Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes.

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration.

1990 • 857 citations

Increased Vascularization in Mice Overexpressing Angiopoietin-1

1998 • 818 citations

Tie2 Receptor Ligands, Angiopoietin-1 and Angiopoietin-2, Modulate VEGF-Induced Postnatal Neovascularization

1998 • 680 citations

Synergistic Effect of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor on Angiogenesis In Vivo

1995 • 605 citations

Pathogenesis of Disciform Detachment of the Neuroepithelium

1967 • 583 citations

Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis

1998 • 491 citations

Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells

1999 • 490 citations

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

1993 • 470 citations

Angiopoietin-1 induces sprouting angiogenesis in vitro

1998 • 467 citations

Chemotactic Properties of Angiopoietin-1 and -2, Ligands for the Endothelial-specific Receptor Tyrosine Kinase Tie2

1998 • 434 citations

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

1992 • 410 citations

Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

1997 • 410 citations

Reciprocal relation between VEGF and NO in the regulation of endothelial integrity

1997 • 367 citations

Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Are Present in Epiretinal and Choroidal Neovascular Membranes

1996 • 358 citations

Mechanisms of retinal and choroidal neovascularization.

1994 • 288 citations

Growth factor localization in choroidal neovascular membranes of age-related macular degeneration.

1994 • 286 citations

Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage

1993 • 275 citations

Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth.

1997 • 257 citations

Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells

1993 • 224 citations

The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors.

1993 • 179 citations

Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis

1998 • 157 citations

Vasculotropin/Vascular endothelial growth factor is an autocrine growth factor for human retinal pigment epithelial cells cultued in vitro

1995 • 146 citations

Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization

1992 • 132 citations

Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family.

1993 • 129 citations

Histopathologic and Ultrastructural Findings of Surgically Excised Choroidal Neovascularization

1998 • 129 citations

Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas.

1994 • 112 citations

Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.

1993 • 107 citations

Distribution of Growth Factors in Subfoveal Neovascular Membranes in Age-related Macular Degeneration and Presumed Ocular Histoplasmosis Syndrome

1995 • 104 citations

Choroidal Neovascularization Can Digest Bruch's Membrane

1984 • 100 citations

Ulrastructural Immunocytochemistry of Subretinal Neovascular Membranes in Age-related Macular Degeneration

1992 • 66 citations

Mitogenesis and retinal pigment epithelial cell antigen expression in the rat after krypton laser photocoagulation.

1993 • 59 citations

Extracellular modulating factors and the control of intraocular neovascularization: An overview

1990 • 15 citations