Lck Domains Differentially Contribute to Pre–T Cell Receptor (Tcr)–And TCR-α/β–Regulated Developmental Transitions

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Selective Events in T Cell Development

1994 • 486 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

1997 • 362 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

1996 • 324 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

1992 • 254 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains.

1994 • 235 citations

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

1988 • 232 citations

The Src family of tyrosine protein kinases in hemopoietic signal transduction

1992 • 221 citations

The Influence of the MAPK Pathway on T Cell Lineage Commitment

1997 • 217 citations

Fyn Can Partially Substitute for Lck in T Lymphocyte Development

1996 • 213 citations

The MAP Kinase Pathway Controls Differentiation from Double-Negative to Double-Positive Thymocyte

1996 • 213 citations

p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain.

1992 • 212 citations

Expression and function of CD4 in a murine T-cell hybridoma

1987 • 208 citations

Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

1992 • 181 citations

Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

1989 • 174 citations

Thymic tumorigenesis induced by overexpression of p56lck.

1991 • 172 citations

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1997 • 159 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

Involvement of p21^ras activation in T cell CD69 expression

1994 • 154 citations

Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.

1993 • 144 citations

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor β-chain genes

1993 • 130 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

Developmental regulation of lck gene expression in T lymphocytes.

1991 • 124 citations

Delayed thymocyte development induced by augmented expression of p56lck.

1991 • 117 citations

Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα

1997 • 106 citations

Acquisition of transforming properties by FYN, a normal SRC-related human gene.

1988 • 87 citations

Structure of the Murine lck Gene and Its Rearrangement in a Murine Lymphoma Cell Line

1988 • 86 citations

Activation of the Extracellular Signal-Related Kinase/Mitogen-Activated Protein Kinase Pathway Discriminates CD4 Versus CD8 Lineage Commitment in the Thymus

1999 • 86 citations

A signaling pathway governing early thymocyte maturation

1995 • 76 citations

Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines.

1995 • 72 citations

Neoplastic Transformation Induced by an Activated Lymphocyte-Specific Protein Tyrosine Kinase (pp56^lck)

1988 • 66 citations

Two lck Transcripts Containing Different 5′ Untranslated Regions are Present in T Cells

1987 • 63 citations

The Src SH3 Domain Is Required for DNA Synthesis Induced by Platelet-derived Growth Factor and Epidermal Growth Factor

1996 • 62 citations

TCR engagement of CD4+CD8+ thymocytes in vitro induces early aspects of positive selection, but not apoptosis.

1997 • 62 citations

CD3 Ligation on Immature Thymocytes Generates Antagonist-like Signals Appropriate for CD8 Lineage Commitment, Independently of T Cell Receptor Specificity

1998 • 59 citations

p59^fyn Tyrosine Kinase Associates with Multiple T-Cell Receptor Subunits through Its Unique Amino-Terminal Domain

1992 • 58 citations

The Lck SH3 Domain Is Required for Activation of the Mitogen-activated Protein Kinase Pathway but Not the Initiation of T-cell Antigen Receptor Signaling

1999 • 57 citations

Identification of Src, Fyn, and Lyn SH3-Binding Proteins: Implications for a Function of SH3 Domains

1994 • 56 citations

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes

1995 • 52 citations

Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line.

1988 • 43 citations

Oncogenic activation of p59fyn tyrosine protein kinase by mutation of its carboxyl-terminal site of tyrosine phosphorylation, tyrosine 528.

1994 • 43 citations

Unique Catalytic Properties Dictate the Enhanced Function of p59^fynT, the Hemopoietic Cell-Specific Isoform of the Fyn Tyrosine Protein Kinase, in T cells

1994 • 34 citations

SH2 domains of the protein-tyrosine kinases Blk, Lyn, and Fyn(T) bind distinct sets of phosphoproteins from B lymphocytes.

1993 • 33 citations

p56lck Signals for Regulating Thymocyte Development Can Be Distinguished by Their Dependency on Rho Function

1998 • 33 citations

The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected]

1993 • 31 citations

Two lck transcripts containing different 5' untranslated regions are present in T cells.

1987 • 31 citations

Unique catalytic properties dictate the enhanced function of p59fynT, the hemopoietic cell-specific isoform of the Fyn tyrosine protein kinase, in T cells.

1994 • 25 citations

Targets of p56(lck) activity in immature thymoblasts: stimulation of the Ras/Raf/MAPK pathway

1997 • 23 citations

Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes.

1993 • 22 citations

Disease specificity of kinase domains: the src-encoded catalytic domain converts erbB into a sarcoma oncogene.

1995 • 4 citations

Detection of Transgene lntegrants and Homologous Recombinants in Mice by Polymerase Chain Reaction

2003 • 3 citations