Nutrition, hormones, and breast cancer: Is insulin the missing link?

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

Handbook of Physiology.

1960 • 10,428 citations

THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS

1963 • 5,061 citations

Glycemic index of foods: a physiological basis for carbohydrate exchange

1981 • 3,657 citations

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

1988 • 2,463 citations

Insulin Resistance in Essential Hypertension

1987 • 2,386 citations

Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices

1975 • 2,207 citations

Relation of Body Fat Distribution to Metabolic Complications of Obesity*

1982 • 1,919 citations

Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome

1989 • 1,858 citations

Estimates of the worldwide incidence of eighteen major cancers in 1985

1993 • 1,680 citations

Worldwide Variation in Human Growth

1991 • 1,496 citations

Reproductive Factors and Breast Cancer

1993 • 1,431 citations

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

Physical activity and incidence of non-insulin-dependent diabetes mellitus in women

1991 • 1,174 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

SEX‐HORMONE‐BINDING GLOBULIN

1974 • 1,119 citations

Effect of fatty acids on glucose production and utilization in man.

1983 • 1,056 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Estrogens, Progestogens, Normal Breast Cell Proliferation, and Breast Cancer Risk

1993 • 1,018 citations

Insulin‐like growth factors I and II

1990 • 1,006 citations

Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism.

1986 • 992 citations

Impaired Insulin Action in Puberty

1986 • 938 citations

POLYCYSTIC OVARIES—A COMMON FINDING IN NORMAL WOMEN

1988 • 926 citations

The Free Hormone Hypothesis: A Physiologically Based Mathematical Model*

1989 • 925 citations

Insulin-Like Growth Factors as Intraovarian Regulators of Granulosa Cell Growth and Function*

1985 • 921 citations

Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome

1992 • 908 citations

Insulin-Like Growth Factors

1997 • 897 citations

The Relation between Insulin Sensitivity and the Fatty-Acid Composition of Skeletal-Muscle Phospholipids

1993 • 839 citations

Insulin and colon cancer

1995 • 815 citations

Risk Factors for Coronary Artery Disease in Healthy Persons with Hyperinsulinemia and Normal Glucose Tolerance

1989 • 792 citations

Insulin Resistance — Mechanisms, Syndromes, and Implications

1991 • 788 citations

Dietary Factors and Risk of Breast Cancer: Combined Analysis of 12 Case--Control Studies

1990 • 763 citations

Insulin Resistance in Nonobese Patients with Polycystic Ovarian Disease*

1983 • 710 citations

Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture.

1988 • 703 citations

Endogenous Hormones and Breast Cancer Risk

1993 • 699 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

Inhibition of Sex Hormone-Binding Globulin Production in the Human Hepatoma (Hep G2) Cell Line by Insulin and Prolactin*

1988 • 682 citations

Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats

1987 • 658 citations

The role of oestrogens and progestagens in the epidemiology and prevention of breast cancer

1988 • 647 citations

A Prospective Study of Endogenous Estrogens and Breast Cancer in Postmenopausal Women

1995 • 635 citations

Worldwide Variation in Human Growth

1977 • 631 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Epidemiology and Long‐term Survival in Acromegaly: A Study of 166 Cases Diagnosed between 1955 and 1984

1988 • 591 citations

Characterization of Groups of Hyperaiidrogenic Women with Acanthosis Nigricans, Impaired Glucose Tolerance, and/or Hyperinsulinemia*

1987 • 590 citations

Relationship of Androgenic Activity to Body Fat Topography, Fat Cell Morphology, and Metabolic Aberrations in Premenopausal Women*

1983 • 589 citations

Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats

1991 • 586 citations

Binding proteins for the insulin-like growth factors: Structure, regulation and function

1989 • 565 citations

The Functions of Corticosteroid-Binding Globulin and Sex Hormone-Binding Globulin: Recent Advances*

1990 • 559 citations

POLYCYSTIC OVARY SYNDROME: A CHANGING PERSPECTIVE

1989 • 533 citations

The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk

1988 • 529 citations

Polycystic Ovary Syndrome as a Form of FunctionalOvarian Hyperandrogenism Due to Dysregulation ofAndrogen Secretion*

1995 • 508 citations

Diet, Body Size, and Breast Cancer

1993 • 497 citations

Insulin Regulates the Serum Levels of Low Molecular Weight Insulin-Like Growth Factor-Binding Protein*

1988 • 489 citations

Physical Exercise and Reduced Risk of Breast Cancer in Young Women

1994 • 480 citations

Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk?

1994 • 480 citations

EPIDEMIOLOGY OF ACROMEGALY IN THE NEWCASTLE REGION

1980 • 468 citations

Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17

1994 • 467 citations

Genetic and Nongenetic Determinants of Regional Fat Distribution

1993 • 464 citations

The Gonadotropic Function of Insulin*

1987 • 454 citations

HETEROGENEITY OF THE POLYCYSTIC OVARY SYNDROME: CLINICAL, ENDOCRINE AND ULTRASOUND FEATURES IN 556 PATIENTS

1989 • 447 citations

Premature Adrenarche - A Common Condition with Variable Presentation

2015 • 444 citations

Effects of Growth Hormone on Insulin Action in Man: Mechanisms of Insulin Resistance, Impaired Suppression of Glucose Production, and Impaired Stimulation of Glucose Utilization

1982 • 434 citations

The insulin receptor and the molecular mechanism of insulin action.

1988 • 426 citations

Menopause and Breast Cancer Risk<xref ref-type="fn" rid="FN2">2</xref>

1972 • 421 citations

ACROMEGALY

1987 • 419 citations

Reproductive Endocrinology: Physiology, Pathophysiology and Clinical Management.

1986 • 413 citations

Effects of dietary fat on postprandial substrate oxidation and on carbohydrate and fat balances.

1985 • 410 citations

Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women

1984 • 391 citations

Nutritional Regulation of IGF-I and IGF Binding Proteins

1991 • 389 citations

Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.

1966 • 388 citations

Effects of a Traditional Lifestyle on Obesity in Pima Indians

1994 • 387 citations

Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion

1995 • 386 citations

Puberty decreases insulin sensitivity

1987 • 376 citations

Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*

1981 • 369 citations

Insulin resistance and breast‐cancer risk

1992 • 366 citations

How common are polycystic ovaries in normal women and what is their significance for the fertility of the population?

1992 • 356 citations

Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men.

1993 • 351 citations

Failure of dietary fat intake to promote fat oxidation: a factor favoring the development of obesity

1989 • 351 citations

Dietary fat:carbohydrate ratio and obesity in middle-aged men

1988 • 348 citations

EFFECTS OF LOW-CARBOHYDRATE DIET AND DIABETES MELLITUS ON PLASMA CONCENTRATIONS OF GLUCOSE, NON-ESTERIFIED FATTY ACID, AND INSULIN DURING ORAL GLUCOSE-TOLERANCE TESTS

1963 • 345 citations

Energy intake and other determinants of relative weight

1988 • 344 citations

The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism

1988 • 343 citations

High-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults

1990 • 342 citations

Serum Sex Hormone Levels After Menopause and Subsequent Breast Cancer

1996 • 337 citations

INCREASED INCIDENCE OF CARCINOMA OF THE BREAST ASSOCIATED WITH ABDOMINAL ADIPOSITY IN POSTMENOPAUSAL WOMEN

1990 • 335 citations

The morphology and metabolism of intraabdominal adipose tissue in men

1992 • 334 citations

Cancer risk in patients with diabetes mellitus

1991 • 331 citations

The Effect of Growth Hormone on Glucose Metabolism and Insulin Secretion in Man*

1982 • 331 citations

The Glycemic Index1

2015 • 329 citations

A case-control study of diabetes mellitus and cancer risk

1994 • 329 citations

Insulin-Like Growth Factor I and Insulin Potentiate Luteinizing Hormone-Induced Androgen Synthesis by Rat Ovarian Thecal-Interstitial Cells*

1988 • 326 citations

Do regular ovulatory cycles increase breast cancer risk?

1985 • 326 citations

Diet composition, energy intake, and exercise in relation to body fat in men and women

1990 • 316 citations

Increased insulin secretion in puberty: A compensatory response to reductions in insulin sensitivity

1989 • 314 citations

Variations in Insulin-Stimulated Glucose Uptake in Healthy Individuals with Normal Glucose Tolerance*

1987 • 311 citations

Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism.

1993 • 307 citations

6 Factors controlling blood concentration of somatomedin C

1984 • 299 citations

Androgen-Estrogen Metabolism in Women with Upper BodyVersusLower Body Obesity*

1990 • 293 citations

Evidence for a single gene effect causing polycystic ovaries and male pattern baldness

1993 • 288 citations

The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries

1993 • 287 citations

Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women.

1995 • 282 citations

Physical factors Influencing postprandial glucose and insulin responses to starch

1980 • 281 citations

Insulin sensitivity, lipids, and body composition in childhood: is "syndrome X" present?

1996 • 272 citations

Physical training and insulin sensitivity

1986 • 267 citations

Food processing and the glycemic index

1985 • 266 citations

Testosterone Concentrations in Women and Men With NIDDM

1994 • 265 citations

On the Paradox of Insulin-Induced Hyperandrogenism in Insulin-Resistant States

1991 • 259 citations

A longitudinal analysis of accelerated weight gain in preschool children.

1995 • 258 citations

Gender and Tanner stage differences in body composition and insulin sensitivity in early pubertal children.

1995 • 251 citations

Chronic anovulation syndrome and associated neoplasia.

1983 • 250 citations

Acromegaly and gastrointestinal cancer

1991 • 249 citations

Effect of Family History, Body-Fat Distribution, and Reproductive Factors on the Risk of Postmenopausal Breast Cancer

1992 • 248 citations

A Meta-analysis of Body Mass Index and Risk of Premenopausal Breast Cancer

1995 • 248 citations

A pathogenic role of visceral fat beta 3-adrenoceptors in obesity.

1995 • 247 citations

Hyperandrogenic anovulation (PCOS): A unique disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus

1995 • 240 citations

A meta-analysis of studies of dietary fat and breast cancer risk

1993 • 236 citations

Insulin-Like Growth Factor Receptors

1991 • 235 citations

Progress in obesity research: 7

1996 • 235 citations

Abdominal Obesity and Physical Inactivity as Risk Factors for NIDDM and Impaired Glucose Tolerance in Indian, Creole, and Chinese Mauritians

1991 • 234 citations

Subsequent cancer risk in the incidence cohort of Rochester, Minnesota, residents with diabetes mellitus

1982 • 231 citations

Associations of Body Mass and Fat Distribution with Sex Hormone Concentrations in Postmenopausal Women

1991 • 228 citations

Pathophysiology of obesity

1992 • 228 citations

Relationship between diet composition and body fatness, with adjustment for resting energy expenditure and physical activity, in preadolescent children

1993 • 228 citations

Diurnal Rhythm of Growth Hormone-Independent Binding Protein for Insulin-like Growth Factors in Human Plasma*

1987 • 227 citations

Diabetes mellitus and cancer risk: A multisite case-control study

1985 • 224 citations

Dysregulation of cytochrome P450c17α as the cause of polycystic ovarian syndrome

1991 • 224 citations

Obesity as an adaptation to a high-fat diet: evidence from a cross-sectional study

1994 • 223 citations

4 Serum bioavailability of sex steroid hormones

1986 • 222 citations

Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1.

1991 • 221 citations

Dietary fat intake and weight gain in women genetically predisposed for obesity

1995 • 221 citations

Wholemeal versus wholegrain breads: proportion of whole or cracked grain and the glycaemic response.

1988 • 221 citations

Dietary fat and body fat: a multivariate study of 205 adult females

1992 • 218 citations

Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative Aging Study

1993 • 217 citations

Relation of prediagnostic serum estrogen and androgen levels to breast cancer risk.

1996 • 217 citations

Insulin-Like Growth Factor I: A Possible Metabolic Signal Involved in the Regulation of Female Puberty

1991 • 215 citations

Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals.

1990 • 214 citations

Insulin regulation of insulin-like growth factor binding protein-1 in obese and nonobese humans.

1992 • 210 citations

High-Fat, Low-Carbohydrate Diet and the Etiology of Non-Insulin-dependent Diabetes Mellitus: The San Luis Valley Diabetes Study

1991 • 209 citations

Importance of Raised Growth Hormone Levels in Mediating the Metabolic Derangements of Diabetes

1984 • 207 citations

Diet and Physical Activity as Determinants of Hyperinsulinemia: The Zutphen Elderly Study

1994 • 206 citations

Dysregulation of cytochrome P450c17α as the cause of polycystic ovarian syndrome

1990 • 201 citations

Diet and obesity

1985 • 201 citations

Abdominal Obesity and Breast Cancer Risk

1990 • 190 citations

ORCADIAN VARIATION OF GH‐INDEPENDENT IGF‐BINDING PROTEIN IN DIABETES MELLITUS AND ITS RELATIONSHIP TO INSULIN. A NEW ROLE FOR INSULIN?

1988 • 185 citations

DIET‐INDUCED CHANGES IN SEX HORMONE BINDING GLOBULIN AND FREE TESTOSTERONE IN WOMEN WITH NORMAL OR POLYCYSTIC OVARIES: CORRELATION WITH SERUM INSULIN AND INSULIN‐LIKE GROWTH FACTOR‐I

1989 • 185 citations

Effect of body weight reduction on plasma androgens in obese, infertile women

1982 • 184 citations

Insulin-like growth factors; autocrine, paracrine or endocrine? New perspectives of the somatomedin hypothesis in the light of recent developments

1989 • 182 citations

Dietary supplementation of omega-3 polyunsaturated fatty acids improves insulin sensitivity in non-insulin-dependent diabetes.

1987 • 180 citations

Sugar and body weight regulation

1995 • 180 citations

Habitual dietary intake and insulin sensitivity in lean and obese adults

1992 • 176 citations

INSULIN DIFFERENTIALLY ALTERS TRANSCAPILLARY MOVEMENT OF INTRAVASCULAR IGFBP-1, IGFBP-2 AND ENDOTHELIAL CELL IGF-BINDING PROTEINS IN THE RAT HEART

1990 • 175 citations

The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women

1994 • 173 citations

Glycemic Response to Wheat Products: Reduced Response to Pasta but No Effect of Fiber

1983 • 173 citations

Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford Coronary Risk Intervention Project Investigators and Staff.

1991 • 172 citations

Hormones and Breast Cancer

1966 • 171 citations

Insulin resistance: an adaptation for weight maintenance

1992 • 169 citations

On the regulation of sex-hormone-binding globulin—A challenge of an old dogma and outlines of an alternative mechanism

1989 • 167 citations

Usual Dietary Fat Intake and Insulin Concentrations in Healthy Women Twins

1993 • 166 citations

Westernisation, insulin resistance and diabetes in Australian Aborigines

1991 • 165 citations

Physiologic Basis for the Control of Body Fat Distribution in Humans

1989 • 164 citations

SEX HORMONE LEVELS IN SERUM IN RELATION TO THE DEVELOPMENT OF BREAST CANCER

1987 • 164 citations

Colonie Polyps in Patients with Acromegaly

1982 • 162 citations

Studies on the Mechanism of Activation of Adipose Tissue Pyruvate Dehydrogenase by Insulin

1973 • 162 citations

Nutritional regulation of hormones and growth factors that control mammalian growth

1994 • 159 citations

Both Human Pituitary Growth Hormone and Recombinant DNA-Derived Human Growth Hormone Cause Insulin Resistance at a Postreceptor Site*

1982 • 158 citations

The relationship between insulin-like growth factor-I, adiposity, and aging

1990 • 156 citations

Effect of Diet Composition on the Hyperinsulinemia of Obesity

1971 • 155 citations

Adrenal Androgen Hyperresponsiveness to Adrenocorticotropin in Women with Acne and/or Hirsutism: Adrenal Enzyme Defects and Exaggerated Adrenarche*

1986 • 155 citations

EFFECT OF INSULIN-LIKE GROWTH FACTOR-TYPE I (IGF-I) AND INSULIN ON THE SECRETION OF SEX HORMONE BINDING GLOBULIN AND IGF-I BINDING PROTEIN (IBP-I) BY HUMAN HEPATOMA CELLS

1990 • 155 citations

Insulin Resistance andβ-Cell Dysfunction in Aging: The Importance of Dietary Carbohydrate*

1988 • 155 citations

Insulin regulates the 35 kDa IGF binding protein in patients with diabetes mellitus

1988 • 150 citations

EFFECTS OF LUTEINIZING HORMONE, INSULIN, INSULIN‐LIKE GROWTH FACTOR‐I AND INSULINLIKE GROWTH FACTOR SMALL BINDING PROTEIN 1 IN THE POLYCYSTIC OVARY SYNDROME

1990 • 148 citations

Endocrine Determinants of Fertility: Serum Androgen Concentrations during Follow-up of Adolescents into the Third Decade of Life^*

1990 • 146 citations

Relationships between plasma-free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin-dependent diabetic individuals

1987 • 146 citations

Anthropometric Variables and Metabolism in Polycystic Ovarian Disease

1989 • 146 citations

The relationship of cancer of the female breast to artificial menopause and marital status

1956 • 145 citations

Plasma glucose, insulin and lipid responses to high-carbohydrate low-fat diets in normal humans

1983 • 145 citations

Consumption of Olive Oil, Butter, and Vegetable Oils and Coronary Heart Disease Risk Factors

1990 • 144 citations

Correlations Between Fatty Acid and Glucose Metabolism: Potential Explanation of Insulin Resistance of Puberty

1994 • 142 citations

Interrelation between plasma sex hormone-binding globulin and plasma insulin in healthy adult women: the telecom study.

1993 • 142 citations

Lipoprotein lipase activity and intramuscular triglyceride stores after long‐term high‐fat and high‐carbohydrate diets in physically trained men

1987 • 140 citations

Role of insulin receptors in insulin-resistant states

1980 • 138 citations

Habitual Dietary Intake and Glucose Tolerance in Euglycaemic Men: The Zutphen Study

1990 • 138 citations

Changes in Plasma Somatomedin‐C in Response to Ingestion of Diets with Variable Protein and Energy Content

1984 • 135 citations

Benign and Malignant Tumors in Patients With Acromegaly

1991 • 134 citations

Effects of cooking on serum glucose and insulin responses to starch.

1981 • 132 citations

Normative data for insulin-like growth factors (IGFs), IGF-binding proteins, and growth hormone-binding protein in a healthy Spanish pediatric population: age- and sex-related changes.

1993 • 132 citations

Insulin as an Effector of Human Ovarian and Adrenal Steroid Metabolism

1991 • 131 citations

Body fat distribution and steroid hormone concentrations in obese adolescent girls before and after weight reduction.

1995 • 130 citations

Relationship between Insulin, Insulin-Like Growth Factor I, and Dehydroepiandrosterone Sulfate Concentrations During Childhood, Puberty, and Adult Life*

1989 • 130 citations

Coordinate modulation of D-glucose transport activity and bilayer fluidity in plasma membranes derived from control and insulin-treated adipocytes.

1980 • 128 citations

Acromegaly and Colon Cancer

1984 • 126 citations

DIVERGENT CORRELATIONS OF CIRCULATING DEHYDROEPIANDROSTERONE SULFATE AND TESTOSTERONE WITH INSULIN LEVELS AND INSULIN RECEPTOR BINDING.

1988 • 120 citations

Body fat distribution has weight-independent effects on clinical, hormonal, and metabolic features of women with polycystic ovary syndrome

1994 • 120 citations

Strenuous physical activity in young adulthood and risk of breast cancer (United States)

1995 • 120 citations

Body measurements, estrogen availability and the risk of human breast cancer: A case‐control study

1992 • 119 citations

Low levels of low molecular weight insulin-like growth factor-binding protein in patients with polycystic ovarian disease

1989 • 118 citations

The Contributions of Diet and Childbearing to Breast-cancer Rates

1978 • 118 citations

Insulin sensitivity and body fat distribution in normotensive offspring of hypertensive parents

1993 • 116 citations

Insulin resistance in offspring of hypertensive parents.

1993 • 116 citations

Fatty acids, hyperinsulinemia, and insulin resistance: which comes first?

1994 • 115 citations

Mechanism of palmityl coenzyme A inhibition of liver glycogen synthase.

1977 • 114 citations

Energy balance or fat balance?

1993 • 113 citations

Insulin-Like Growth Factor-I Selectively Stimulates Cholesterol Side-Chain Cleavage Expression in Ovarian Theca-lnterstitial Cells

1990 • 113 citations

Glucose Storage Is a Major Determinant of in Vivo “Insulin Resistance” in Subjects with Normal Glucose Tolerance

1986 • 113 citations

Polycystic Ovaries and the Risk of Breast Cancer

1991 • 113 citations

Relationship Between Habitual Physical Activity and Insulin Levels Among Nondiabetic Men and Women: San Luis Valley Diabetes Study

1991 • 113 citations

Serum and urinary androgens and risk of breast cancer in postmenopausal women.

1991 • 112 citations

Diet of second-generation Japanese-American men with and without non-insulin-dependent diabetes

1990 • 112 citations

Puberty and polycystic ovarian syndrome: the insulin/insulin-like growth factor I hypothesis

1992 • 110 citations

Body fat topography in women with androgen excess.

1988 • 109 citations

Sex Hormones and Postmenopausal Breast Cancer: A Prospective Study in an Adult Community

1992 • 108 citations

Insulin secretion and insulin action related to the serum phospholipid fatty acid pattern in healthy men

1989 • 106 citations

Relationship of sex hormone-binding globulin to lipid, lipoprotein, glucose, and insulin concentrations in postmenopausal women

1992 • 106 citations

Associations of abdominal adiposity, fasting insulin, sex hormone binding globulin, and estrone with lipids and lipoproteins in post-menopausal women

1989 • 106 citations

Weight loss is associated with correction of gonadotropin and sex steroid abnormalities in the obese anovulatory female

1984 • 104 citations

Effect of a High Carbohydrate Diet on Insulin Binding to Adipocytes and on Insulin Action in vivo in Man

1979 • 103 citations

Effect of Fish Oil Concentrate on Lipoprotein Composition in NIDDM

1988 • 103 citations

COLON CANCER AND POLYPS IN ACROMEGALY: INCREASED RISK ASSOCIATED WITH FAMILY HISTORY OF COLON CANCER

1990 • 103 citations

Relative contribution of obesity and body fat distribution to alterations in glucose insulin homeostasis: predictive values of selected indices in premenopausal women

1989 • 101 citations

The Influence of Medical Conditions Associated with Hormones on the Risk of Breast Cancer

1993 • 101 citations

Age at Menarche and Breast Cancer<xref ref-type="fn" rid="FN1">2</xref>

1971 • 101 citations

Breast cancer risk and history of selected medical conditions linked with female hormones

1990 • 100 citations

Lower lifetime occurrence of breast cancer and cancers of the reproductive system among former college athletes

1987 • 100 citations

Dietary Fat, Carbohydrate Balance, and Weight Maintenance ^a

1993 • 98 citations

Food quotient, respiratory quotient, and energy balance

1993 • 98 citations

RELATIONSHIP BETWEEN THE PUBERTAL FALL INSEX HORMONE BINDING GLOBULIN AND INSULIN‐LIKE GROWTH FACTOR BINDING PROTEIN‐I. A SYNCHRONIZED APPROACH TO PUBERTAL DEVELOPMENT?

1989 • 97 citations

Colon Polyps in Acromegaly

1991 • 93 citations

Glycaemic index of foods.

1992 • 93 citations

Regulation of sex hormone-binding globulin production by growth factors

1990 • 91 citations

Opposing Actions of Dehydroepiandrosterone and Testosterone on Insulin Sensitivity: In Vivo and In Vitro Studies of Hyperandrogenic Females

1991 • 90 citations

Interrelations between fatty acid oxidation and the control of gluconeogenesis in perfused rat liver

1968 • 90 citations

Regulation of insulin receptors in normal and abnormal physiology in humans.

1979 • 89 citations

BASAL AND STIMULATED INSULIN LEVELS RISE WITH ADVANCING PUBERTY

1988 • 88 citations

Daily physical activity, work capacity and glucose tolerance in lean and obese normoglycaemic middle-aged men

1981 • 88 citations

The effect of year of birth on the breast cancer age‐incidence curve in Iceland

1974 • 87 citations

REVIEW

1991 • 87 citations

Fish Oil in a High Lard Diet Prevents Obesity, Hyperlipemia, and Adipocyte Insulin Resistance in Rats

1993 • 87 citations

Progress in obesity research

1991 • 86 citations

Androgens and breast cancer in premenopausal women.

1989 • 85 citations

The role of adrenal hyperandrogenism, insulin resistance, and obesity in the pathogenesis of polycystic ovarian syndrome.

1993 • 85 citations

Effects of diet on the cellular insulin binding and the insulin sensitivity in young healthy subjects

1978 • 84 citations

Insulin sensitivity in women with polycystic ovary syndrome: relationship to hyperandrogenemia

1994 • 84 citations

Body-fat distribution and changes in the atherogenic risk-factor profile in obese adolescent girls during weight reduction

1994 • 83 citations

Neuro-endocrine disorders seen as triggers of the triad: Obesity-insulin resistance-abnormal glucose tolerance

1985 • 82 citations

Serum sex hormone-binding globulin during puberty in girls and in different types of adolescent menstrual cycles

1984 • 82 citations

Differentiation of ovarian theca-interstitial cells in vitro: regulation of 17 alpha-hydroxylase messenger ribonucleic acid expression by luteinizing hormone and insulin-like growth factor-I.

1993 • 81 citations

The effect of exercise on plasma somatomedin-C/insulinlike growth factor I concentrations

1987 • 81 citations

Twenty-four-hour preoperative endocrine profiles in women with benign and malignant breast disease.

1977 • 81 citations

Insulin and Androgen Relationships with Abdominal Body Fat Distribution in Women with and without Hyperandrogenism

1993 • 80 citations

Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.

1975 • 80 citations

Implications of Birth Cohort Patterns in Interpreting Trends in Breast Cancer Rates

1992 • 79 citations

Insulin Regulation of Insulin-Like Growth Factor-Binding Protein Production in Cultured HepG2 Cells*

1990 • 79 citations

Insulin Receptors and Insulin Resistance

1983 • 77 citations

The relationship of insulin to sex hormone-binding globulin: role of adiposity

1989 • 76 citations

Structural and functional analysis of insulin-like growth factors

1989 • 76 citations

THE EFFECT OF WEIGHT LOSS ON SEX STEROID SECRETION AND BINDING IN MASSIVELY OBESE WOMEN

1981 • 75 citations

Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.

1975 • 75 citations

Implications of ultrasonically diagnosed polycystic ovaries. I. Correlations with basal hormonal profiles

1992 • 74 citations

Gastrointestinal tumors in acromegalic patients.

1985 • 74 citations

Postmenarchal evolution of endocrine pattern and ovarian aspects in adolescents with menstrual irregularities

1987 • 72 citations

Correlation of plasma insulin and insulin‐like growth factor‐I with indices of androgen transport and metabolism in women with polycystic ovary syndrome

1991 • 71 citations

Polycystic ovaries in non-obese and obese patients: possible pathophysiological mechanism based on new interpretation of facts and findings

1993 • 71 citations

DECREASED SEX HORMONE BINDING GLOBULIN (SHBG) AND INSULIN‐LIKE GROWTH FACTOR BINDING PROTEIN (IGFBP‐1) IN EXTREME OBESITY

1990 • 69 citations

Menstrual Irregularities in Adolescents: Hormonal Pattern and Ovarian Morphology

1986 • 68 citations

International differences in body height and weight and their relationship to cancer incidence

1990 • 66 citations

Insulin as a Regulator of Androgen Biosynthesis by Cultured Rat Ovarian Cells: Cellular Mechanism(s) Underlying Physiological and Pharmacological Hormonal Actions*

1988 • 65 citations

Endocrine abnormalities in women with brest cancer.

1955 • 65 citations

Relationship between westernization of dietary habits and mortality from breast and ovarian cancers in Japan.

1987 • 65 citations

Nutrition, body size, and breast cancer

1985 • 64 citations

Cardiovascular Risk Factors in Obese Children in Relation to Weight and Body Fat Distribution

1992 • 64 citations

Insulin‐Like Growth Factor‐I in Human Malnutrition: Relationship with Some Body Composition and Nutritional Parameters

1989 • 62 citations

Relation of serum lipoprotein lipids and apolipoproteins to obesity in children: The Bogalusa heart study

1992 • 62 citations

Androgenicity in relation to body fat distribution and metabolism in 38-year-old women—the European fat distribution study

1990 • 62 citations

Cell membrane fatty acid composition in Type 1 (insulin-dependent) diabetic patients: relationship with sodium transport abnormalities and metabolic control

1993 • 61 citations

The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer

1991 • 61 citations

Steroidal and non-steroidal factors in plasma sex hormone binding globulin regulation

1992 • 61 citations

The Insulin-like growth factors : structure and biological functions

1992 • 60 citations

Correlates of fasting insulin levels in young adults: The cardia study

1991 • 59 citations

An Abnormality of the Growth Hormone/Insulin-Like Growth Factor-I Axis in Women with Polycystic Ovary Syndrome^*

1990 • 58 citations

A discussion of the roles of oestrogen and progestin in human mammary carcinogenesis

1991 • 58 citations

Insulin-Like Growth Factor-I as a Reflection of Body Composition, Nutrition, and Puberty in Sixth and Seventh Grade Girls*

1991 • 58 citations

Body Composition and Regional Fat Distribution in Polycystic Ovarian Syndrome Relationship to Hormonal and Metabolic Profiles

1993 • 57 citations

Epidemiology of Breast Cancer in Japan

1995 • 57 citations

Increased androgenic activity and breast cancer risk in premenopausal women.

1984 • 57 citations

CIRCULATING HORMONE CONCENTRATIONS IN WOMEN WITH BREAST CANCER

1976 • 57 citations

The effect of westernization on urine estrogens, frequency of ovulation, and breast cancer risk. A study of ethnic chinese women in the orient and the USA

1984 • 56 citations

Androgens in breast cancer. I. Atypical endometrial hyperplasia and breast cancer in married premenopausal women

1973 • 56 citations

Obesity and Polycystic Ovary Syndrome^a

1991 • 55 citations

Early polycystic ovary-like syndrome in girls with central precocious puberty and exaggerated adrenal response

1995 • 54 citations

Adipose tissue and reproduction

1991 • 54 citations

Effect of Habitual Physical Activity on Age‐Related Glucose Intolerance

1989 • 53 citations

Androgens and Estrogens in Postmenopausal Insulin-Treated Diabetic Women

1989 • 53 citations

Decreased 34K insulin-like growth factor binding protein in polycystic ovarian disease

1989 • 53 citations

CHANGES IN SERUM INSULIN CONCENTRATION DURING PUBERTY AND THEIR RELATIONSHIP TO GROWTH HORMONE

1988 • 53 citations

Serum Concentrations of Estrone, Androstenedione, Testosterone and Sex-hormone-binding Globulin in Postmenopausal Women with Breast Cancer and in Age-matched Controls

1979 • 51 citations

The role of nutrition and insulin in the regulation of sex hormone binding globulin

1991 • 51 citations

Breast cancer among American Japanese in the San Francisco Bay area.

1977 • 50 citations

Glucose tolerance and hyperinsulinaemia in obese women: role of adipose tissue distribution, muscle fibre characteristics and androgens

1990 • 50 citations

Obesity: an inherited metabolic deficiency in the control of macronutrient balance?

1992 • 48 citations

SERUM SEX HORMONE CONCENTRATIONS IN INSULIN DEPENDENT DIABETIC WOMEN WITH AND WITHOUT AMENORRHOEA

1985 • 48 citations

Fat distribution, androgens, and metabolism in nonobese women

1989 • 48 citations

The insulin-like growth factor binding protein-1 in low and high insulin responders before and during dexamethasone treatment

1991 • 48 citations

Androgens in breast cancer

1974 • 47 citations

Body fat distribution in relation to breast cancer in women participating in the DOM-project

1995 • 47 citations

Exercise, Calories, Fat and Cancer

1992 • 47 citations

Levels of the small insulin-like growth factor-binding protein are strongly related to those of insulin in prepubertal and pubertal children but only weakly so after puberty

1989 • 45 citations

Adipose tissue and reproduction

1990 • 43 citations

Evaluation of Metabolic Effects of Substitution of Complex Carbohydrates for Saturated Fat in Individuals with Obesity and NIDDM

1991 • 43 citations

Twenty-Four-Hour Serum Growth Hormone, Insulin, C-Peptide and Blood Glucose Profiles and Serum Insulin-Like Growth Factor-l Concentrations in Women with Polycystic Ovaries

1992 • 43 citations

Progestins and antiprogestins in mammary tumour growth and metastasis

1994 • 43 citations

Circulating levels of testosterone, 17 β-oestradiol, luteinising hormone and prolactin in postmenopausal breast cancer patients

1983 • 42 citations

Interrelationships between Sex Hormone-Binding Globulin and 17β-Estradiol, Testosterone, 5α-Dihydrotestosterone, Thyroxine, and Triiodothyronine in Prepubertal and Pubertal Girls*

1980 • 41 citations

Environmental and Familial Contributions to Insulin Levels and Change in Insulin Levels in Middle-aged Women

1992 • 41 citations

Androgen excretion in women with a family history of breast cancer or with epithelial hyperplasia or cancer of the breast

1983 • 40 citations

HUMAN GRANULOSA CELLS CONTAIN INSULIN‐LIKE GROWTH FACTOR‐BINDING PROTEIN (IGF BP‐1) mRNA

1990 • 40 citations

Nutritional risk factors for breast cancer

1994 • 39 citations

Androgens in breast cancer

1975 • 39 citations

Consumption of olive oil, butter, and vegetable oils and coronary heart disease risk factors. The Research Group ATS-RF2 of the Italian National Research Council

1990 • 39 citations

INSULIN‐LIKE GROWTH FACTOR BINDING PROTEINS IN FOLLICULAR FLUID FROM NORMAL DOMINANT AND COHORT FOLLICLES, POLYCYSTIC AND MULTICYSTIC OVARIES

1990 • 39 citations

Plasma testosterone and breast cancer

1985 • 38 citations

Responses to protein deficiency of plasma and tissue insulinlike growth factor-I levels and proteoglycan synthesis rates in rat skeletal muscle and bone

1990 • 38 citations

FACTORS ASSOCIATED WITH GLUCOSE TOLERANCE IN ADULTS IN THE UNITED STATES

1987 • 38 citations

High testosterone and low progesterone circulating levels in premenopausal patients with hyperplasia and cancer of the breast.

1984 • 37 citations

Ovarian stromal hyperplasia in breast cancer.

1952 • 37 citations

Reproductive Endocrinology: Physiology, Pathophysiology and Clinical Management

1979 • 37 citations

Altered Insulin Resistance Is Associated with Increased Dietary Weight Loss in Obese Children

1995 • 36 citations

Progressive Increase in Nonsex Hormone-Binding Globulin-Bound Testosterone and Estradiol From Infancy to Late Prepuberty in Girls*

1988 • 36 citations

Non-esterified fatty acids regulate lipid and glucose oxidation and glycogen synthesis in healthy man

1994 • 35 citations

Pubertal Growth and Growth Hormone Secretion

1991 • 34 citations

Insulin-like growth factor I correlations to changes of the hormonal status in puberty and age

2009 • 34 citations

Atherosclerosis precursors in Finnish children and adolescents. VII. Serum immunoreactive insulin

1985 • 33 citations

Dietary Fat, Calories, and Mammary Gland Tumorigenesis

1992 • 32 citations

Familial and environmental influences on body composition and body fat distribution in childhood in southern Italy.

1994 • 31 citations

Insulin, C-peptide, androgens, and beta-endorphin response to oral glucose in patients with polycystic ovary syndrome.

1994 • 30 citations

The Prevention of Breast Cancer through Reduced Ovarian Steroid Exposure

1992 • 30 citations

The Production of Mammary Cancer in Rats Using Oestrogens

1955 • 29 citations

HORMONAL PROFILES IN WOMEN WITH BREAST CANCER

1994 • 29 citations

Simple Versus Complex Carbohydrate Use in the Diabetic Diet

1985 • 29 citations

Relationship between the fatty acid status and insulinemic indexes in obese children

1994 • 28 citations

The role of dietary fiber in the etiology of non-insulin-dependent diabetes mellitus

1993 • 28 citations

Insulin-like growth factor receptors

1992 • 25 citations

INSULIN AND VARIATION IN GLUCOSE LEVELS MODIFY THE SECRETION RATES OF THE GROWTH HORMONE-INDEPENDENT INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-1 IN THE HUMAN HEPATOBLASTOMA CELL LINE HEP G2

1989 • 25 citations

Oncogenes, growth factors and control of the cell cycle.

1993 • 25 citations

OBESITY WITH INSULIN RESISTANCE: EXPERIMENTAL INSIGHTS

1983 • 23 citations

Relationship of growth factors and differentiation in normal and neoplastic development of the mammary gland

1991 • 20 citations

Growth Hormone and Somatomedin-C Secretion in Patients with Polycystic Ovarian Disease

1990 • 20 citations

Prevalence of hypertension and diabetes in breast cancer: a case-control study in 179 patients and age-matched, non-hospitalized controls.

1978 • 18 citations

Hormonal profiles in women with breast cancer (review).

1988 • 17 citations

Insulin-like growth factors as endocrine and paracrine hormones

1992 • 16 citations

89219667 Associations of abdominal adiposity, fasting insulin, sex hormone binding globulin and estrone with lipids and lipoproteins in post-menopausal women

1990 • 16 citations

Mechanisms associating body fat distribution with the abnormal metabolic profile in obesity.

1987 • 13 citations

CHANGES IN ENDOGENOUS INSULIN SECRETION DURING CHILDHOOD AS EXPRESSED BY PLASMA AND URINARY C‐PEPTIDE

1988 • 13 citations

Plasma sex hormone binding globulin concentration and binding capacity in children before and during puberty

1985 • 11 citations

Overnight secretion pattern of growth hormone, sex hormone binding globulin, insulin-like growth factor-1 and its binding protein in obese and non-obese women with polycystic ovarian disease.

1994 • 7 citations

The etiology of polycystic ovary syndrome (PCO)

1989 • 7 citations

The effect of residual beta cell activity on menstruation and the reproductive hormone profile of insulin-dependent diabetics

1989 • 6 citations

The insulin‐like growth factors; structure and biological functions

1992 • 6 citations

Changes In Serum Insulin And Height Velocity During Growth Hormone Therapy Evidence For Down Regulation At Tissue Level

1988 • 5 citations

Glucose tolerance and insulin release in adolescent female

1991 • 5 citations

POLYCYSTIC OVARY SYNDROME

2009 • 4 citations

Population study on the adipose tissue distribution in Japanese women born in 1948

1990 • 3 citations

Deleted Work

1955 • 0 citations