mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

1981 • 509 citations

Gene conversion: Some implications for immunoglobulin genes

1981 • 496 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes

1981 • 314 citations

Origin of Antibody Variation

1966 • 314 citations

Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangments in heavy chain V-region gene segments

1980 • 272 citations

Complete sequence of constant and 3′ noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing

1978 • 211 citations

Evolution of immunoglobulin V genes: Evidence indicating that recently duplicated human Vκ sequences have diverged by gene conversion

1983 • 165 citations

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

1981 • 161 citations

The joining of V and J gene segments creates antibody diversity

1980 • 137 citations

Two kappa immunoglobulin genes are expressed in the myeloma S107

1981 • 117 citations

Experimental Immunology

1989 • 117 citations

Inheritance of antibody specificity V. Anti-2-phenyloxazolone in the mouse.

1978 • 116 citations

Anti-oxazolone hybridomas and the structure of the oxazolone idiotype.

1983 • 114 citations

Organization and evolution of immunoglobulin VH gene subgroups.

1982 • 114 citations

Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity.

1981 • 109 citations

The genetic basis of antibody production: The dominant anti‐arsonate idiotype response of the strain a mouse

1982 • 100 citations

Allelic forms of rat κ chain genes: Evidence for strong selection at the level of nucleotide sequence

1981 • 76 citations

The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse.

1982 • 76 citations

Structural studies on induced antibodies with defined idiotypic specificities. IX. Framework differences in the heavy- and light-chain-variable regions of monoclonal anti-p-azophenylarsonate antibodies from A/J mice differing with respect to a cross-reactive idiotype.

1980 • 73 citations

Nucleotide sequence of immunoglobulin heavy chain joining segments between translocated VH and mu constant regions genes.

1980 • 69 citations

Polymorphism in anti-phosphocholine antibodies reflecting evolution of immunoglobulin families.

1983 • 63 citations

Analysis of antibody diversity: V-D-J mRNA nucleotide sequence of four anti-GAT monoclonal antibodies. A paucigene system using alternate D-J recombinations to generate functionally similar hypervariable regions.

1983 • 59 citations

Complete amino acid sequence of light chain variable regions derived from five monoclonal anti-p-azophenylarsonate antibodies differing with respect to a crossreactive idiotype.

1981 • 56 citations

The limited diversity of the mouse gamma-chains anti-GAT repertoire does not seem to be noticeably amplified upon class switch.

1982 • 13 citations

Erythro-immunoassay using phytohaemagglutinin ⪡ phaseolosaxin ⪢

1981 • 9 citations

An immunoglobulin V gene polymorphism in the rat

1982 • 4 citations