Energy balance and cancer: the role of insulin and insulin-like growth factor-I

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Cancer Epidemiology and Prevention

2006 • 3,228 citations

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

1988 • 2,463 citations

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 • 2,010 citations

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

1998 • 1,850 citations

Nutritional Regulation of the Insulin-Like Growth Factors*

1994 • 1,537 citations

Cancer Epidemiology and Prevention

1997 • 1,433 citations

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

1999 • 1,128 citations

Menopausal Estrogen and Estrogen-Progestin Replacement Therapy and Breast Cancer Risk

2000 • 1,075 citations

Endometrial Carcinoma

1990 • 910 citations

Effect of Hormone Replacement Therapy on Breast Cancer Risk: Estrogen Versus Estrogen Plus Progestin

2000 • 879 citations

Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years

1998 • 856 citations

Insulin and colon cancer

1995 • 815 citations

The Insulin-Related Ovarian Regulatory System in Health and Disease

1999 • 797 citations

Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors

1996 • 783 citations

Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism

1997 • 725 citations

Endogenous Hormones and Breast Cancer Risk

1993 • 699 citations

Diabetes Mellitus as a Risk Factor for Pancreatic Cancer

1995 • 694 citations

Serum C-Peptide, Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins, and Colorectal Cancer Risk in Women

2000 • 653 citations

The role of oestrogens and progestagens in the epidemiology and prevention of breast cancer

1988 • 647 citations

Cancer Incidence in a Population-Based Cohort of Patients Hospitalized With Diabetes Mellitus in Denmark

1997 • 632 citations

Insulin-Like Growth Factor 1 and Prostate Cancer Risk: A Population-Based, Case-Control Study

1998 • 592 citations

Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels

1990 • 567 citations

Insulin-like Growth Factor Binding Protein-1: Recent Findings and New Directions

1997 • 532 citations

The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk

1988 • 529 citations

Diet, Body Size, and Breast Cancer

1993 • 497 citations

Increased Blood Glucose and Insulin, Body Size, and Incident Colorectal Cancer

1999 • 496 citations

Insulin Regulates the Serum Levels of Low Molecular Weight Insulin-Like Growth Factor-Binding Protein*

1988 • 489 citations

Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk?

1994 • 480 citations

Sex Hormones and Age: A Cross-sectional Study of Testosterone and Estradiol and Their Bioavailable Fractions in Community-dwelling Men

1998 • 477 citations

Obesity and cancer risk: a danish record-linkage study

1994 • 446 citations

Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males.

1996 • 431 citations

Testosterone at High Concentrations Interacts with the Human Androgen Receptor Similarly to Dihydrotestosterone*

1990 • 428 citations

Prospective Study of Adult Onset Diabetes Mellitus (Type 2) and Risk of Colorectal Cancer in Women

1999 • 426 citations

Abnormal Glucose Metabolism and Pancreatic Cancer Mortality

2000 • 412 citations

Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features.

1996 • 408 citations

A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women.

2000 • 407 citations

Plasma Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-Binding Proteins, and Prostate Cancer Risk: a Prospective Study

2000 • 403 citations

Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer

1999 • 398 citations

Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer.

1997 • 395 citations

Nutritional Regulation of IGF-I and IGF Binding Proteins

1991 • 389 citations

Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone

1997 • 380 citations

Growth Factors in Breast Cancer

1995 • 378 citations

Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia

1997 • 376 citations

Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay.

1995 • 371 citations

Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*

1981 • 369 citations

Insulin resistance and breast‐cancer risk

1992 • 366 citations

Nutrition, hormones, and breast cancer: Is insulin the missing link?

1996 • 358 citations

Insulin-Like Growth Factors: A Role in Growth Hormone Negative Feedback and Body Weight Regulation via Brain

1983 • 354 citations

Free insulin-like growth factors in human obesity

1995 • 350 citations

Serum insulin-like growth factor-I and breast cancer

2000 • 347 citations

The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism

1988 • 343 citations

Effect of obesity and body fat distribution on sex hormones and insulin in men

1991 • 336 citations

Cancer risk in patients with diabetes mellitus

1991 • 331 citations

A case-control study of diabetes mellitus and cancer risk

1994 • 329 citations

The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins.

1992 • 329 citations

Regulation of prostatic growth and function by peptide growth factors

1996 • 313 citations

Physical activity and reduced risk of colon cancer: implications for prevention.

1997 • 312 citations

Insulin and related factors in premenopausal breast cancer risk

1998 • 309 citations

Physical activity and cancer etiology: associations and mechanisms.

1998 • 306 citations

Insulin Resistance, Body Fat Distribution, and Sex Hormones in Men

1994 • 299 citations

The Role of the Insulin-like Growth Factor System in Human Cancer

1996 • 295 citations

Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice

2000 • 280 citations

Testosterone, body composition and aging.

1999 • 278 citations

Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer

1993 • 276 citations

Colorectal Cancer: Another Complication of Diabetes Mellitus?

1998 • 275 citations

Physical training and insulin sensitivity

1986 • 267 citations

Body size in different periods of life, diabetes mellitus, hypertension, and risk of postmenopausal endometrial cancer (Sweden).

2000 • 266 citations

Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men.

1996 • 264 citations

Dietary and Nutritional Factors and Pancreatic Cancer: a Case-Control Study Based on Direct Interviews

1998 • 263 citations

Nutrition and prostate cancer

1996 • 256 citations

Diet, body size, physical activity, and the risk of endometrial cancer.

1997 • 254 citations

Chronic anovulation syndrome and associated neoplasia.

1983 • 250 citations

A Meta-analysis of Body Mass Index and Risk of Premenopausal Breast Cancer

1995 • 248 citations

Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects.

1995 • 242 citations

Abdominal Obesity and the Metabolic Syndrome

1992 • 240 citations

Responses of the Growth Hormone (GH) and Insulin-Like Growth Factor Axis to Exercise, GH Administration, and GH Withdrawal in Trained Adult Males: A Potential Test for GH Abuse in Sport¹

1999 • 237 citations

Endogenous estrogen and postmenopausal breast cancer: a quantitative review.

1997 • 236 citations

The ratio between serum levels of insulin‐like growth factor (IGF)‐I and the IGF binding proteins (IGFBP‐1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients

1994 • 232 citations

Subsequent cancer risk in the incidence cohort of Rochester, Minnesota, residents with diabetes mellitus

1982 • 231 citations

Relationship of sex hormones to lipids and lipoproteins in nondiabetic men.

1993 • 229 citations

Insulin-Like Growth Factors in the Fed and Fasted States*

1982 • 228 citations

Diabetes mellitus and cancer risk: A multisite case-control study

1985 • 224 citations

Insulin‐like growth‐factor‐binding protein 3 is decreased in early‐stage operable pre‐menopausal breast cancer

1995 • 219 citations

Insulin-like Growth Factor-binding Protein (IGFBP-3) Predisposes Breast Cancer Cells to Programmed Cell Death in a Non-IGF-dependent Manner

1997 • 219 citations

Cancer incidence in the National Health and Nutrition Survey I. Follow-up data: diabetes, cholesterol, pulse and physical activity.

1995 • 216 citations

Obesity, body fat distribution and sex hormones in men.

1993 • 211 citations

Endogenous sex hormones and prostate cancer: a quantitative review of prospective studies

1999 • 211 citations

Pathophysiology of sex hormone binding globulin (SHBG): Relation to insulin

1991 • 209 citations

Insulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast.

1998 • 209 citations

Insulin-like Growth Factor (IGF)-binding Protein 5 Forms an Alternative Ternary Complex with IGFs and the Acid-labile Subunit

1998 • 199 citations

Serum androgens and sex hormone-binding globulins in relation to lifestyle factors in older African-American, white, and Asian men in the United States and Canada.

1995 • 199 citations

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.

1994 • 195 citations

Ventilation in Homes and Bronchial Obstruction in Young Children

1999 • 192 citations

Effect of brief exercise on circulating insulin-like growth factor I

1994 • 191 citations

IGF-I and IGF-II in relation to colorectal cancer

1999 • 190 citations

Risk Factors for Pancreatic Cancer: An Exploratory Study

1993 • 189 citations

Risk of endometrial and breast cancer in patients with diabetes mellitus

1997 • 188 citations

DIET‐INDUCED CHANGES IN SEX HORMONE BINDING GLOBULIN AND FREE TESTOSTERONE IN WOMEN WITH NORMAL OR POLYCYSTIC OVARIES: CORRELATION WITH SERUM INSULIN AND INSULIN‐LIKE GROWTH FACTOR‐I

1989 • 185 citations

Effect of body weight reduction on plasma androgens in obese, infertile women

1982 • 184 citations

INSULIN ACTION IN THE POLYCYSTIC OVARY SYNDROME

1999 • 183 citations

Effect of Fasting on Insulin-Like Growth Factor-I (IGF-I) and Growth Hormone Receptor mRNA Levels and IGF-I Gene Transcription in Rat Liver

1990 • 182 citations

Energy balance and cancer: the role of sex hormones

2001 • 179 citations

The distal axis of growth hormone (GH) in nutritional disorders: GH-binding protein, insulin-like growth factor-I (IGF-I), and IGF-I receptors in obesity and anorexia nervosa

1992 • 179 citations

Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion.

2000 • 174 citations

Diabetes, Body Size, and Risk of Endometrial Cancer

1998 • 171 citations

Recreational and Occupational Physical Activities and Risk of Breast Cancer

1998 • 170 citations

Physiology of Growth Hormone Secretion and Action

1992 • 169 citations

Multiple Endocrine Abnormalities of the Growth Hormone and Insulin-Like Growth Factor Axis in Patients with Anorexia Nervosa: Effect of Short- and Long-Term Weight Recuperation¹

1997 • 167 citations

Anthropometry and breast cancer. Body size-a moving target

1994 • 165 citations

Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in long-term training

1999 • 162 citations

Reduced growth of human breast cancer xenografts in hosts homozygous for the lit mutation.

1996 • 160 citations

Nutritional regulation of hormones and growth factors that control mammalian growth

1994 • 159 citations

Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features

1996 • 157 citations

Increased physical activity and the growth hormone-IGF-I axis in adolescent males

1998 • 157 citations

Relationship between circulating insulin-like growth factor components and sex hormones in a population-based sample of 50- to 80-year-old men and women.

1996 • 156 citations

The relationship between insulin-like growth factor-I, adiposity, and aging

1990 • 156 citations

EFFECT OF INSULIN-LIKE GROWTH FACTOR-TYPE I (IGF-I) AND INSULIN ON THE SECRETION OF SEX HORMONE BINDING GLOBULIN AND IGF-I BINDING PROTEIN (IBP-I) BY HUMAN HEPATOMA CELLS

1990 • 155 citations

Alterations in the Growth Hormone-Insulin-Like Growth Factor Axis in Insulin Dependent Diabetes Mellitus

1999 • 151 citations

The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins

1992 • 150 citations

Diabetes mellitus and colorectal cancer risk.

1997 • 149 citations

Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice

1997 • 146 citations

Insulin-Like Growth Factor-I in Relation to Premenopausal Ductal Carcinoma in Situ of the Breast

1998 • 146 citations

Diabetes mellitus and risk of prostate cancer (United States).

1998 • 146 citations

Biological Effects of Dietary Restriction

1991 • 144 citations

Diabetes mellitus and pancreatic cancer mortality in a prospective cohort of United States adults.

1998 • 140 citations

Weight control and its beneficial effect on fertility in women with obesity and polycystic ovary syndrome

1997 • 140 citations

BASIC COUNTERPOINT: Mechanisms and Pathways of Gonadal Steroid Modulation of Growth Hormone Secretion*

1992 • 133 citations

Differential effects of insulin and insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma-derived (Hep G2) cells.

1995 • 131 citations

Testosterone, Growth Hormone and IGF-I Responses to Acute and Chronic Resistive Exercise in Men Aged 55-70 Years

1995 • 130 citations

Growth Hormone (GH) Regulation of Cytochrome P-450IIC12, Insulin-Like Growth Factor-I (IGF-I), and GH Receptor Messenger RNA Expression in Primary Rat Hepatocytes: A Hormonal Interplay with Insulin, IGF-I, and Thyroid Hormone

1990 • 128 citations

Responses of IGF-I to endogenous increases in growth hormone after heavy-resistance exercise

1995 • 128 citations

Effect of insulin on the insulin-like growth factor system in children with new-onset insulin-dependent diabetes mellitus.

1995 • 127 citations

Insulinlike growth factors and binding proteins in colon cancer

1993 • 126 citations

Insulin-like growth factors in endometrial function

1998 • 125 citations

Exercise‐induced changes in insulin‐like growth factors and their low molecular weight binding protein in healthy subjects and patients with growth hormone deficiency

1990 • 125 citations

Insulin-like growth factor binding protein-3 proteolysis in children with insulin-dependent diabetes mellitus: a possible role for insulin in the regulation of IGFBP-3 protease activity.

1995 • 123 citations

Leptin and insulin growth factor I in relation to breast cancer (Greece).

2000 • 122 citations

Post-Challenge Glucose Concentration, Impaired Glucose Tolerance, Diabetes, and Cancer Mortality in Men

1992 • 120 citations

Breast cancer risk in young women and history of selected medical conditions

1999 • 118 citations

The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone

1994 • 118 citations

Disturbances in growth hormone secretion and action in adolescents with anorexia nervosa

1994 • 116 citations

Direct stimulatory effects of insulin-like growth factor-I on Leydig cell steroidogenesis in primary culture

1986 • 115 citations

Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men

1996 • 115 citations

Fatty acids, hyperinsulinemia, and insulin resistance: which comes first?

1994 • 115 citations

Influence of intensive exercise on insulin-like growth factor I, thyroid and steroid hormones in female gymnasts.

1991 • 113 citations

The Pituitary-Gonadal Axis and Health in Elderly Men: A Study of Men Born in 1913

1996 • 113 citations

Insulin-Like Growth Factor-I Selectively Stimulates Cholesterol Side-Chain Cleavage Expression in Ovarian Theca-lnterstitial Cells

1990 • 113 citations

Endometrial carcinoma; ovarian dysfunction — a risk factor in young women

1991 • 112 citations

Low concentrations of insulin-like growth factor-I in abdominal obesity.

1993 • 109 citations

Effects of gender on exercise-induced growth hormone release

1999 • 108 citations

Caloric restriction as a mechanism mediating resistance to environmental disease.

1998 • 107 citations

Occurrence, trends and environmental etiology of pancreatic cancer

1998 • 106 citations

Insulin-Like Growth Factors Augment Steroid Production and Expression of Steroidogenic Enzymes in Human Fetal Adrenal Cortical Cells: Implications for Adrenal Androgen Regulation¹

1997 • 105 citations

Induction of steroidogenic enzyme genes by insulin and IGF-I in cultured adult human adrenocortical cells

1997 • 103 citations

Breast cancer among former college athletes compared to non-athletes: a 15-year follow-up

2000 • 102 citations

Multiple Endocrine Abnormalities of the Growth Hormone and Insulin-Like Growth Factor Axis in Patients with Anorexia Nervosa: Effect of Short- and Long-Term Weight Recuperation

1997 • 102 citations

Regulation of hepatic growth hormone receptors by insulin

1978 • 102 citations

The Influence of Medical Conditions Associated with Hormones on the Risk of Breast Cancer

1993 • 101 citations

Effect of marathon run on serum IGF-I and IGF-binding protein 1 and 3 levels

1996 • 101 citations

Effect of caloric restriction on age-associated cancers

1992 • 101 citations

Influence of thyroid hormones on the regulation of growth hormone secretion

1995 • 95 citations

Anthropometric and reproductive factors and the risk of pancreatic cancer: A case-control study in Shanghai, China

1996 • 95 citations

Serum concentrations of free and total insulin‐like growth factor‐I, IGF binding proteins ‐1 and‐3 and IGFBP‐3 protease activity in boys with normal or precocious puberty

1996 • 95 citations

Glucocorticoids and insulin regulate expression of the human gene for insulin-like growth factor-binding protein-1 through proximal promoter elements.

1994 • 94 citations

Free Insulin-Like Growth Factor I (IGF-I) in Healthy Subjects: Relationship with IGF-Binding Proteins and Insulin Sensitivity

1997 • 93 citations

Responses of total and free insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 after resistance exercise and training in elderly subjects

1999 • 92 citations

Fasting affects serum insulin-like growth factors (IGFs) and IGF-binding proteins differently in patients with noninsulin-dependent diabetes mellitus versus healthy nonobese and obese subjects.

1994 • 91 citations

Diabetes and endometrial cancer: An Italian case-control study

1999 • 91 citations

Caloric restriction and experimental carcinogenesis

1999 • 91 citations

Effect of Exercise on Cytokines and Growth Mediators in Prepubertal Children

1999 • 90 citations

Insulin and Endometrial Cancer

1997 • 89 citations

Low Plasma Somatomedin-C in Streptozotocin-induced Diabetes Mellitus: Correlation with Changes in Somatogenic and Lactogenic Liver Binding Sites

1983 • 89 citations

Regulation of Sex Hormone Binding Globulin (SHBG) production in hep G2 cells by insulin

1988 • 88 citations

Decreased Androgen Levels and Obesity in Men

1996 • 85 citations

Energy intake, overweight, physical exercise and colorectal cancer risk

1999 • 85 citations

The effect of fasting on liver receptors for prolactin and growth hormone

1981 • 84 citations

Insulin Resistance and Obesity: The role of fat distribution pattern

1996 • 84 citations

Increased Circulating Levels of Insulin-Like Growth Factor-I and Decreased Circulating Levels of Insulin-Like Growth Factor Binding Protein-1 in Postmenopausal Women with Endometrial Cancer.

1997 • 82 citations

Insulin-Like Growth Factors, Insulin-Like Growth Factor Binding Proteins and Ovarian Androgen Production

1994 • 82 citations

Differentiation of ovarian theca-interstitial cells in vitro: regulation of 17 alpha-hydroxylase messenger ribonucleic acid expression by luteinizing hormone and insulin-like growth factor-I.

1993 • 81 citations

Nutrition and endometrial cancer

1996 • 80 citations

Insulin Resistance in Obesity: Metabolic Mechanisms and Measurement Methods

1998 • 80 citations

Is Diabetes Mellitus Associated with Prostate Cancer Incidence and Survival?

1999 • 80 citations

Insulin Regulation of Insulin-Like Growth Factor-Binding Protein Production in Cultured HepG2 Cells*

1990 • 79 citations

Insulin-Like Growth Factors Augment Steroid Production and Expression of Steroidogenic Enzymes in Human Fetal Adrenal Cortical Cells: Implications for Adrenal Androgen Regulation

1997 • 78 citations

Insulin Regulates the Expression of the Insulin-Like Growth Factor Binding Protein 2 mRNA in Rat Hepatocytes

1990 • 78 citations

A population‐based case‐control study of endometrial cancer in shanghai, china

1991 • 78 citations

Insulin-like growth factors and their binding proteins before and after weight loss and their associations with hormonal and metabolic parameters in obese adolescent girls.

1996 • 77 citations

THE EFFECT OF WEIGHT LOSS ON SEX STEROID SECRETION AND BINDING IN MASSIVELY OBESE WOMEN

1981 • 75 citations

Plasma Insulin-Like Growth Factor-I and High Affinity Growth Hormone-Binding Protein Levels Increase After Two Weeks of Strenuous Physical Training

1997 • 74 citations

Growth Hormone and Nutrition

1992 • 73 citations

Recovery of Growth Hormone Release from Suppression by Exogenous Insulin-Like Growth Factor I (IGF-I): Evidence for a Suppressive Action of Free Rather Than Bound IGF-I1

1998 • 73 citations

Insulin-Like Growth Factor-I Stimulates the Expression of 3β-Hydroxysteroid Dehydrogenase Messenger Ribonucleic Acid in Ovarian Theca-Interstitial Cells1

1993 • 72 citations

Successful 6-Month Endurance Training Does Not Alter Insulin-Like Growth Factor-I in Healthy Older Men and Women

1997 • 71 citations

Sex Steroid Regulation of Growth Hormone Secretion and Action

1996 • 70 citations

Suppressed expression of insulin‐like growth factor binding protein‐1 mRNA in the endometrium: A molecular mechanism associating endometrial cancer with its risk factors

1994 • 70 citations

A case-control study of uterine endometrial cancer of pre- and post-menopausal women.

2000 • 69 citations

Insulin-Like Growth Factor Type I Increases Concentrations of Messenger Ribonucleic Acid Encoding Cytochrome P450 Cholesterol Side-Chain Cleavage Enzyme in Primary Cultures of Porcine Granulosa Cells*

1990 • 69 citations

Igf system components as prognostic markers in breast cancer

1998 • 68 citations

Role of dihydrotestosterone in androgen action

1996 • 67 citations

Influence of tamoxifen on sex hormones, gonadotrophins and sex hormone binding globulin in postmenopausal breast cancer patients

1995 • 67 citations

Membrane-associated Insulin-like Growth Factor-binding Protein-3 Inhibits Insulin-like Growth Factor-I-induced Insulin-like Growth Factor-I Receptor Signaling in Ishikawa Endometrial Cancer Cells

1997 • 65 citations

Influence of exercise duration on serum insulin-like growth factor and its binding proteins in athletes

1998 • 65 citations

Changes in circulating insulin-like growth factor-binding protein-1 (IGFBP-1) during prolonged exercise: effect of carbohydrate feeding.

1994 • 64 citations

Regulation of testicular function by insulin and transforming growth factor-β

1990 • 64 citations

Leptin and IGF-I levels in unconditioned male volunteers after short-term exercise

2000 • 64 citations

Exercise-induced changes in circulating growth factors with cyclic variation in plasma estradiol in women

1997 • 57 citations

Transcriptional Regulation of the Lutropin/Human Choriogonadotropin Receptor and Three Enzymes of Steroidogenesis by Growth Factors in Cultured Pig Leydig Cells

1996 • 57 citations

Insulin Resistance, Polycystic Ovary Syndrome and Metformin

1999 • 57 citations

Short-term exposure to insulin-like growth factors stimulates testosterone production by testicular interstitial cells

1987 • 57 citations

Serum levels of insulin‐like growth factor I and insulin‐like growth factor‐binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle‐aged men

1996 • 55 citations

Insulin-like growth factor binding protein-3 proteolysis in children with insulin-dependent diabetes mellitus: a possible role for insulin in the regulation of IGFBP-3 protease activity

1995 • 54 citations

Growth hormone receptors in rat liver membranes: Effects of fasting and refeeding, and correlation with plasma somatomedin activity

1982 • 53 citations

Hyperinsulinism and sex hormones in young adult African Americans

1999 • 51 citations

Lack of stimulation of 24-hour growth hormone release by hypocaloric diet in obesity.

1995 • 48 citations

Insulin-Like Growth Factor-I-Mediated Amplification of Follicle-Stimulating Hormone-Supported Progesterone Accumulation by Cultured Rat Granulosa Cells: Enhancement of Steroidogenic Enzyme Activity and Expression1

1997 • 48 citations

INSULIN-LOWERING THERAPEUTIC MODALITIES FOR POLYCYSTIC OVARY SYNDROME

1999 • 47 citations

RELATIONS BETWEEN IMMUNOREACTIVE SOMATOMEDIN C, INSULIN AND T3 PATTERNS DURING FASTING IN OBESE SUBJECTS

1984 • 44 citations

Twenty-Four-Hour Serum Growth Hormone, Insulin, C-Peptide and Blood Glucose Profiles and Serum Insulin-Like Growth Factor-l Concentrations in Women with Polycystic Ovaries

1992 • 43 citations

Growth Hormone Insulin-Like Growth Factor I Axis in Insulin-Dependent Diabetes mellitus

1996 • 42 citations

Study of Insulin-Like Growth Factor I in Human Obesity

1991 • 40 citations

Hormonal Changes in Elderly Men with Non-Insulin-Dependent Diabetes mellitus and the Hormonal Relationships to Abdominal Adiposity

1994 • 40 citations

Enhancement of susceptibility to diverse skin tumor promoters by activation of the insulin-like growth factor-1 receptor in the epidermis of transgenic mice

1999 • 40 citations

Influence of physical activity on plasma insulin-like growth factor-1 and insulin-like growth factor binding proteins in healthy older women

1999 • 39 citations

Fasting affects serum insulin-like growth factors (IGFs) and IGF- binding proteins differently in patients with noninsulin-dependent diabetes mellitus versus healthy nonobese and obese subjects

1994 • 37 citations

Physical exercise: a pillar for cancer prevention?

1998 • 36 citations

Growth hormone-binding proteins in plasma.

1993 • 35 citations

Interaction of physical activity and diet: implications for insulin-glucose dynamics

1999 • 32 citations

Changes in circulating insulin-like growth factor-binding protein-1 (IGFBP-1) during prolonged exercise: effect of carbohydrate feeding

1994 • 32 citations

Recovery of Growth Hormone Release from Suppression by Exogenous Insulin-Like Growth Factor I (IGF-I): Evidence for a Suppressive Action of Free Rather Than Bound IGF-I

1998 • 32 citations

The effect of synthetic very low calorie diets on the GH-IGF-1 axis in obese subjects

1990 • 29 citations

Regulation of primary response and specific genes in adrenal cells by peptide hormones and growth factors

1996 • 28 citations

Characteristics of the somatotropic axis in insulin dependent diabetes mellitus.

1995 • 28 citations

Effects of exercise during normoxia and hypoxia on the growth hormone?insulin-like growth factor I axis

1995 • 28 citations

Clinical Actions of Growth Hormone

1992 • 23 citations

Growth Hormone and Insulin-Like Growth Factor I Responses to Moderate Submaximal Acute Physical Exercise in Man: Effects of Octreotide, a Somatostatin Analogue, Administration

1997 • 22 citations

Basic counterpoint: mechanisms and pathways of gonadal steroid modulation of growth hormone secretion

1992 • 21 citations

Family Histories of Diabetes Mellitus and Breast Cancer and Incidence of Postmenopausal Breast Cancer

1998 • 17 citations

Changes in somatomedin activity in anorexia nervosa.

1985 • 15 citations

Body Composition Assessed by Bioelectrical Impedance Analysis (BIA) and the Correlation with Plasma Insulin-Like Growth Factor I (IGF-I) in Normal Japanese Subjects and Patients with Acromegaly and GH Deficiency.

1994 • 14 citations

Evaluation of disease activity by IGF-I and IGF binding protein-3 (IGFBP3) in acromegaly patients distributed according to a clinical score

1999 • 13 citations

Somatotropic axis and body weight in pre-menopausal and post-menopausal women: evidence for a neuroendocrine derangement, in absence of changes of insulin-like growth factor binding protein concentrations

1998 • 13 citations

Insulin-Like Growth Factor Binding Protein-1: Identification, Purification, and Regulation in Fetal and Adult Life

1994 • 12 citations

Influence of acute and chronic exercise on insulin-like growth factor-I in healthy active elderly men and women

1999 • 12 citations

In vivo regulation of the steroidogenic activity of rat luteal cells by insulin

1995 • 11 citations