Molecular dissection of reactive astrogliosis and glial scar formation

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

2008 • 2,939 citations

Regeneration beyond the glial scar

2004 • 2,896 citations

The Classical Complement Cascade Mediates CNS Synapse Elimination

2007 • 2,812 citations

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

1996 • 2,470 citations

IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel

2005 • 2,138 citations

Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis

2005 • 1,602 citations

Astrocyte activation and reactive gliosis

2005 • 1,513 citations

Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury

2004 • 1,499 citations

Protoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains

2002 • 1,444 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

2005 • 1,433 citations

Pathological and protective roles of glia in chronic pain

2008 • 1,311 citations

New roles for astrocytes: Redefining the functional architecture of the brain

2003 • 1,283 citations

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

2008 • 1,278 citations

Astrocytes are active players in cerebral innate immunity

2007 • 1,225 citations

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

2007 • 1,160 citations

Glial regulation of the cerebral microvasculature

2007 • 1,101 citations

Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

1999 • 1,071 citations

CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity

2001 • 1,024 citations

GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain

2004 • 963 citations

Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury

2006 • 891 citations

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

2008 • 859 citations

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

2008 • 805 citations

An astrocytic basis of epilepsy

2005 • 799 citations

Mechanisms of Disease: astrocytes in neurodegenerative disease

2006 • 790 citations

Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model

2007 • 777 citations

Astrocyte dysfunction in neurological disorders: a molecular perspective

2006 • 776 citations

Activity‐dependent regulation of energy metabolism by astrocytes: An update

2007 • 756 citations

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

2008 • 744 citations

Reactive Astrocytes in Neural Repair and Protection

2005 • 741 citations

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

2003 • 735 citations

Neuronal or Glial Progeny

2003 • 706 citations

Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease

2001 • 655 citations

hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo

2001 • 640 citations

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

2008 • 618 citations

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

2009 • 589 citations

The neurobiology of glia in the context of water and ion homeostasis

2004 • 587 citations

Essential protective roles of reactive astrocytes in traumatic brain injury

2006 • 581 citations

Fulminant Jejuno-Ileitis following Ablation of Enteric Glia in Adult Transgenic Mice

1998 • 572 citations

Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury

2006 • 564 citations

Inhibition of astroglial nuclear factor κB reduces inflammation and improves functional recovery after spinal cord injury

2005 • 542 citations

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

2004 • 530 citations

Protective Role of Reactive Astrocytes in Brain Ischemia

2007 • 486 citations

The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex

2007 • 463 citations

Cx43 Hemichannels and Gap Junction Channels in Astrocytes Are Regulated Oppositely by Proinflammatory Cytokines Released from Activated Microglia

2007 • 450 citations

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

2008 • 441 citations

Astrocyte Influences on Ischemic Neuronal Death

2004 • 435 citations

Absence of Glial Fibrillary Acidic Protein and Vimentin Prevents Hypertrophy of Astrocytic Processes and Improves Post-Traumatic Regeneration

2004 • 433 citations

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

2009 • 431 citations

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

2009 • 430 citations

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

2008 • 341 citations

Ephrin-B2 and EphB2 Regulation of Astrocyte-Meningeal Fibroblast Interactions in Response to Spinal Cord Lesions in Adult Rats

2003 • 332 citations

Astrocyte control of the cerebrovasculature

2007 • 304 citations

Role of Aquaporin-4 in Cerebral Edema and Stroke

2008 • 292 citations

Cytokines: Powerful Regulators of Glial Cell Activation

2003 • 292 citations

Locus Coeruleus α-Adrenergic–Mediated Activation of Cortical Astrocytes In Vivo

2008 • 266 citations

Lipocalin-2 Is an Autocrine Mediator of Reactive Astrocytosis

2009 • 250 citations

Astrocytes Induce Hemeoxygenase-1 Expression in Microglia: A Feasible Mechanism for Preventing Excessive Brain Inflammation

2006 • 247 citations

Transgenic Inhibition of Astroglial NF-κB Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation

2009 • 245 citations

Astrocytes protect neurons from nitric oxide toxicity by a glutathione‐dependent mechanism

2001 • 244 citations

Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem CellsIn Vivo

2006 • 241 citations

P2X7-Like Receptor Activation in Astrocytes Increases Chemokine Monocyte Chemoattractant Protein-1 Expression via Mitogen-Activated Protein Kinase

2001 • 233 citations

Endothelin-1 Regulates Astrocyte Proliferation and Reactive Gliosis via a JNK/c-Jun Signaling Pathway

2008 • 233 citations

Activation of Extracellular Signal-Regulated Kinase by Stretch-Induced Injury in Astrocytes Involves Extracellular ATP and P2 Purinergic Receptors

2003 • 229 citations

Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders

2007 • 228 citations

IL‐1‐regulated responses in astrocytes: Relevance to injury and recovery

2004 • 205 citations

Receptor-mediated glutamate release from volume sensitive channels in astrocytes

2005 • 198 citations

Astrocyte Glycogen Sustains Neuronal Activity during Hypoglycemia: Studies with the Glycogen Phosphorylase Inhibitor CP-316,819 ([R-R*,S*]-5-Chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide)

2007 • 179 citations

A Central Role of Connexin 43 in Hypoxic Preconditioning

2008 • 170 citations

Astrocytes are a specific immunological target in Rasmussen's encephalitis

2007 • 162 citations

Transgenic mice for conditional gene manipulation in astroglial cells

2007 • 151 citations

The Rheb–mTOR Pathway Is Upregulated in Reactive Astrocytes of the Injured Spinal Cord

2009 • 148 citations

Poststroke Neurogenesis: Emerging Principles of Migration and Localization of Immature Neurons

2007 • 148 citations

Astrocyte gp130 Expression Is Critical for the Control of Toxoplasma Encephalitis

2008 • 139 citations

Matrix Metalloproteinase-9 Facilitates Glial Scar Formation in the Injured Spinal Cord

2008 • 137 citations

A new in vitro model of the glial scar inhibits axon growth

2008 • 137 citations

Regulation of glial glutamate transporter expression by growth factors

2003 • 131 citations

Signaling factors in the mechanism of ammonia neurotoxicity

2008 • 131 citations

Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion.

1998 • 129 citations

Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT‐1/EAAT2 subtype

2006 • 125 citations

Transcriptional regulation of scar gene expression in primary astrocytes

2007 • 125 citations

Epileptogenesis and Reduced Inward Rectifier Potassium Current in Tuberous Sclerosis Complex‐1–Deficient Astrocytes

2005 • 125 citations

Expression and Functional Significance of SOCS-1 and SOCS-3 in Astrocytes

2008 • 121 citations

Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)‐regulated glial proliferation

2009 • 119 citations

The Basic Helix-Loop-Helix Transcription Factor Olig2 Is Critical for Reactive Astrocyte Proliferation after Cortical Injury

2008 • 110 citations

Phenotypic and functional heterogeneity of GFAP‐expressing cells in vitro: Differential expression of LeX/CD15 by GFAP‐expressing multipotent neural stem cells and non‐neurogenic astrocytes

2005 • 109 citations

Trophic functions of nucleotides in the central nervous system

2009 • 108 citations

GluR3 Autoantibodies Destroy Neural Cells in a Complement-Dependent Manner Modulated by Complement Regulatory Proteins

2000 • 94 citations

Characterization of astrocyte‐specific conditional knockouts

2007 • 93 citations

Enhancing Glutamate Transport: Mechanism of Action of Parawixin1, a Neuroprotective Compound from Parawixia bistriata Spider Venom

2007 • 81 citations

Adult glial precursor proliferation in mutant SOD1^G93A mice

2007 • 80 citations

Astrocytes Protect Neurons from Ammonia Toxicity

2005 • 76 citations

TGF‐β1 potentiates astrocytic nitric oxide production by expanding the population of astrocytes that express NOS‐2

2006 • 71 citations

IL-6-type cytokines enhance epidermal growth factor-stimulated astrocyte proliferation

2000 • 70 citations

Egr-1 Regulates Expression of the Glial Scar Component Phosphacan in Astrocytes after Experimental Stroke

2008 • 65 citations

Astrocyte failure as a cause of CNS dysfunction

2000 • 47 citations

Molecular Mechanisms of Astrogliosis

2007 • 45 citations

CPEB1 regulates β‐catenin mRNA translation and cell migration in astrocytes

2008 • 38 citations

Expression profiling identifies a molecular signature of reactive astrocytes stimulated by cyclic AMP or proinflammatory cytokines

2007 • 36 citations