Reversal of Tumor-Mediated Immunosuppression

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

2006 • 1,366 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

2004 • 1,136 citations

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

2003 • 1,132 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Gemcitabine Selectively Eliminates Splenic Gr-1+/CD11b+ Myeloid Suppressor Cells in Tumor-Bearing Animals and Enhances Antitumor Immune Activity

2005 • 1,010 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 933 citations

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

2005 • 889 citations

Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

2005 • 878 citations

Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.

2001 • 860 citations

Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species

2004 • 825 citations

Arginase-Producing Myeloid Suppressor Cells in Renal Cell Carcinoma Patients: A Mechanism of Tumor Evasion

2005 • 811 citations

Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation

2002 • 713 citations

Cancer vaccines: between the idea and the reality

2003 • 616 citations

L-arginine metabolism in myeloid cells controls T-lymphocyte functions

2003 • 580 citations

Increased Regulatory T-Cell Fraction Amidst a Diminished CD4 Compartment Explains Cellular Immune Defects in Patients with Malignant Glioma

2006 • 570 citations

Control of T‐cell activation by CD4⁺ CD25⁺ suppressor T cells

2001 • 560 citations

Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance

2003 • 539 citations

Certified Professionals

2001 • 533 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

2005 • 462 citations

Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice.

2001 • 454 citations

STAT1 Signaling Regulates Tumor-Associated Macrophage-Mediated T Cell Deletion

2005 • 431 citations

Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.

2000 • 421 citations

The Makings of a Tumor Rejection Antigen

1999 • 389 citations

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

2005 • 378 citations

Distinct roles of CTLA‐4 and TGF‐β in CD4⁺CD25⁺ regulatory T cell function

2004 • 377 citations

CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma

1998 • 375 citations

Gr-1+ Myeloid Cells Derived from Tumor-Bearing Mice Inhibit Primary T Cell Activation Induced Through CD3/CD28 Costimulation

2000 • 361 citations

Characterization of CD4⁺CD25⁺ Regulatory T Cells in Patients Treated With High-Dose Interleukin-2 for Metastatic Melanoma or Renal Cell Carcinoma

2006 • 348 citations

Derangement of immune responses by myeloid suppressor cells

2003 • 347 citations

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses

1996 • 341 citations

Analysis of the Cellular Mechanism of Antitumor Responses and Autoimmunity in Patients Treated with CTLA-4 Blockade

2005 • 331 citations

Regulatory T-cell compartmentalization and trafficking

2006 • 323 citations

Inability of a Fusion Protein of IL-2 and Diphtheria Toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to Eliminate Regulatory T Lymphocytes in Patients With Melanoma

2005 • 293 citations

Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species

2003 • 289 citations

Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination

2005 • 282 citations

Immunity to cancer: attack and escape in T lymphocyte–tumor cell interaction

2002 • 280 citations

Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo

2005 • 250 citations

Tumor-Induced Immune Dysfunctions Caused by Myeloid Suppressor Cells

2001 • 245 citations

Regulatory T Cells in Ovarian Cancer: Biology and Therapeutic Potential

2005 • 239 citations

Characterization of human CD25⁺ CD4⁺ T cells in thymus, cord and adult blood

2002 • 232 citations

The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery

2003 • 179 citations

Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.

1995 • 169 citations

Tumor-Infiltrating Macrophages Induce Apoptosis in Activated CD8+ T Cells by a Mechanism Requiring Cell Contact and Mediated by Both the Cell-Associated Form of TNF and Nitric Oxide

2001 • 153 citations

Effective immunotherapy against cancer

2004 • 145 citations

Safety and efficacy of denileukin diftitox in patients with steroid-refractory acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

2004 • 143 citations

DAB389IL-2 (ONTAK): A Novel Fusion Toxin Therapy for Lymphoma

2000 • 120 citations

Nitric Oxide-Independent CTL Suppression during Tumor Progression: Association with Arginase-Producing (M2) Myeloid Cells

2003 • 108 citations

Myeloid progenitor cells mediate immune suppression in patients with head and neck cancers

1999 • 97 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 83 citations

Host immune response in renal cell cancer: Interleukin-4 (IL-4) and IL-10 mRNA are frequently detected in freshly collected tumor-infiltrating lymphocytes

1995 • 80 citations

Use of IL‐2 receptor antagonists to reduce delayed graft function following renal transplantation: a review

2005 • 47 citations

Diphtheria toxin conjugate therapy of cancer.

2002 • 32 citations

Modulation of antitumor responses by dendritic cells

2004 • 21 citations

Oxidative stress by tumor-derived macrophages suppresses the expression of CD 3 ζ chain of T cell receptor complex and antigen-specific T cell responses(担癌状態のマクロファージによる酸化ストレスに基づくT細胞受容体の構造異常と機能抑制)

1997 • 13 citations