Transcriptional Regulation of the Lutropin/Human Choriogonadotropin Receptor and Three Enzymes of Steroidogenesis by Growth Factors in Cultured Pig Leydig Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Radioimmunoassay for Cyclic Nucleotides

1972 • 2,057 citations

Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein-Coupled Receptor Family

1989 • 955 citations

Cell-Cell Interactions in the Testis*

1991 • 660 citations

Leydig Cells: Endocrine, Paracrine, and Autocrine Regulation

1994 • 613 citations

Cloning and Sequencing of Porcine LH-hCG Receptor cDNA: Variants Lacking Transmembrane Domain

1989 • 568 citations

Northern blot normalization with a 28S rRNA olinucleotide probe

1989 • 364 citations

Full Length cDNA Structure and Deduced Amino Acid Sequence of Human β-Hydroxy-5-Ene Steroid Dehydrogenase

1989 • 314 citations

Endocrine Regulation and Communicating Functions of the Leydig Cell

1988 • 267 citations

Radioimmunoassay of Epidermal Growth Factor

1972 • 226 citations

Characterization of Insulin and Insulin-Like Growth Factor I Receptors of Purified Leydig Cells and Their Role in Steroidogenesis in Primary Culture: A Comparative Study*

1986 • 212 citations

Bovine adrenocortical cytochrome P-450(17 alpha). Regulation of gene expression by ACTH and elucidation of primary sequence.

1986 • 211 citations

Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex.

1984 • 208 citations

Total and Unbound Testosterone Levels in the Newborn and in Normal and Hypogonadal Children: Use of a Sensitive Radioimmunoassay for Testosterone

1973 • 189 citations

Multiple Mechanisms for Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ⁵→Δ⁴-Isomerase, 17α-Hydroxylase/C_17–20Lyase Cytochrome P450, and Cholesterol Side-Chain Cleavage Cytochrome P450 Messenger Ribonucleic Acid Levels in Primary Cultures of Mouse Leydig Cells^*

1991 • 143 citations

Regulation of gonadotropin receptors, gonadotropin responsiveness, and cell multiplication by somatomedin‐C and insulin in cultured pig Leydig cells

1986 • 137 citations

Basic fibroblast growth factor (bFGF) gene expression and protein production during pubertal development of the seminiferous tubule: follicle-stimulating hormone-induced Sertoli cell bFGF expression.

1992 • 120 citations

Transforming growth factor β inhibits Leydig cell functions

1987 • 109 citations

On the mechanisms involved in the regulation of the cell-surface receptors for human choriogonadotropin and mouse epidermal growth factor in cultured Leydig tumor cells.

1983 • 106 citations

Transforming growth factor-beta (beta 1, beta 2, and beta 3) gene expression and action during pubertal development of the seminiferous tubule: potential role at the onset of spermatogenesis.

1993 • 106 citations

Transforming growth factor-β inhibits Leydig cell steroidogenesis in primary culture

1987 • 102 citations

Identification of Epidermal Growth Factor-Like Activity in Human Male Reproductive Tissues and Fluids*

1984 • 95 citations

Mechanism of the Inhibitory Action of Epidermal Growth Factor on Testicular Androgen Biosynthesis in Vitro*

1982 • 93 citations

Isolation and partial characterization of basic fibroblast growth factor from bovine testis

1987 • 93 citations

Somatomedin C/insulin-like growth factor 1 as a possible intratesticular regulator of Leydig cell activity

1987 • 91 citations

Insulin-like growth factor-I augments gonadotropin-stimulated androgen biosynthesis by cultured rat testicular cells

1987 • 82 citations

Stimulatory effects of epidermal growth factor on steroidogenesis in Leydig cells

1986 • 78 citations

11 Structure, regulation and role of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues

1994 • 78 citations

A Rat Sertoli Cell Factor Similar to Basic Fibroblast Growth Factor Increases c-fos Messenger Ribonucleic Acid in Cultured Sertoli Cells

1989 • 74 citations

Expression and regulation of transforming growth factor-beta 1 messenger ribonucleic acid and protein in cultured porcine Leydig and Sertoli cells.

1994 • 71 citations

Epidermal Growth Factor Receptor Localization in the Rat and Monkey Testes1

1989 • 66 citations

Regulation of testicular function by insulin and transforming growth factor-β

1990 • 64 citations

Transforming growth factor β treatment decreases ACTH receptors on ovine adrenocortical cells

1989 • 61 citations

Characterization and regulation of somatomedin‐C/insulin‐like growth factor I (Sm‐C/IGF‐I) receptors on cultured pig Leydig cells

1987 • 61 citations

Epidermal Growth Factor Directly Stimulates Steroidogenesis in Primary Cultures of Porcine Leydig Cells: Actions and Sites of Action*

1991 • 59 citations

Fibroblast Growth Factor Inhibits Luteinizing Hormone-Stimulated Androgen Production by Cultured Rat Testicular Cells*

1988 • 57 citations

Transforming growth factor-beta (beta 1, beta 2, and beta 3) gene expression and action during pubertal development of the seminiferous tubule: potential role at the onset of spermatogenesis

1993 • 56 citations

Immunohistochemical localization of transforming growth factor-β1 in the fetal and neonatal rat testis

1994 • 56 citations

Transforming Growth Factor-β Inhibits Steroid 17α-Hydroxylase Cytochrome P-450 Expression in Ovine Adrenocortical Cells*

1990 • 55 citations

Epidermal growth factor activates steroid biosynthesis in cultured Leydig tumor cells without affecting the levels of cAMP and potentiates the activation of steroid biosynthesis by choriogonadotropin and cAMP.

1987 • 52 citations

Regulation of 3β-Hydroxysteroid Dehydrogenase in Adrenocortical Cells: Effects of Angiotensin-II and Transforming Growth Factor Beta

1991 • 51 citations

Expression of testicular 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase: regulation by luteinizing hormone and forskolin in Leydig cells of adult rats.

1992 • 51 citations

Immunocytochemical Localization of the Epidermal Growth Factor Receptor in Mouse Testis

1990 • 48 citations

Cell lineage specificity of expression of the murine transforming growth factor beta 3 and transforming growth factor beta 1 genes.

1991 • 46 citations

Epidermal growth factor, a phorbol ester, and 3',5'-cyclic adenosine monophosphate decrease the transcription of the luteinizing hormone/chorionic gonadotropin receptor gene in MA-10 Leydig tumor cells.

1992 • 45 citations

Effects of Insulin‐like Growth Factor‐I on Androgen Production by Highly Purified Pubertal and Adult Rat Leydig Cells

1992 • 42 citations

Stimulation of aromatase activity in immature porcine Leydig cells by fibroblast growth factor (FGF)

1988 • 41 citations

Fibroblast growth factor is a regulator of testosterone secretion in cultured immature Leydig cells

1988 • 38 citations

Multiple isoforms of 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase in mouse tissues: male-specific isoforms are expressed in the gonads and liver.

1993 • 37 citations

On the mechanisms involved in the inhibitory and stimulating actions of transforming growth factor-β on porcine testicular steroidogenesis: an in vitro study

1989 • 35 citations

Epidermal growth factor and phorbol esters reduce the levels of the cognate mRNA for the LH/CG receptor

1991 • 35 citations

Fibroblast growth factor inhibits 5α-reductase activity in cultured immature Leydig cells

1990 • 34 citations

A Growth Factor in Bovine and Human Testes Structurally Related to Basic Fibroblast Growth Factor

1988 • 32 citations

Growth hormone and insulin-like growth factor I stimulate Leydig cell steroidogenesis

1989 • 31 citations

Basic fibroblast growth factor inhibits Δ5-3β-hydroxysteroid dehydrogenase-isomerase activity in cultured immature Leydig cells

1990 • 28 citations

Expression of testicular 3 beta-hydroxysteroid dehydrogenase/delta 5---- 4-isomerase: regulation by luteinizing hormone and forskolin in Leydig cells of adult rats

1992 • 27 citations

Regulation of the Differentiated Functions of Leydig Tumor Cells by Epidermal Growth Factor^a

1989 • 27 citations

Sites of interaction between epidermal growth factor and transforming growth factor-beta 1 in the control of steroidogenesis in cultured porcine Leydig cells.

1992 • 26 citations

The murine 3β-hydroxysteroid dehydrogenase multigene family: Structure, function and tissue-specific expression

1995 • 26 citations

Localization and characterization of epidermal growth factor receptors on human testicular tissue by biochemical and immunohistochemical techniques

1990 • 25 citations

Transcriptional and Post-transcriptional Regulation of Luteotropin/Chorionic Gonadotropin Receptor by the Agonist in Leydig Cells

1995 • 25 citations

Multiple isoforms of 3 beta-hydroxysteroid dehydrogenase/delta 5-->4- isomerase in mouse tissues: male-specific isoforms are expressed in the gonads and liver

1993 • 21 citations

Regulation by growth factors og leydig cell differentiated functions

1991 • 20 citations

Expression and regulation of transforming growth factor-beta 1 messenger ribonucleic acid and protein in cultured porcine Leydig and Sertoli cells

1994 • 19 citations

Processing of human choriogonadotropin and its receptors by cultured pig Leydig cells

1986 • 19 citations

Epidermal growth factor, a phorbol ester, and 3',5'-cyclic adenosine monophosphate decrease the transcription of the luteinizing hormone/chorionic gonadotropin receptor gene in MA-10 Leydig tumor cells

1992 • 14 citations

Sites of interaction between epidermal growth factor and transforming growth factor-beta 1 in the control of steroidogenesis in cultured porcine Leydig cells

1992 • 7 citations