Zn²⁺ entry produces oxidative neuronal necrosis in cortical cell cultures

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

1979 • 27,693 citations

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

1996 • 1,057 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons

1987 • 852 citations

A novel neuronal messenger molecule in brain: The free radical, nitric oxide

1992 • 837 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

Ischemia-induced neuronal apoptosis

1996 • 600 citations

Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II)

1993 • 490 citations

New aspects in the biological role of zinc: A stabilizer of macromolecules and biological membranes

1973 • 387 citations

Potentiated Necrosis of Cultured Cortical Neurons by Neurotrophins

1995 • 360 citations

Hepatic Glutathione Reductase

1962 • 353 citations

The cell-death machine

1996 • 351 citations

Translocation of zinc may contribute to seizure-induced death of neurons

1989 • 347 citations

Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons

1990 • 302 citations

AMPA receptor activation potentiates zinc neurotoxicity

1993 • 280 citations

Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro

1995 • 258 citations

Staurosporine-Induced Neuronal Apoptosis

1995 • 248 citations

Zinc neurotoxicity in cortical cell culture

1988 • 244 citations

Zinc-Containing Neurons

1994 • 224 citations

Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-d-aspartate receptors

1994 • 223 citations

Chelation of intracellular zinc triggers apoptosis in mature thymocytes.

1993 • 180 citations

The influence of zinc on apoptosis.

1995 • 176 citations

Slowly triggered excitotoxicity occurs by necrosis in cortical cultures

1997 • 175 citations

Zinc has opposite effects on NMDA and Non-NMDA receptors expressed in xenopus oocytes

1990 • 165 citations

Glutamate‐Induced Neuronal Death Is Not a Programmed Cell Death in Cerebellar Culture

1993 • 160 citations

The mechanism of the insulin-like effects of ionic zinc.

1982 • 156 citations

Caspase Inhibition Selectively Reduces the Apoptotic Component of Oxygen-Glucose Deprivation-Induced Cortical Neuronal Cell Death

1997 • 151 citations

Characterization of Zinc-Induced Neuronal Death in Primary Cultures of Rat Cerebellar Granule Cells

1997 • 142 citations

NMDA and Kainate Induce Internucleosomal DNA Cleavage Associated With Both Apoptotic and Necrotic Cell Death in the Neonatal Rat Brain

1995 • 130 citations

Inhibition of free radical production or free radical scavenging protects from the excitotoxic cell death mediated by glutamate in cultures of cerebellar granule neurons

1996 • 121 citations

Inhibition of glutathione peroxidase by cadmium and other metal ions

1979 • 99 citations

Glutamate stably enhances the activity of two cytosolic forms of phospholipase A2 in brain cortical cultures

1995 • 95 citations

Preferential induction of apoptosis in mouse CD4⁺CD8⁺αβTCR^IoCD3ε^Io thymocytes by zinc

1995 • 80 citations

BDNF or IGF-I potentiates free radical-mediated injury in cortical cell cultures.

1995 • 73 citations

Glutamate neurotoxicity in mouse cortical neurons: atypical necrosis with DNA ladders and chromatin condensation

1998 • 72 citations

Kainate induces apoptosis in neurons

1996 • 67 citations

BDNF or IGF-I potentiates free radical-mediated injury in cortical cell cultures

1995 • 64 citations

Quantitative multiwell myeloid differentiation assay using dichlorodihydrofluorescein diacetate (H2DCF-DA) or dihydrorhodamine 123 (H2R123)

1995 • 58 citations

Attenuation of Oxidative Neuronal Necrosis by a Dopamine D1 Agonist in Mouse Cortical Cell Cultures

1997 • 54 citations

Glutamate Neurotoxicity, Calcium, and Zinc^a

1989 • 51 citations

Internucleosomal cleavage of DNA as the sole criterion for apoptosis may be artifactual.

1994 • 48 citations

Antioxidant-dependent amelioration of brain injury: role of CuZn-superoxide dismutase.

1992 • 48 citations

ICE-like proteases execute the neuronal death program

1996 • 42 citations

Nerve growth factor potentiates the oxidative necrosis of striatal cholinergic neurons

1998 • 23 citations

Absence of mutations in peripheral myelin protein-22, myelin protein zero, and connexin 32 in autosomal recessive Dejerine-Sottas syndrome

1998 • 15 citations

Augmentation of endotoxin hepatotoxicity by zinc

1993 • 5 citations