FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

1998 • 586 citations

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

1995 • 306 citations

A NOVEL IMMUNOSUPPRESSANT, FTY720, WITH A UNIQUE MECHANISM OF ACTION, INDUCES LONG-TERM GRAFT ACCEPTANCE IN RAT AND DOG ALLOTRANSPLANTATION1

1996 • 291 citations

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. II. FTY720 Prolongs Skin Allograft Survival by Decreasing T Cell Infiltration into Grafts But Not Cytokine Production In Vivo

1998 • 263 citations

Immunosuppressants: Cellular and molecular mechanisms of action

1996 • 148 citations

Potent Immunosuppressants, 2-Alkyl-2-aminopropane-1,3-diols

1996 • 134 citations

FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats.

1996 • 127 citations

Simple compounds, 2-alkyl-2-amino-1,3-propanediols have potent immunosuppressive activity

1995 • 102 citations

IMMUNOSUPPRESSIVE EFFECTS OF FTY720 ALONE OR IN COMBINATION WITH CYCLOSPORINE AND/OR SIROLIMUS1

1998 • 101 citations

The identification of myriocin-binding proteins

1999 • 94 citations

FTY720, a New Immunosuppressant, Promotes Long-Term Graft Survival and Inhibits the Progression of Graft Coronary Artery Disease in a Murine Model of Cardiac Transplantation

1999 • 81 citations

PROPHYLAXIS OF ACUTE RENAL ALLOGRAFT REJECTION USING FTY720 IN COMBINATION WITH SUBTHERAPEUTIC DOSES OF CYCLOSPORINE1

1999 • 73 citations

FTY720, a novel immunosuppressant possessing unique mechanisms. II. Long-term graft survival induction in rat heterotopic cardiac allografts and synergistic effect in combination with cyclosporine A.

1996 • 71 citations

The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720

1997 • 68 citations

Differential Activation of c-Jun NH2-Terminal Kinase and p38 Pathways During FTY720-Induced Apoptosis of T Lymphocytes That Is Suppressed by the Extracellular Signal-Regulated Kinase Pathway

1999 • 61 citations

Prevention of graft rejection and graft-versus-host reaction by a novel immunosuppressant, FTY 720, in rat small bowel transplantation

1997 • 50 citations

FTY720, a novel immunosuppressant possessing unique mechanisms. III. Synergistic prolongation of canine renal allograft survival in combination with cyclosporine A.

1996 • 49 citations

Immunosuppressive effect of a new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats

1996 • 48 citations

FTY720: a new immunosuppressive agent with novel mechanism(s) of action

1998 • 39 citations

Synergistic interaction of FTY720 with cyclosporine or sirolimus to prolong heart allograft survival

1998 • 37 citations

Induction of Tolerance Toward Rat Cardiac Allografts by Treatment With Allochimeric Class I MHC Antigen And FTY7201

1997 • 32 citations

FTY720, a novel immunosuppressive agent, enhances upregulation of the cell adhesion molecular ICAM-1 in TNF-a treated human umbilical vein endothelial cells

1997 • 26 citations

2-Substituted 2-aminoethanol: Minimum essential structure for immunosuppressive activity of ISP-I (Myriocin)

1995 • 20 citations

FTY720 compares with FK 506 as rescue therapy in rat heterotopic cardiac transplantation

1998 • 20 citations

Prevention of Experimentally Induced Autoimmune Type I Diabetes in Rats by the New Immunosuppressive Reagent FTY720

1998 • 19 citations

Effect of peritransplant FTY720 alone or in combination with posttransplant FK 506 in a rat model of cardiac allotransplantation

1997 • 11 citations

HUMAN SAFETY AND PHARMACOLOGY OF FTY 720

1999 • 11 citations

HUMAN PHARMACOKINETICS OF FTY 720

1999 • 10 citations

FTY 720 SUPPRESSES IMMUNE RESPONSES BY MODULATING G-PROTEIN COUPLED RECEPTORS ON LYMPHOCYTES RESULTING IN ALTERED LYMPHOCYTE HOMING

1999 • 5 citations

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