Reprogramming of a melanoma genome by nuclear transplantation

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

Viable offspring derived from fetal and adult mammalian cells

1997 • 4,774 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Epigenetics in human disease and prospects for epigenetic therapy

2004 • 3,142 citations

Circular binary segmentation for the analysis of array-based DNA copy number data

2004 • 2,261 citations

Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

1998 • 2,257 citations

Chromatin modification and epigenetic reprogramming in mammalian development

2002 • 1,870 citations

Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

2001 • 1,672 citations

Applying the principles of stem-cell biology to cancer

2003 • 1,623 citations

Induction of Tumors in Mice by Genomic Hypomethylation

2003 • 1,479 citations

Genome-wide analysis of DNA copy-number changes using cDNA microarrays

1999 • 1,445 citations

Rules for Making Human Tumor Cells

2002 • 928 citations

Essential role for oncogenic Ras in tumour maintenance

1999 • 880 citations

Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor

2002 • 792 citations

Nuclear Cloning and Epigenetic Reprogramming of the Genome

2001 • 767 citations

A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G ₀ Cells

2002 • 748 citations

Evidence of a Pluripotent Human Embryonic Stem Cell Line Derived from a Cloned Blastocyst

2004 • 729 citations

Epidermal growth factor receptor and Ink4a/Arf

2002 • 647 citations

Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

2002 • 639 citations

Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation

2001 • 621 citations

Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy

2002 • 612 citations

Therapeutic implications of cancer stem cells

2003 • 562 citations

Monoclonal mice generated by nuclear transfer from mature B and T donor cells

2002 • 529 citations

Cancer revoked: oncogenes as therapeutic targets

2003 • 479 citations

Representational Oligonucleotide Microarray Analysis: A High-Resolution Method to Detect Genome Copy Number Variation

2003 • 452 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

Mice cloned from olfactory sensory neurons

2004 • 379 citations

MYC recruits the TIP60 histone acetyltransferase complex to chromatin

2003 • 379 citations

Chromosomal position and activation of retroviral genomes inserted into the germ line of mice

1981 • 344 citations

Mouse cloning with nucleus donor cells of different age and type

2001 • 337 citations

Nuclear Transplantation, Embryonic Stem Cells, and the Potential for Cell Therapy

2003 • 321 citations

The genetics of malignant melanoma: lessons from mouse and man

2003 • 289 citations

Role of DNA 5-Methylcytosine Transferase in Cell Transformation by fos

1999 • 237 citations

Development of Spontaneous Mammary Tumors in BALB/c p53 Heterozygous Mice

2000 • 185 citations

Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission

1997 • 184 citations

Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression

2003 • 181 citations

Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes

2001 • 168 citations

Transplantation of Pluripotential Nuclei from Triploid Frog Tumors

1969 • 160 citations

Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis

2002 • 159 citations

High-Resolution Global Profiling of Genomic Alterations with Long Oligonucleotide Microarray

2004 • 153 citations

Mouse embryos cloned from brain tumors.

2003 • 139 citations

Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation

2002 • 138 citations

Generation of completely embryonic stem cell-derived mutant mice using tetraploid blastocyst injection

1997 • 128 citations

Nuclear transplantation: lessons from frogs and mice

2002 • 121 citations

Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice

2000 • 119 citations

Allelotype of pediatric rhabdomyosarcoma

1997 • 103 citations

WWOX, the common chromosomal fragile site, FRA16D, cancer gene

2003 • 83 citations

All-trans retinoic acid in acute promyelocytic leukaemia

2003 • 79 citations

X Chromosome-Linked Transmission and Expression of Retroviral Genomes Microinjected into Mouse Zygotes

1983 • 32 citations

Embryonal tumors from transgenic mouse zygotes carrying human activated c-Ha-ras genes.

1989 • 13 citations

Fate of herpesvirus DNA in embryos and tadpoles cloned from Lucké renal carcinoma nuclei

1994 • 13 citations