How do neurons die in neurodegenerative diseases?

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

1991 • 3,275 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Oxidative Stress Hypothesis in Alzheimer's Disease

1997 • 2,355 citations

Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

1997 • 2,184 citations

A Drosophila model of Parkinson's disease

2000 • 2,062 citations

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

2000 • 1,975 citations

Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions

1998 • 1,592 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

1997 • 1,395 citations

Induction of Midbrain Dopaminergic Neurons from ES Cells by Stromal Cell–Derived Inducing Activity

2000 • 1,267 citations

Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease

2000 • 1,063 citations

Trinucleotide repeat length instability and age of onset in Huntington's disease

1993 • 1,062 citations

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1997 • 1,016 citations

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

1996 • 956 citations

The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease

1998 • 845 citations

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

2000 • 722 citations

Tau protein pathology in neurodegenerative diseases

1998 • 674 citations

Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis

1998 • 663 citations

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

1990 • 630 citations

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

1987 • 602 citations

Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene

1997 • 549 citations

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

2000 • 520 citations

Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson's Disease Mutation

1998 • 510 citations

Neurodegenerative Diseases

1994 • 492 citations

Oxidative Stress in Huntington's Disease

1999 • 491 citations

Energetics in the pathogenesis of neurodegenerative diseases

2000 • 479 citations

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

2000 • 400 citations

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

1993 • 379 citations

Fine Structural Observations of Neurofilamentous Changes in Amyotrophic Lateral Sclerosis

1984 • 355 citations

Advanced glycation endproducts in ageing and Alzheimer's disease

1997 • 267 citations

Transplanted fetal striatum in Huntington's disease: Phenotypic development and lack of pathology

2000 • 259 citations

Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis

1999 • 194 citations

E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.

1996 • 132 citations

Quantitative study on dendrites and dendritic spines in Alzheimer's disease and senile dementia.

1975 • 129 citations

Cerebral amyloidosis, ageing and Alzheimer's disease; A contribution from studies on Down's syndrome

1989 • 112 citations

Oxidative stress: its role in the pathogenesis of amyotrophic lateral sclerosis

1995 • 75 citations

Parkinsonsche Krankheit (Paralysis agitans) und postencephalitischer Parkinsonismus

1940 • 74 citations

Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease

1993 • 71 citations

Ubiquitin in Motor Neuron Disease

1991 • 68 citations

Nuclear membrane indentations in Huntington's chorea

1983 • 52 citations

Parkinson disease gene therapy moves toward the clinic

2000 • 48 citations

Changes in shapes of surviving motor neurons in amyotrophic lateral sclerosis

1993 • 43 citations

The nervous system and aging.

1980 • 15 citations

Deleted Work

1955 • 0 citations