Heat-shock protein protection

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Proteasome inhibitors: valuable new tools for cell biologists

1998 • 1,453 citations

Viability thresholds and the penumbra of focal ischemia

1994 • 1,358 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1

1998 • 1,198 citations

Heat Shock Transcription Factors: Structure and Regulation

1995 • 1,179 citations

Heme oxygenase 1 is required for mammalian iron reutilization

1997 • 998 citations

Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced Apoptosis

1997 • 961 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury.

1995 • 859 citations

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases

1998 • 692 citations

Oxidative Stress-Induced Actin Reorganization Mediated by the p38 Mitogen-Activated Protein Kinase/Heat Shock Protein 27 Pathway in Vascular Endothelial Cells

1997 • 569 citations

Heat Shock Proteins Increase Resistance to Apoptosis

1996 • 517 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

Influence of molecular and chemical chaperones on protein folding

1996 • 496 citations

Hyperthermia Protects Against Light Damage in the Rat Retina

1988 • 445 citations

The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones.

1997 • 435 citations

Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation.

1996 • 401 citations

The Glucose-Regulated Proteins (GRP78 and GRP94): Functions, Gene Regulation, and Applications

1994 • 391 citations

Small Heat Shock Proteins and Protection Against Ischemic Injury in Cardiac Myocytes

1997 • 345 citations

Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity.

1995 • 343 citations

Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy

1998 • 317 citations

The PCI domain: a common theme in three multiprotein complexes

1998 • 289 citations

The stress protein response in cultured neurons: Characterization and evidence for a protective role in excitotoxicity

1991 • 279 citations

Ischemic tolerance in the brain

1997 • 272 citations

Transient hyperthermia protects against subsequent forebrain ischemic cell damage in the rat

1989 • 270 citations

Cardioprotective effects of 70-kDa heat shock protein in transgenic mice.

1996 • 252 citations

Nitric oxide and carbon monoxide: parallel roles as neural messengers

1998 • 232 citations

Large Unphosphorylated Aggregates as the Active Form of hsp27 Which Controls Intracellular Reactive Oxygen Species and Glutathione Levels and Generates a Protection against TNFα in NIH-3T3-ras Cells

1997 • 221 citations

Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury

1997 • 214 citations

The temporal profile of 72-kDa heat-shock protein expression following global ischemia

1991 • 206 citations

Heat shock proteins functioning as molecular chaperones: their roles in normal and stressed cells

1993 • 200 citations

Expression and function of heat shock protein 47: A collagen-specific molecular chaperone in the endoplasmic reticulum

1998 • 192 citations

Induction of 70-kDa Heat Shock Protein and hsp70 mRNA following Transient Focal Cerebral Ischemia in the Rat

1993 • 187 citations

Cooperative Action of Hsp70, Hsp90, and DnaJ Proteins in Protein Renaturation

1996 • 157 citations

Glucose Transporter Expression in Brain: Relationship to Cerebral Glucose Utilization

1998 • 148 citations

Heme Oxygenase-1 is Induced in Glia Throughout Brain by Subarachnoid Hemoglobin

1998 • 148 citations

Heat-shock proteins and stress tolerance in microorganisms

1992 • 130 citations

Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the ‘penumbra’ following focal cerebral ischemia in the rat

1993 • 126 citations

Defective Herpes Simplex Virus Vectors Expressing the Rat Brain Stress‐Inducible Heat Shock Protein 72 Protect Cultured Neurons from Severe Heat Shock

1997 • 123 citations

The Heat Shock/Stress Response in Focal Cerebral Ischemia

1994 • 114 citations

Heat Shock Proteins hsp90 and hsp70 Protect Neuronal Cells from Thermal Stress but Not from Programmed Cell Death

1994 • 114 citations

Over-expression of heat shock protein 70 protects neuronal cells against both thermal and ischaemic stress but with different efficiencies

1996 • 109 citations

Proteins interacting with the molecular chaperone hsp70/hsc70: physical associations and effects on refolding activity

1997 • 108 citations

Cloning of rat grp75, an hsp70‐family member, and its expression in normal and ischemic brain

1995 • 104 citations

Bcl-2 and Hsp27 act at different levels to suppress programmed cell death

1997 • 96 citations

Identification of invivo substrates of the yeast mitochondrial chaperonins reveals overlapping but non-identical requirement for hsp60 and hsp10

1998 • 96 citations

Overexpression of the Glucose Transporter Gene with a Herpes Simplex Viral Vector Protects Striatal Neurons against Stroke

1996 • 94 citations

Phencyclidine induction of the hsp70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels

1994 • 89 citations

Long‐term Induction of Haem Oxygenase‐1 (HSP‐32) in Astrocytes and Microglia Following Transient Focal Brain Ischaemia in the Rat

1996 • 88 citations

Over-expression of HSP-70 protects astrocytes from combined oxygen-glucose deprivation

1996 • 82 citations

Differential induction of mRNA species encoding several classes of stress proteins following focal cerebral ischemia in rats

1994 • 81 citations

Cortical Application of Potassium Chloride Induces the Low-Molecular Weight Heat Shock Protein (Hsp27) in Astrocytes

1997 • 81 citations

Alpha B-crystallin is associated with intermediate filaments in astrocytoma cells.

1998 • 77 citations

The Hsp70 Homologue Lhs1p Is Involved in a Novel Function of the Yeast Endoplasmic Reticulum, Refolding and Stabilization of Heat-denatured Protein Aggregates

1997 • 73 citations

Hemeoxygenase expression after reversible ischemia of rat brain

1994 • 71 citations

HSP70 protects murine astrocytes from glucose deprivation injury

1997 • 68 citations

Astrocyte survival and HSP70 heat shock protein induction following heat shock and acidosis

1996 • 62 citations

Induction of Heat Shock Protein 70 Protects Thymocytes Against Radiation-Induced Apoptosis

1997 • 58 citations

Astrocyte survival and HSP70 heat shock protein induction following heat shock and acidosis

1996 • 51 citations

Heat shock-induced myocardial protection against ischemic injury: a role for Hsp 70?

1996 • 51 citations

Trigeminal ganglion neurons are protected by the heat shock proteins hsp70 and hsp90 from thermal stress but not from programmed cell death following nerve growth factor withdrawal

1996 • 40 citations

Delivery of a constitutively active form of the heat shock factor using a virus vector protects neuronal cells from thermal or ischaemic stress but not from apoptosis

1998 • 37 citations

Iron Regulation in the Brain at the Cell and Molecular Level

1994 • 33 citations

In vivo activation of neural heat shock transcription factor HSF1 by a physiologically relevant increase in body temperature

1996 • 24 citations

Characterization of the Molecular‐Chaperone Function of the Heat‐Shock‐Cognate‐70–Interacting Protein

1997 • 19 citations

Gene expressions of ubiquitin and hsp70 following focal ischaemia in rat brain

1997 • 11 citations

Preferential Expression of HSC70 Heat Shock mRNA in Gerbil Heart After Transient Brain Ischemia

1993 • 8 citations