Nuclear transplantation: lessons from frogs and mice

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

Viable offspring derived from fetal and adult mammalian cells

1997 • 4,774 citations

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

2000 • 3,564 citations

Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

1998 • 3,360 citations

Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

1998 • 2,257 citations

Stem Cells

2000 • 1,783 citations

Completion of mouse embryogenesis requires both the maternal and paternal genomes

1984 • 1,529 citations

Cloned pigs produced by nuclear transfer from adult somatic cells

2000 • 1,243 citations

Transplantation of living nuclei from blastula cells into enucleated frogs’ eggs

1952 • 1,095 citations

Eight Calves Cloned from Somatic Cells of a Single Adult

1998 • 1,062 citations

Production of goats by somatic cell nuclear transfer

1999 • 1,007 citations

Large offspring syndrome in cattle and sheep

1998 • 875 citations

Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells

2001 • 874 citations

Pig Cloning by Microinjection of Fetal Fibroblast Nuclei

2000 • 842 citations

Nuclear Cloning and Epigenetic Reprogramming of the Genome

2001 • 767 citations

Epigenetic Instability in ES Cells and Cloned Mice

2001 • 713 citations

Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation

2001 • 621 citations

Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy

2002 • 612 citations

Cloned rabbits produced by nuclear transfer from adult somatic cells

2002 • 565 citations

Differentiation of Embryonic Stem Cell Lines Generated from Adult Somatic Cells by Nuclear Transfer

2001 • 560 citations

A cat cloned by nuclear transplantation

2002 • 546 citations

Monoclonal mice generated by nuclear transfer from mature B and T donor cells

2002 • 529 citations

Oct4 distribution and level in mouse clones: consequences for pluripotency

2002 • 520 citations

Evidence for Placental Abnormality as the Major Cause of Mortality in First-Trimester Somatic Cell Cloned Bovine Fetuses1

2000 • 505 citations

Mice cloned from embryonic stem cells

1999 • 482 citations

Cloning of male mice from adult tail-tip cells

1999 • 474 citations

Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells

2000 • 471 citations

Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells

1997 • 469 citations

Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei

2002 • 416 citations

Cloned mice have an obese phenotype not transmitted to their offspring

2002 • 363 citations

Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei

2000 • 359 citations

Generation of mice from wild-type and targeted ES cells by nuclear cloning

2000 • 348 citations

Mouse cloning with nucleus donor cells of different age and type

2001 • 337 citations

Generation of histocompatible tissues using nuclear transplantation

2002 • 336 citations

Aberrant patterns of X chromosome inactivation in bovine clones

2002 • 328 citations

Chromosomal variation in neurons of the developing and adult mammalian nervous system

2001 • 327 citations

“Fertile” Intestine Nuclei

1966 • 280 citations

Faithful Expression of Imprinted Genes in Cloned Mice

2002 • 274 citations

Early death of mice cloned from somatic cells

2002 • 274 citations

The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs

1975 • 273 citations

X-Chromosome Inactivation in Cloned Mouse Embryos

2000 • 270 citations

Mammalian cloning: advances and limitations

2000 • 250 citations

The health profile of cloned animals

2002 • 247 citations

Cloned zebrafish by nuclear transfer from long-term-cultured cells

2002 • 246 citations

Reprogramming fibroblasts to express T-cell functions using cell extracts

2002 • 243 citations

Placentomegaly in Cloned Mouse Concepti Caused by Expansion of the Spongiotrophoblast Layer1

2001 • 231 citations

Cloning of mice to six generations

2000 • 228 citations

Cloned Cattle Can Be Healthy and Normal

2001 • 184 citations

Normal telomere lengths found in cloned cattle

2000 • 184 citations

Birth of Mice after Transplantation of Early Cell-Cycle-Stage Embryonic Nuclei into Enucleated Oocytes1

1993 • 184 citations

Changes in the nuclei of differentiating endoderm cells as revealed by nuclear transplantation

1957 • 169 citations

Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle

2001 • 159 citations

Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation

2002 • 138 citations

Abnormal Expression of Trophoblast Major Histocompatibility Complex Class I Antigens in Cloned Bovine Pregnancies Is Associated with a Pronounced Endometrial Lymphocytic Response1

2002 • 134 citations

Mouse embryonic stem (ES) cell lines established from neuronal cell-derived cloned blastocysts

2000 • 116 citations

Assessment of the developmental totipotency of neural cells in the cerebral cortex of mouse embryo by nuclear transfer

2001 • 101 citations

Genetic Stability and Modulation of Metazoan Nuclei Transplanted into Eggs and Oocytes

1980 • 80 citations

Reprogrammed gene expression in a somatic cell‐free extract

2002 • 76 citations

Odorant receptor gene regulation: implications from genomic organization

2002 • 67 citations

Full-term development after transfer of nuclei from 4-cell and compacted morula stage embryos to enucleated oocytes in the mouse

1997 • 58 citations

Lymphocytes of the Toad Xenopus laevis Have the Gene Set for Promoting Tadpole Development

1975 • 56 citations

Comparison of intracytoplasmic sperm injection for inbred and hybrid mice

2001 • 55 citations

Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle

2001 • 54 citations

Development and cellular differentiation of neural nuclear-transplants of known karyotype

1967 • 54 citations

Feeding tadpoles cloned from Rana erythrocyte nuclei.

1986 • 53 citations

INTRASPECIFIC NUCLEAR TRANSPLANTATION IN FROGS

1962 • 52 citations

From intestine to muscle: Nuclear reprogramming through defective cloned embryos

2002 • 46 citations