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The Molecular Pathogenesis of Hereditary and Sporadic Adrenocortical and Adrenomedullary Tumors

Data up to Jan 2025

Published2002
Citations182
References219

Total Citations Per Year

Abstract

References (219)

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Adrenocortical Tumors*

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ACTH induces up-regulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines

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SMALL ADENOMAS OF THE ADRENAL CORTEX IN HYPERTENSION AND DIABETES

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Adrenocortical carcinoma is characterized by a high frequency of chromosomal gains and high-level amplifications

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Loss of NF1 alleles in phaeochromocytomas from patients with type 1 neurofibromatosis

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Adrenal Involvement in Multiple Endocrine Neoplasia Type 1

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p53 Mutations in sporadic adrenocortical tumors

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Adrenal medullary hyperplasia. A morphometric analysis in patients with familial medullary thyroid carcinoma.

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C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B

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Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas.

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Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction—primer-introduced restriction analysis

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RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours

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Comparative Genomic Hybridization Analysis of Adrenocortical Tumors

2002 • 136 citations

Genetic events in tumour initiation and progression in multiple endocrine neoplasia type 2

1993 • 134 citations

Clonal composition of human adrenocortical neoplasms.

1994 • 133 citations

Prognostic markers in pheochromocytoma

1998 • 129 citations

Comparative Genomic Hybridization Analysis of Adrenocortical Tumors of Childhood1

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Genotyping of Adrenocortical Tumors: Very Frequent Deletions of the MEN1 Locus in 11q13 and of a 1-Centimorgan Region in 2p161

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Consistent association of 1p loss of heterozygosity with pheochromocytomas from patients with multiple endocrine neoplasia type 2 syndromes.

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p53 mutations in human adrenocortical neoplasms: immunohistochemical and molecular studies

1994 • 117 citations

Mutations of the p53 gene in human functional adrenal neoplasms.

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Comparative Genomic Hybridization Reveals Frequent Losses of Chromosomes 1p and 3q in Pheochromocytomas and Abdominal Paragangliomas, Suggesting a Common Genetic Etiology

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Losses of Chromosomes 1p and 3q Are Early Genetic Events in the Development of Sporadic Pheochromocytomas

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Clonal analysis of human adrenocortical carcinomas and secreting adenomas

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Plasma Renin Activity in Primary Aldosteronism

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Bilateral adrenal medullary hyperplasia in multiple endocrine neoplasia, type 2: the precursor of bilateral pheochromocytoma.

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Analysis of Genomic Alterations in Sporadic Adrenocortical Lesions

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No evidence for oncogenic mutations in the adrenocorticotropin receptor gene in human adrenocortical neoplasms.

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Immunohistochemical expression of epidermal growth factor receptors in human adrenocortical carcinoma

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Duplication of the mutant RET allele in trisomy 10 or loss of the wild-type allele in multiple endocrine neoplasia type 2-associated pheochromocytomas.

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Diagnosis, localization, and management of pheochromocytoma pitfalls and follow-up in 41 patients

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MEN1 Gene mutation analysis of sporadic adrenocortical lesions

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Molecular definition of the 11p15.5 region involved in Beckwith-Wiedemann syndrome and probably in predisposition to adrenocortical carcinoma

1989 • 97 citations

Deletion of the Adrenocorticotropin Receptor Gene in Human Adrenocortical Tumors: Implications for Tumorigenesis1

1997 • 96 citations

Molecular analysis of CDKN1C and TP53 in sporadic adrenal tumors

2001 • 95 citations

MEN1Gene Analysis in Sporadic Adrenocortical Neoplasms1

1999 • 95 citations

Differential Genetic Alterations in von Hippel-Lindau Syndrome-Associated and Sporadic Pheochromocytomas1

2000 • 95 citations

Clinical Implications of Genetic Defects in G Proteins

1999 • 93 citations

Limitations of size as a criterion in the evaluation of adrenal tumors

2000 • 93 citations

Differences between sporadic pheochromocytoma and pheochromocytoma in multiple endocrine neoplasia, type 2

1980 • 92 citations

Comparative Genomic Hybridization Analysis of Adrenocortical Tumors of Childhood

1999 • 92 citations

Detection of Novel Germ-line p53 Mutations in Diverse-Cancer-Prone Families Identifiled by Selecting Patients With Childhood Adrencortical Carcinoma

1992 • 92 citations

Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia type 1 (MEN1): loss of heterozygosity for polymorphic chromosome 11 deoxyribonucleic acid markers, including the MEN1 locus.

1992 • 89 citations

Familial hyperaldosteronism

2001 • 88 citations

Discerning malignancy in adrenocortical tumors: are molecular markers useful?

2001 • 88 citations

Germline mutations in thevhl gene in patients presenting with phaeochromocytomas

1998 • 88 citations

Cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex).

1996 • 86 citations

Pheochromocytoma in von Hippel-Lindau Disease: Distinct Histopathologic Phenotype Compared to Pheochromocytoma in Multiple Endocrine Neoplasia Type 2

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Clonal Origin of Inherited Medullary Thyroid Carcinoma and Pheochromocytoma

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Multiple Endocrine Neoplasia, Type 2B

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Bilateral occurrence of pheochromocytoma in patients with the multiple endocrine neoplasia syndrome type 2A (Sipple's syndrome)

1981 • 78 citations

Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization

1999 • 78 citations

Are activating mutations of the adrenocorticotropin receptor involved in adrenal cortical neoplasia?

1995 • 77 citations

Activating mutation in the stimulatory guanine nucleotide-binding protein in an infant with Cushing's syndrome and nodular adrenal hyperplasia.

1994 • 77 citations

Loss of neurofibromin in adrenal gland tumors from patients with neurofibromatosis type I

1994 • 76 citations

Hyperplasia versus adenoma in endocrine tissues: are they different?

2002 • 74 citations

Prognostic value of p53, bcl-2, and c-erbB-2 protein expression in phaeochromocytomas

1999 • 73 citations

Deletion of the Adrenocorticotropin Receptor Gene in Human Adrenocortical Tumors: Implications for Tumorigenesis

1997 • 71 citations

Sporadic and familial pheochromocytomas are associated with loss of at least two discrete intervals on chromosome 1p.

2000 • 71 citations

Ribonucleic Acid Expression of the Clustered Imprinted Genes, p57KIP2, Insulin-Like Growth Factor II, and H19, in Adrenal Tumors and Cultured Adrenal Cells1

1997 • 69 citations

MEN1 Gene Analysis in Sporadic Adrenocortical Neoplasms

1999 • 67 citations

Familial Pheochromocytoma, Hypercalcemia, and Von Hippel-Lindau Disease

1979 • 67 citations

Differential Genetic Alterations in von Hippel-Lindau Syndrome-Associated and Sporadic Pheochromocytomas

2000 • 66 citations

A Case of Neonatal McCune‐Albright Syndrome with Cushing Syndrome and Hyperthyroidism

1991 • 65 citations

Loss of heterozygosity on the short arm of chromosomes 1 and 3 in sporadic pheochromocytoma and extra-adrenal paraganglioma

1997 • 64 citations

Elevated levels of telomerase activity in malignant pheochromocytoma

1998 • 63 citations

The RET protooncogene in sporadic pheochromocytomas: frequent MEN 2-like mutations and new molecular defects.

1995 • 63 citations

Familial Cushing's syndrome with primary adrenocortical microadenomatosis (primary adrenocortical nodular dysplasia)

1980 • 60 citations

Divergent differentiation in neuroendocrine tumors of the adrenal gland.

2000 • 60 citations

Sporadic phaeochromocytomas are rarely associated with germline mutations in the von Hippel‐Lindau and RET genes

1997 • 60 citations

Loss of neurofibromatosis type I (NFI) gene expression in pheochromocytomas from patients without NFI

1995 • 59 citations

High Expression of Cyclin E and G1 CDK and Loss of Function of p57KIP2Are Involved in Proliferation of Malignant Sporadic Adrenocortical Tumors1

2000 • 59 citations

Mutations in the RET protooncogene in sporadic pheochromocytomas.

1995 • 57 citations

No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms.

1993 • 56 citations

Clonality as Expression of Distinctive Cell Kinetics Patterns in Nodular Hyperplasias and Adenomas of the Adrenal Cortex

2000 • 56 citations

Loss of heterozygosity on the short arm of chromosome 3 in sporadic, von hippel‐lindau disease‐associated, and familial pheochromocytoma

1995 • 53 citations

Steroid 21-Hydroxylase Mutations and 21-Hydroxylase Messenger Ribonucleic Acid Expression in Human Adrenocortical Tumors1

1998 • 53 citations

Allelic losses on chromosome band 11q13 in aldosterone‐producing adrenal tumors

1995 • 52 citations

Selective loss of chromosome 11 in pheochromocytomas associated with the VHL syndrome

2002 • 52 citations

Biological characteristics of adrenocortical carcinoma: a study of p53, IGF, EGF-r, Ki-67 and PCNA in 17 adrenocortical carcinomas.

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Mutations of K-ras oncogene in human adrenal tumours in Taiwan

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Adrenal medullary hyperplasia.

1978 • 50 citations

Allelic imbalance of the mutant and wild-type RET allele in MEN 2A-associated medullary thyroid carcinoma

2001 • 49 citations

Transforming growth factor alpha, epidermal growth factor, and epidermal growth factor receptor expression in normal and diseased human adrenal cortex by immunohistochemistry and in situ hybridization.

1994 • 49 citations

Commentary on incidence of primary aldosteronism: current estimations based on objective data.

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p53 mutations in adrenal tumors: Caucasian patients do not show the exon 4 "hot spot" found in Taiwan.

1996 • 46 citations

Absent Ras Gene Mutations in Human Adrenal Cortical Neoplasms and Pheochromocytomas

1993 • 46 citations

Angiotensin II type 1 receptor and ACTH receptor expression in human adrenocortical neoplasms

2001 • 45 citations

Prognostic value ofRET proto-oncogene point mutations in malignant and benign, sporadic phaeochromocytomas

1998 • 45 citations

Absence ofTP53 alterations in pheochromocytomas and medullary thyroid carcinomas

1997 • 44 citations

Telomerase activity as an indicator of potentially malignant adrenal tumors

1998 • 44 citations

Somatic Mutations of the Angiotensin II (AT1) Receptor Gene are Not Present in Aldosterone-Producing Adenoma1

1997 • 44 citations

Point mutations of ras genes in human adrenal cortical tumors: Absence in adrenocortical hyperplasia

1994 • 44 citations

High Expression of Cyclin E and G1 CDK and Loss of Function of p57KIP2 Are Involved in Proliferation of Malignant Sporadic Adrenocortical Tumors

2000 • 44 citations

The relatively high frequency of p53 gene mutations in multiple and malignant phaeochromocytomas

1998 • 41 citations

Regulation of Ras signaling by the cell cycle

2002 • 39 citations

The role of the insulin‐like growth factor system in adrenocortical tumourigenesis

2000 • 38 citations

Loss of Heterozygosity on Chromosomes 1p and 11p in Sporadic Pheochromocytoma

1989 • 38 citations

Telomerase Activity Is Significantly Enhanced in Malignant Adrenocortical Tumors in Comparison to Benign Adrenocortical Adenomas

2000 • 37 citations

Somatic Mutations of the Angiotensin II (AT1) Receptor Gene are Not Present in Aldosterone-Producing Adenoma

1997 • 36 citations

Survivin: a novel neuroendocrine marker for pheochromocytoma

2002 • 35 citations

Presence of a Gsα mutation in an adrenal tumor expressing LH/hCG receptors and clinically associated with Cushing's syndrome

2000 • 35 citations

Somatic VHL gene deletion and point mutation in MEN 2A-associated pheochromocytoma

2002 • 35 citations

Oncogenic mutations of α-Gi2 protein are not determinant for human adrenocortical tumourigenesis

1995 • 34 citations

No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms

1993 • 34 citations

Three-Decade Investigation of Familial Pheochromocytoma

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p53 mutations in adrenal tumors: Caucasian patients do not show the exon 4 "hot spot" found in Taiwan

1996 • 33 citations

Gene Expression and Roles of Angiotensin II Type 1 and Type 2 Receptors in Human Adrenals

1998 • 33 citations

Clonal patterns in phaeochromocytomas and MEN-2A adrenal medullary hyperplasias: histological and kinetic correlates

2000 • 31 citations

A comparative study of 14 cases of familial and nonfamilial pheochromocytomas

1978 • 31 citations

Commentary on Incidence of Primary Aldosteronism

1969 • 29 citations

Inactivation of the p16 Tumor Suppressor Gene in Adrenocortical Tumors1

1999 • 29 citations

Telomerase activity in benign and malignant adrenal tumors

2009 • 28 citations

Mutation Analysis of Gs.ALPHA., Adrenocorticotropin Receptor and p53 Genes in Japanese Patients with Adrenocortical Neoplasms. Including a Case of Gs.ALPHA. Mutation.

2000 • 28 citations

Expression and prognostic value of c‐erbB‐2 oncogene product in human phaeochromocytomas

1997 • 28 citations

Molecular and Structural Analysis of Two Novel STAR Mutations in Patients with Lipoid Congenital Adrenal Hyperplasia

2001 • 27 citations

Mapping the Human Melanocortin 2 Receptor (Adrenocorticotropic Hormone Receptor; ACTHR) Gene (MC2R) to the Small Arm of Chromosome 18 (18p11.21-pter)

1993 • 27 citations

No overrepresentation of congenital adrenal hyperplasia in patients with adrenocortical tumours

1999 • 27 citations

Steroid 21-Hydroxylase Mutations and 21-Hydroxylase Messenger Ribonucleic Acid Expression in Human Adrenocortical Tumors

1998 • 25 citations

Monoclonality of endocrine tumours: what does it mean?

2001 • 24 citations

Reassignment of the EPB4·1 gene to 1p36 and assessment of its involvement in neuroblastomas

2001 • 23 citations

Absence of angiotensin II type 1 receptor gene mutations in human adrenal tumors

1997 • 23 citations

VIRILIZING ADRENAL ADENOMA IN AN ADULT WITH THE BECKWITH‐WIEDEMANN SYNDROME: PARADOXICAL RESPONSE TO DEXAMETHASONE

1989 • 23 citations

Inactivation of the p16 Tumor Suppressor Gene in Adrenocortical Tumors

1999 • 23 citations

Multiple endocrine neoplasia type 2A

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Deletion analysis of the p16 tumour suppressor gene in phaeochromocytomas

1996 • 22 citations

Successful laparoscopic operation of bilateral pheochromocytoma in a patient with Beckwith-Wiedemann syndrome

2002 • 22 citations

Telomerase activity in adrenal cortical tumors and pheochromocytomas with reference to clinicopathologic features

1998 • 21 citations

MEN I gene mutations in sporadic adrenal adenomas

1999 • 20 citations

Expression of c-fosand c-mycProto-Oncogenes in Human Adrenal Pheochromocytomas*

1990 • 20 citations

Beckwith-Wiedemann syndrome and virilizing cortical adrenal tumor in a child

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Primäre pigmentierte noduläre adrenokortikale Dysplasie (PPNAD) im Rahmen des Carney-Komplexes als Ursache eines Cushing-Syndroms

2000 • 19 citations

Telomerase activity in the differentiation of benign and malignant adrenal tumors

1998 • 18 citations

Genetics of the development and function of the adrenal cortex.

2001 • 17 citations

Adrenal Medullary Hyperplasia

2018 • 16 citations

DIFFERENT ALLELIC PATTERNS AT CHROMOSOME 11q13 IN PAIRED ALDOSTERONE-PRODUCING TUMOURS AND BLOOD DNA

1996 • 16 citations

Somatic mutations of the RET proto-oncogene are not required for tumor development in multiple endocrine neoplasia type 2 (MEN 2) gene carriers.

1996 • 14 citations

Mutation analysis of the c-mos proto-oncogene and the endothelin-B receptor gene in medullary thyroid carcinoma and phaeochromocytoma

1996 • 14 citations

Complete Sequencing and mRNA Expression Analysis of the MEN-I Gene in Adrenal Myelolipoma

2000 • 13 citations

THE EFFECT OF PHYSICAL EXERCISE ON THE WEDGED AND FREE HEPATIC VENOUS PRESSURE IN NORMAL MEN

1973 • 12 citations

Adrenal ganglioneuroma

1996 • 11 citations

Multiple Endocrine Neoplasia Type 2B

2005 • 11 citations

P53 protein and its messenger ribonucleic acid in human adrenal tumors

1998 • 9 citations

[Genetics of endocrine diseases].

1979 • 9 citations

Calcium-dependent protein kinase-C activity in human adrenocortical neoplasms, hyperplastic adrenals, and normal adrenocortical tissue.

1994 • 9 citations

[112 cases of sporadic and genetically determined pheochromocytoma: a comparative pathologic study].

1999 • 7 citations

Alterations of RET, Oncogene in Human Adrenal Tumors

1998 • 6 citations

Loss of neurofibromatosis type 1 (NF1) gene expression in pheochromocytomas from patients without NF1

1994 • 6 citations

Deleted Work

1955 • 0 citations

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