • 204 citations

Choroidal Perfusion Abnormality With Age-Related Bruch's Membrane Change

1990 • 200 citations

Histology of the Human Eye: An Atlas and Textbook

1972 • 199 citations

Is the incidence of registrable age-related macular degeneration increasing?

1996 • 198 citations

Effects of Intravitreal Administration of Steroids on Experimental Subretinal Neovascularization in the Subhuman Primate

1985 • 197 citations

The prevalence of age-related maculopathy by geographic region and ethnicity1This paper has been edited by Neville N. Osborne, PhD, DSc, Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford, UK; and Gerald J. Chader, The Foundation Fighting Blindness, Hunt Valley, MS.1

1999 • 196 citations

Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.

1991 • 196 citations

Autofluorescence distribution associated with drusen in age-related macular degeneration.

2000 • 194 citations

Sex Differences in Macular Pigment Optical Density:

1996 • 193 citations

CLINICOPATHOLOGIC CORRELATION OF DRUSEN AND RETINAL PIGMENT EPITHELIAL ABNORMALITIES IN AGE-RELATED MACULAR DEGENERATION

1994 • 191 citations

Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor.

2002 • 189 citations

Quantifying changes in RPE and choroidal vasculature in eyes with age-related macular degeneration.

2002 • 187 citations

Fundus autofluorescence in patients with age-related macular degeneration and high risk of visual loss11Commercial interests: None.

2002 • 182 citations

Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization.

2000 • 180 citations

Matrix metalloproteinases and metalloproteinase inhibitors in choroidal neovascular membranes.

1998 • 179 citations

Immunobiology and privilege of neuronal retina and pigment epithelium transplants

2002 • 179 citations

TIMP-3 in Bruch's membrane: changes during aging and in age-related macular degeneration.

1999 • 178 citations

Antioxidant Enzymes in the Aging Human Retinal Pigment Epithelium

1991 • 177 citations

Advanced Glycation End Products in Age-related Macular Degeneration

1998 • 177 citations

Hydrodynamics of Ageing Bruch's Membrane: Implications for Macular Disease

1996 • 172 citations

Dramatic Inhibition of Retinal and Choroidal Neovascularization by Oral Administration of a Kinase Inhibitor

1999 • 171 citations

The Photoreactivity of the Retinal Age Pigment Lipofuscin

1999 • 169 citations

Triamcinolone acetonide modulates permeability and intercellular adhesion molecule-1 (ICAM-1) expression of the ECV304 cell line: implications for macular degeneration

2000 • 169 citations

Effect of Aging on Foveolar Choroidal Circulation

1998 • 169 citations

Fas ligand (CD95 ligand) controls angiogenesis beneath the retina

1999 • 168 citations

The natural history of geographic atrophy, the advanced atrophic form of age-related macular degeneration.

1999 • 168 citations

Role of hypoxia and extracellular matrix‐integrin binding in the modulation of angiogenic growth factors secretion by retinal pigmented epithelial cells

1999 • 167 citations

Functional loss in age-related Bruch's membrane change with choroidal perfusion defect.

1992 • 165 citations

Granulomatous Reaction to Bruch's Membrane in Age-Related Macular Degeneration

1994 • 164 citations

The relationships of age changes in retinal pigment epithelium and Bruch's membrane.

1999 • 164 citations

Senile Choroidal Vascular Patterns and Drusen

1963 • 162 citations

Basal linear deposit in the human macula

1986 • 159 citations

Changes in Bruch’s membrane and related structures with age

1999 • 159 citations

Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisation.

1996 • 158 citations

Age-related macular degeneration is associated with increased vascular endothelial growth factor, hemorheology and endothelial dysfunction

2001 • 157 citations

Age-related Macular Degeneration and Antioxidant Status in the POLA Study

1999 • 154 citations

Atrophic Macular Degeneration

1989 • 154 citations

Spectral profiling of autofluorescence associated with lipofuscin, Bruch's Membrane, and sub-RPE deposits in normal and AMD eyes.

2002 • 152 citations

Circulating Matrix Metalloproteinases and Their Inhibitors in Premature Coronary Atherosclerosis

2001 • 151 citations

Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.

1997 • 146 citations

The development of choroidal neovascularization in eyes with the geographic atrophy form of age-related macular degeneration11The authors have no proprietary interest in any aspect of this study.

1999 • 143 citations

Color Doppler imaging discloses reduced ocular blood flow velocities in nonexudative age-related macular degeneration

1999 • 142 citations

Epidemiology of Age-related Maculopathy

1995 • 141 citations

Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD).

2001 • 139 citations

The effect of age on the macromolecular permeability of human Bruch's membrane.

2001 • 139 citations

Preparation of Bruch's membrane and analysis of the age-related changes in the structural collagens.

1995 • 134 citations

Iris Color and Macular Pigment Optical Density

1996 • 134 citations

Morphology of early choroidal neovascularisation in age-related macular degeneration: Correlation with activity

1997 • 133 citations

Correlation between Lipids Extracted from Bruch's Membrane and Age

1993 • 132 citations

Macular pigment and melanin in age-related maculopathy in a general population.

2002 • 131 citations

The Prevalence of Age-Related Maculopathy by Geographic Region and Ethnicity

1997 • 131 citations

Localization of the Functional Domains of Human Tissue Inhibitor of Metalloproteinases-3 and the Effects of a Sorsby's Fundus Dystrophy Mutation

1998 • 128 citations

CHARACTERIZATION OF PEROXIDIZED LIPIDS IN BRUCHʼS MEMBRANE

1999 • 127 citations

The pathogenesis of choroidal neovascularization in patients with age-related macular degeneration.

1999 • 126 citations

Early stages of age-related macular degeneration: an immunofluorescence and electron microscopy study.

1993 • 126 citations

Autoantibodies to retinal astrocytes associated with age-related macular degeneration

1990 • 125 citations

The lipid composition of drusen, Bruch's membrane, and sclera by hot stage polarizing light microscopy.

2001 • 122 citations

Growth Factors in Age-Related Macular Degeneration: Pathogenic and Therapeutic Implications

1997 • 122 citations

Effect of Elastin Peptides on Vascular Tone

1995 • 121 citations

Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes.

1999 • 121 citations

Mitochondrial biology, degenerative diseases and aging

1998 • 118 citations

Zinc in the eye

1982 • 118 citations

A Fluorescein and Indocyanine Green Angiographic Study of Choriocapillaris in Age-related Macular Disease

1999 • 117 citations

Localization of the site of major resistance to fluid transport in Bruch's membrane.

1997 • 116 citations

Formation of Drusen in the Human Eye

1986 • 116 citations

Age-dependent variation in metalloproteinase activity of isolated human Bruch's membrane and choroid.

1999 • 116 citations

Expression of matrix metalloproteinases and inhibitor by human retinal pigment epithelium.

1990 • 116 citations

Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration11This article is derived from a thesis accepted by the American Ophthalmological Society: Frank RN. Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration. Trans Am Ophthalmol Soc 1998;96:635–689.

1999 • 115 citations

The Architecture of the Choriocapillaris at the Posterior Pole

1976 • 114 citations

Dietary antioxidants and age-related maculopathy The blue mountains eye study

1999 • 114 citations

Studies on the Human Macula

1967 • 113 citations

The Histochemistry of Drusen

1971 • 112 citations

AN ULTRASTRUCTURAL STUDY OF THE ROLE OF LEUCOCYTES AND FIBROBLASTS IN THE BREAKDOWN OF BRUCH'S MEMBRANE

1984 • 112 citations

Ageing changes in Bruch's membrane and their functional implications.

1978 • 111 citations

Age-related macular degeneration: ultrastructural studies of the relationship of leucocytes to angiogenesis

1987 • 110 citations

Subfoveal Choroidal Neovascular Membranes in Age-Related Macular Degeneration

1986 • 110 citations

N(epsilon)(carboxymethyl)lysin and the AGE receptor RAGE colocalize in age-related macular degeneration.

1999 • 106 citations

Intravitreal triamcinolone in subfoveal recurrence of choroidal neovascularisation after laser treatment in macular degeneration

2002 • 106 citations

Is Basal Laminar Deposit Unique for Age-Related Macular Degeneration?

1991 • 106 citations

Bruch's membrane age-related changes vary by region

1987 • 103 citations

Effect of aging on aqueous-phase antioxidants in tissues of male Fischer rats

1988 • 103 citations

Central Sparing in Annular Macular Degeneration

1988 • 102 citations

Sub-retinal pigment epithelial deposits in a dominant late-onset retinal degeneration.

1996 • 102 citations

Modulation and function of intercellular adhesion molecule-1 (CD54) on human retinal pigment epithelial cells.

1992 • 101 citations

Exclusion of TIMP3 as a candidate locus in age-related macular degeneration.

1997 • 100 citations

Choroidal Neovascularization Can Digest Bruch's Membrane

1984 • 100 citations

Immunohistochemical characterization of surgically removed subfoveal fibrovascular membranes

1994 • 99 citations

Density of the Human Crystalline Lens is Related to the Macular Pigment Carotenoids, Lutein and Zeaxanthin

1997 • 99 citations

Ultrastructural Localization of Extracellular Matrix Components in Human Retinal Vessels and Bruch's Membrane

1990 • 98 citations

Antiretinal Antibodies in Serum of Patients with Age-related Macular Degeneration

1991 • 98 citations

Effect of elastin peptides on human monocytes: Ca2+ mobilization, stimulation of respiratory burst and enzyme secretion

1986 • 96 citations

Lipofuscin accumulation in cultured retinal pigment epithelial cells reduces their phagocytic capacity

1998 • 96 citations

Retinal pigment epithelial cell transplantation after subfoveal membranectomy in age-related macular degeneration

2001 • 95 citations

Genetic susceptibility to age related macular degeneration

2000 • 93 citations

Pathogenetic Factors of Aging Macular Degeneration

1985 • 92 citations

Associations of antioxidant enzymes with cataract and age-related macular degeneration

1999 • 92 citations

Choroidal perfusion perturbations in non-neovascular age related macular degeneration

2002 • 89 citations

Lipofuscin-formation in retinal pigment epithelial cells is reduced by antioxidants

2001 • 89 citations

Region and age-dependent variation in susceptibility of the human retina to lipid peroxidation.

1992 • 88 citations

Analysis of newly synthesized Bruch's membrane proteoglycans.

1989 • 87 citations

Age-related components of Bruch's membrane in the human eye

1987 • 85 citations

DRUSEN PATTERNS PREDISPOSING TO GEOGRAPHIC ATROPHY OF THE RETINAL PIGMENT EPITHELIUM

1982 • 85 citations

Decreased choriocapillaris perfusion following surgical excision of choroidal neovascular membranes in age-related macular degeneration

1997 • 85 citations

Foveal electroretinograms and choroidal perfusion characteristics in fellow eyes of patients with unilateral neovascular age-related macular degeneration.

1995 • 84 citations

Modulation of major histocompatibility complex class II expression in retinas with age-related macular degeneration.

1997 • 81 citations

Molecular genetics of age-related macular degeneration

2001 • 81 citations

Development of a polyclonal antibody with broad epitope specificity for advanced glycation endproducts and localization of these epitopes in Bruch's membrane of the aging eye.

1999 • 80 citations

Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells.

1999 • 80 citations

Mutation of the Stargardt Disease Gene (ABCR) in Age-related Macular Degeneration

1998 • 79 citations

Antioxidant Action of Carotenoids in Vitro and in Vivo and Protection against Oxidation of Human Low‐Density Lipoproteinsa,b

1993 • 78 citations

Age-related alterations in the diffusional transport of amino acids across the human Bruch’s-choroid complex

2002 • 76 citations

Effect of dietary inducer dimethylfumarate on glutathione in cultured human retinal pigment epithelial cells.

1999 • 75 citations

Epithelium-Capillary Interactions in the Eye: The Retinal Pigment Epithelium and the Choriocapillaris

1989 • 74 citations

Immunodeficiency associated with DNA repair defects

2000 • 74 citations

Systemically Expressed Soluble Tie2 Inhibits Intraocular Neovascularization

2001 • 73 citations

Low glutathione reductase and peroxidase activity in age-related macular degeneration.

1994 • 71 citations

Metallothionein shows an age-related decrease in human macular retinal pigment epithelium.

1993 • 69 citations

Inhibition of experimental choroidal neovascularization by overexpression of tissue inhibitor of metalloproteinases-3 in retinal pigment epithelium cells

2000 • 69 citations

Hematogenous photosensitization. A mechanism for the development of age-related macular degeneration.

1990 • 68 citations

Characterization of Drusen-associated Glycoconjugates

1997 • 68 citations

Matrix metalloproteinase (MMP) expression in experimental choroidal neovascularization

2000 • 66 citations

Expression of metalloproteinases from human retinal pigment epithelial cells and their effects on the hydraulic conductivity of Bruch's membrane.

2002 • 64 citations

Full characterization of the maculopathy associated with an Arg-172-Trp mutation in the RDS/peripherin gene

1996 • 63 citations

Aging of connective tissue

1980 • 62 citations

Lipid peroxidation and antioxidant enzymatic systems in rat retina as a function of age

1992 • 62 citations

Lipofuscin-formation in cultured retinal pigment epithelial cells is related to their melanin content

2001 • 61 citations

Drusen are Cold Spots for Proteolysis: Expression of Matrix Metalloproteinases and Their Tissue Inhibitor Proteins in Age-related Macular Degeneration

2002 • 61 citations

TIMP-3 Is Expressed in the Human Retinal Pigment Epithelium

1996 • 59 citations

Mechanisms of Aging of the Extracellular Matrix: Role of the Elastin-Laminin Receptor

1998 • 59 citations

Vitamin E in macular and peripheral tissues of the human eye

1995 • 59 citations

The Aging of Connective Tissue

1964 • 58 citations

Evaluation of the gene encoding the tissue inhibitor of metalloproteinases-3 in various maculopathies.

1997 • 57 citations

Angiopoietin-1 upregulation by vascular endothelial growth factor in human retinal pigment epithelial cells.

2001 • 57 citations

Interaction of fibronectin with collagen: age-specific defect in the biological activity of human fibroblast fibronectin.

1983 • 54 citations

Decreasing hydraulic conductivity of Bruch's membrane: Relevance to photoreceptor survival and lipofuscinoses

1995 • 52 citations

Pulsatile ocular blood flow in asymmetric exudative age related macular degeneration

2001 • 50 citations

Diverse Gene Sequences Are Overexpressed in Werner Syndrome Fibroblasts Undergoing Premature Replicative Senescence

1991 • 46 citations

Exocytic clearing of degraded membrane material from pigment epithelial cells in frog retina.

1987 • 45 citations

Inhibition of Tumor Angiogenesis^a

1994 • 45 citations

Vitamin E status in a normal population: the influence of age.

1987 • 44 citations

Altered Regulation of Fibronectin Gene Expression in Werner Syndrome Fibroblasts

1994 • 43 citations

Adhesion molecules are expressed in the human retina and choroid

1992 • 41 citations

Iron-induced fluorescence in the retina: dependence on vitamin A.

1994 • 40 citations

Induction of an aging mRNA retinal pigment epithelial cell phenotype by matrix-containing advanced glycation end products in vitro.

2001 • 38 citations

Region-and Age-dependent Variation in Susceptibility of the Human Retina to Lipid Peroxidation

1993 • 38 citations

A Model of the Incidence and Consequences of Choroidal Neovascularization Secondary to Age-related Macular Degeneration

1998 • 37 citations

Gene expression profiling of human diseases by serial analysis of gene expression

2002 • 37 citations

Altered Expression and Regulation of the α5β1 Integrin–Fibronectin Receptor Lead to Reduced Amounts of Functional α5β1 Heterodimer on the Plasma Membrane of Senescent Human Diploid Fibroblasts

1996 • 36 citations

Central sparing in annular macular degeneration

1988 • 32 citations

Selenium and antioxidant vitamin and lipidoperoxidation levels in preaging French population

1997 • 32 citations

[Biochemical and histochemical analysis of age related lipid deposits in Bruch's membrane].

1994 • 32 citations

Gene Expression Profiling of Human Diseases by Serial Analysis of Gene Expression

2002 • 28 citations

Studies of Bruch's Membrane

1957 • 26 citations

Epidemiology of Age-Related Macular Degeneration

2006 • 26 citations

Limited Macular Translocation for Atrophic Maculopathy

2002 • 24 citations

Chronic daily low dose of 4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (Oltipraz) in patients with previously resected colon polyps and first degree female relatives of breast cancer patients.

2000 • 22 citations

Measurement of TIMP-3 Expression and Bruch's Membrane Thickness in Human Macula

2001 • 21 citations

Genetic influence on early age-related maculopathy - A twin study

2002 • 14 citations

Antioxidant Status and Neovascular Age-related Macular Degeneration

1993 • 14 citations

DNA Repair and Transcription in Human Premature Aging Disorders

1998 • 14 citations

Are Antioxidants or Supplements Protective for Age-Related Macular Degeneration?

1994 • 14 citations

Exclusion of TIMP3 as a Candidate Locus in Age-related Macular Degeneration

1998 • 13 citations

Effects of centrophenoxine on lipofuscin in the retinal pigment epithelium of old mice

1983 • 12 citations

DNA Repair and Transcription in Human Premature Aging Disorders

1998 • 11 citations

Lipofuscin accumulation in cultured retinal pigment epithelial cells reduces their phagocytic capacity

1998 • 9 citations

Aging and matrix biology.

1998 • 7 citations

PULSATILE OCULAR BLOOD FLOW IN ASYMMETRIC EXUDATIVE AGE-RELATED MACULAR DEGENERATION

2002 • 3 citations

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