Generation of completely embryonic stem cell-derived mutant mice using tetraploid blastocyst injection

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1988 • 2,004 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

1986 • 1,118 citations

Bone and haematopoietic defects in mice lacking c-fos

1992 • 939 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

Embryonic stem cells alone are able to support fetal development in the mouse

1990 • 789 citations

An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo

1989 • 596 citations

Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.

1994 • 593 citations

A Novel ES Cell Line, TT2, with High Germline-Differentiating Potency

1993 • 475 citations

Regulation of embryonic growth and lysosomal targeting by the imprintedIgf2/Mpr gene

1994 • 471 citations

[51] Gene targeting in embryonic stem cells

1993 • 320 citations

Non-injection methods for the production of embryonic stem cell-embryo chimaeras

1993 • 286 citations

Altering mice by homologous recombination using embryonic stem cells.

1994 • 211 citations

A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras.

1991 • 172 citations

Electrofusion of mouse blastomeres

1985 • 162 citations

Production of completely ES cell-derived fetuses.

1993 • 132 citations

Postimplantation development of tetraploid mouse embryos produced by electrofusion

1990 • 108 citations

Restricted Distribution of Tetraploid Cells in Mouse Tetraploid ↔ Diploid Chimaeras

1995 • 105 citations

A chimaeric animal model for confined placental mosaicism

1994 • 61 citations

Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver.

1991 • 52 citations

Production of Mice Entirely Derived from Embryonic Stem (ES) Cell with Many Passages by Coculture of ES Cells with Cytochalasin B Induced Tetraploid Embryos.

1995 • 36 citations

Electrofusion of mouse embryos results in uniform tetraploidy and not tetraploid/diploid mosaicism

1992 • 25 citations

The identification of new genes: Gene trapping in transgenic mice

1993 • 18 citations

Exogenous Mtv-7 superantigen transgene expression in major histocompatibility complex class II I-E- mice reconstituted with embryonic stem cell-derived hematopoietic stem cells.

1994 • 8 citations