Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1999 • 2,199 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

2004 • 1,877 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

2004 • 1,337 citations

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

1998 • 1,136 citations

Advances in Male Contraception

2008 • 1,127 citations

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

2003 • 1,075 citations

NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates

2005 • 1,057 citations

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

2009 • 1,026 citations

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

2004 • 975 citations

Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes

2001 • 916 citations

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

2010 • 868 citations

Agouti-related peptide–expressing neurons are mandatory for feeding

2005 • 738 citations

Post-prandial decrease of circulating human ghrelin levels

2001 • 691 citations

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

2008 • 679 citations

Orexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related Protein

2004 • 662 citations

Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

2007 • 650 citations

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

1995 • 601 citations

The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

2002 • 594 citations

Studies on the Physiological Functions of the Melanocortin System

2006 • 568 citations

Tissue-specific regulation of SIRT1 by calorie restriction

2008 • 546 citations

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

2008 • 529 citations

Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1

2007 • 526 citations

Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1

2005 • 499 citations

Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage

2005 • 462 citations

Sirt1 contributes critically to the redox-dependent fate of neural progenitors

2008 • 449 citations

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

2006 • 436 citations

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

2009 • 428 citations

Increase in Activity During Calorie Restriction Requires Sirt1

2005 • 426 citations

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

2006 • 399 citations

PI3K integrates the action of insulin and leptin on hypothalamic neurons

2005 • 382 citations

Peripheral ghrelin selectively increases Fos expression in neuropeptide Y – synthesizing neurons in mouse hypothalamic arcuate nucleus

2002 • 330 citations

Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability

2008 • 300 citations

A Central Thermogenic-like Mechanism in Feeding Regulation: An Interplay between Arcuate Nucleus T3 and UCP2

2007 • 279 citations

De NovoNeurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance

2010 • 210 citations

Effects of Hypothalamic Neurodegeneration on Energy Balance

2005 • 208 citations

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

2009 • 193 citations

PI3K integrates the action of insulin and leptin on hypothalamic neurons

2005 • 190 citations

SIR2: a potential target for calorie restriction mimetics

2007 • 186 citations

Plasma Ghrelin Concentration and Energy Balance: Overfeeding and Negative Energy Balance Studies in Twins

2001 • 171 citations

Changes in ghrelin and ghrelin receptor expression according to feeding status

2003 • 164 citations

Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis.

1992 • 159 citations

Exercise-Induced Synaptogenesis in the Hippocampus Is Dependent on UCP2-Regulated Mitochondrial Adaptation

2008 • 155 citations

GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein

2002 • 151 citations

SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice

2007 • 103 citations

Changes in ghrelin and ghrelin receptor expression according to feeding status

2003 • 95 citations

Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis [published erratum appears in Endocrinology 1996 Feb;137(2):532]

1992 • 91 citations

GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein

2002 • 56 citations

Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice

2005 • 51 citations

Plasma Ghrelin Concentration and Energy Balance: Overfeeding and Negative Energy Balance Studies in Twins

2001 • 50 citations

Comparative and pharmacophore model for deacetylase SIRT1

2006 • 48 citations

Transcriptional Regulation of Agouti-Related Protein (Agrp) in Transgenic Mice

2004 • 48 citations

Central oxytocin potentiates excitatory responses of oxytocin neurones to stimulation of the dorsomedial hypothalamic nucleus in the suckled rat

2002 • 46 citations