Molecular and Genetic Mechanisms of Tumorigenesis in Multiple Endocrine Neoplasia Type-1

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1

1997 • 2,009 citations

Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma

1988 • 1,022 citations

Genetic aspects of adenomatosis of endocrine glands

1954 • 850 citations

Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription

1999 • 611 citations

Determinants of metastatic rate and survival in patients with zollinger-ellison syndrome: A prospective long-term study

1995 • 474 citations

Clinical studies of multiple endocrine neoplasia type 1 (MEN1)

1996 • 460 citations

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

2001 • 453 citations

Characterization of Mutations in Patients with Multiple Endocrine Neoplasia Type 1

1998 • 436 citations

FAMILIAL MULTIPLE ENDOCRINE ADENOMA-PEPTIC ULCER COMPLEX

1964 • 432 citations

Menin, the product of the MEN1 gene, is a nuclear protein

1998 • 426 citations

Somatic mutation of the MEN1 gene in parathyroid tumours

1997 • 403 citations

Gastrinomas in the Duodenums of Patients with Multiple Endocrine Neoplasia Type 1 and the Zollinger-Ellison Syndrome

1990 • 387 citations

Association of Parathyroid Tumors in Multiple Endocrine Neoplasia Type 1 with Loss of Alleles on Chromosome 11

1989 • 336 citations

Smads bind directly to the Jun family of AP-1 transcription factors

1999 • 324 citations

Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras

1994 • 313 citations

Multiple Facial Angiofibromas and Collagenomas in Patients With Multiple Endocrine Neoplasia Type 1

1997 • 303 citations

Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors.

1990 • 296 citations

Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.

1997 • 293 citations

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling

2001 • 291 citations

JunD Protects Cells from p53-Dependent Senescence and Apoptosis

2000 • 257 citations

Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung

1997 • 248 citations

The tumor suppressor protein menin interacts with NF-κB proteins and inhibits NF-κB-mediated transactivation

2001 • 247 citations

Mutations of the MEN1 tumor suppressor gene in pituitary tumors.

1997 • 241 citations

Multiple Endocrine Neoplasia Type 1: A 10-Year Prospective Screening Study in Four Kindreds*

1991 • 235 citations

Clinical and genetic features of adrenocortical lesions in multiple endocrine neoplasia type 1.

1992 • 224 citations

Germ-Line Mutation Analysis in Patients with Multiple Endocrine Neoplasia Type 1 and Related Disorders

1998 • 210 citations

Mutations and Allelic Deletions of the MEN1 Gene Are Associated with a Subset of Sporadic Endocrine Pancreatic and Neuroendocrine Tumors and Not Restricted to Foregut Neoplasms

1999 • 210 citations

The variable penetrance and spectrum of manifestations of multiple endocrine neoplasia type 1

1998 • 186 citations

Surgical pathology of gastrinoma. Site, size, multicentricity, association with multiple endocrine neoplasia type 1, and malignancy

1991 • 179 citations

Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias.

1999 • 176 citations

Prognostic factors in patients with Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1

1999 • 169 citations

Alterations of theMEN1Gene in Sporadic Parathyroid Tumors1

1998 • 166 citations

Mutation Analysis of theMEN1Gene in Multiple Endocrine Neoplasia Type 1, Familial Acromegaly and Familial Isolated Hyperparathyroidism¹

1998 • 162 citations

The Natural History of Multiple Endocrine Neoplasia Type 1

1991 • 161 citations

Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors.

1997 • 158 citations

The multiple endocrine neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids

1997 • 158 citations

Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density.

1996 • 157 citations

Parathyroid MEN1 Gene Mutations in Relation to Clinical Characteristics of Nonfamilial Primary Hyperparathyroidism1

1998 • 145 citations

Characterization of the mouse Men1 gene and its expression during development

1998 • 137 citations

Mutation of the MENIN gene in sporadic pancreatic endocrine tumors.

1998 • 136 citations

Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients.

1996 • 133 citations

Familial Isolated Hyperparathyroidism Maps to the Hyperparathyroidism-Jaw Tumor Locus in 1q21-q32 in a Subset of Families¹

1998 • 126 citations

Common ancestral mutations in theMEN1 gene is likely responsible for the prolactinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland

1998 • 120 citations

Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism

1999 • 118 citations

Expression of the MEN‐1 gene in a large kindred with multiple endocrine neoplasia type 1

1998 • 115 citations

Molecular Characterization of the Men1 Tumor Suppressor Gene in Sporadic Pituitary Tumors

1998 • 115 citations

Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1.

1991 • 113 citations

Localization of the genetic defect in multiple endocrine neoplasia type 1 within a small region of chromosome 11.

1989 • 112 citations

Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas.

1998 • 111 citations

Multiple Endocrine Neoplasia Type I

1986 • 109 citations

Adrenal Lesions in a Large Kindred With Multiple Endocrine Neoplasia Type 1

1996 • 108 citations

Allelic loss from chromosome 11 in parathyroid tumors.

1992 • 108 citations

Stable overexpression of MEN1 suppresses tumorigenicity of RAS

1999 • 105 citations

Absence of Germ-Line Mutations of the Multiple Endocrine Neoplasia Type 1 (MEN1) Gene in Familial Pituitary Adenoma in Contrast to MEN1 in Japanese1

1998 • 104 citations

Genotype/Phenotype Correlation of Multiple Endocrine Neoplasia Type 1 Gene Mutations in Sporadic Gastrinomas

2000 • 102 citations

MEN1 Gene mutation analysis of sporadic adrenocortical lesions

1999 • 98 citations

Cutaneous Tumors in Patients with Multiple Endocrine Neoplasia Type 1 Show Allelic Deletion of the MEN1 Gene

1998 • 96 citations

Analysis of Loss of Heterozygosity on Chromosome 11 and Infrequent Inactivation of the MEN1 Gene in Sporadic Pituitary Adenomas1

1998 • 94 citations

Familial Isolated Hyperparathyroidism as a Variant of Multiple Endocrine Neoplasia Type 1 in a Large Danish Pedigree¹

2000 • 93 citations

Clinical features of multiple endocrine neoplasia type 1 (MEN1) phenocopy without germline MEN1 gene mutations: analysis of 20 Japanese sporadic cases with MEN1

2000 • 93 citations

Somatic mutations of multiple endocrine neoplasia type 1 gene in the sporadic endocrine tumors.

1998 • 84 citations

Thymic carcinoids in multiple endocrine neoplasia type 1

1998 • 83 citations

Germline mutations in the multiple endocrine neoplasia type 1 gene: Evidence for frequent splicing defects

1999 • 81 citations

Expression analysis of endogenous menin, the product of the multiple endocrine neoplasia type 1 gene, in cell lines and human tissues

2000 • 79 citations

Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1).

1996 • 79 citations

Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13

1998 • 76 citations

Cell cycle regulation of menin expression.

1999 • 72 citations

Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene

1999 • 71 citations

Screening for MEN1 mutations in patients with atypical endocrine neoplasia

1999 • 70 citations

Results of Treatment of Pituitary Disease in Multiple Endocrine Neoplasia, Type I

1996 • 70 citations

Loss of heterozygosity of markers on chromosome 11 in tumors from patients with multiple endocrine neoplasia syndrome type 1.

1990 • 70 citations

Prolactinomas in a large kindred with multiple endocrine neoplasia type 1: clinical features and inheritance pattern.

1996 • 68 citations

Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.

1997 • 68 citations

A Large Germline Deletion of the MEN1 Gene in a Family with Multiple Endocrine Neoplasia Type 1

1998 • 67 citations

Lack of MEN1 gene mutations in 27 sporadic insulinomas

2000 • 67 citations

Linkage analysis of multiple endocrine neoplasia type 1 with INT2 and other markers on chromosome 11

1989 • 67 citations

Sequence analysis and transcript expression of the MEN1 gene in sporadic pituitary tumours

1999 • 63 citations

Nuclear/cytoplasmic localization of the multiple endocrine neoplasia type 1 gene product, menin.

1999 • 63 citations

Mapping the gene for hereditary hyperparathyroidism and prolactinoma (MEN1Burin) to chromosome 11q: evidence for a founder effect in patients from Newfoundland.

1994 • 59 citations

Detailed physical map of human chromosomal region 11q12-13 shows high meiotic recombination rate around the MEN1 locus.

1991 • 57 citations

Menin mutations in patients with multiple endocrine neoplasia type 1

1997 • 54 citations

Loss of heterozygosity on chromosome 11 in sporadic gastrinomas

1992 • 53 citations

Chromosome abnormalities in lymphocytes and fibroblasts of subjects with multiple endocrine neoplasia type 1

1991 • 53 citations

Germline MEN1 mutations in sixteen Japanese families with multiple endocrine neoplasia type 1 (MEN1)

1999 • 51 citations

Identification of five novel germline mutations of the MEN1 gene in Japanese multiple endocrine neoplasia type 1 (MEN1) families.

1998 • 50 citations

Multiple endocrine neoplasia type 1 (MEN1) gene mutations in a subset of patients with sporadic and familial primary hyperparathyroidism target the coding sequence but spare the promoter region

2000 • 50 citations

Germline and somatic mutation of the gene for multiple endocrine neoplasia type 1 (MEN1)

1998 • 49 citations

MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1

2000 • 49 citations

MEN1 gene mutations in 12 MEN1 families and their associated tumors

1998 • 49 citations

Frequency of somatic MEN1 gene mutations in monoclonal parathyroid tumours of patients with primary hyperparathyroidism

2000 • 49 citations

Novel V184EMEN1 germline mutation in a Japanese kindred with familial hyperparathyroidism

1998 • 48 citations

The Origin of Sporadic Gastrinomas Within the Gastrinoma Triangle

1998 • 47 citations

Proliferation-Associated Expression of the MEN1 Gene as Revealed by In Situ Hybridization: Possible Role of the Menin as a Negative Regulator of Cell Proliferation Under DNA Damage

2000 • 47 citations

Fine-scale mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN 1).

1992 • 43 citations

MEN1 gene mutations in sporadic neuroendocrine tumors of foregut derivation

1999 • 41 citations

Analysis of recurrent germline mutations in theMEN1 gene encountered in apparently unrelated families

1998 • 41 citations

Mutations of the MEN1 tumor suppressor gene in sporadic pituitary tumors

1999 • 40 citations

Isolation, characterization, expression and functional analysis of the zebrafish ortholog of MEN1

2000 • 40 citations

Novel MEN1 gene mutations in familial multiple endocrine neoplasia type 1

1998 • 40 citations

Premature Centromere Division in Patients with Multiple Endocrine Neoplasia Type 1

1999 • 38 citations

Parathyroid hyperplasia in multiple endocrine neoplasia type 1: a pathological and immunohistochemical reappraisal

1992 • 35 citations

Primary structure, gene expression and chromosomal mapping of rodent homologs of the MEN1 tumor suppressor gene

1999 • 34 citations

Structure and distribution of rat menin mRNA

1999 • 34 citations

A novel mutation of the MEN1 gene in a Japanese kindred with familial isolated primary hyperparathyroidism

2000 • 33 citations

Characterization of the MEN1 Ortholog in Zebrafish

1999 • 32 citations

Complementary DNA structure and genomic organization of Drosophila menin

2000 • 31 citations

Different Phenotypes of Multiple Endocrine Neoplasia Type 1 (MEN1) in Monozygotic Twins Found in a Japanese MEN1 Family with MEN1 Gene Mutation.

2000 • 30 citations

Chromosomal instability in multiple endocrine neoplasia type 1 cytogenetic evaluation with DEB test

1995 • 30 citations

Screening for MEN1 tumor suppressor gene mutations in sporadic pituitary tumors

2000 • 29 citations

Multiple endocrine neoplasia type 1 in France: clinical and genetic studies

1995 • 26 citations

Identification of MEN1 Mutations in Sporadic Enteropancreatic Neuroendocrine Tumors by Analysis of Paraffin-embedded Tissue

1999 • 24 citations

Nonidentical Expressions of Multiple Endocrine Neoplasia, Type I, in Identical Twins

1986 • 23 citations

Parathyroid carcinoma in a patient with non-secretory pituitary tumor: a variant of multiple endocrine neoplasia type-I?

1992 • 22 citations

A novel splicing mutation (894-9 G→A) of the MEN1 gene responsible for multiple endocrine neoplasia type 1

1999 • 21 citations

A new mutation of the MEN1 gene in an italian kindred with multiple endocrine neoplasia type 1

1999 • 20 citations

Multiple Endocrine Neoplasia Type 1 Presented with Manic-Depressive Disorder: A Case Report with an Identified MEN1 Gene Mutation

1997 • 20 citations

Type 1 multiple endocrine neoplasia (MEN1): contribution of genetic analysis to the screening and follow‐up of a large French kindred

1999 • 18 citations

Multiple endocrine neoplasia type 1 (MEN1): clinical heterogeneity in a large family with a nonsense mutation in the MEN1 gene (Trp471Stop)

1999 • 14 citations

Loss of Genetic Information in Cancer

2007 • 11 citations

A novel germline mutation in exon 5 of the multiple endocrine neoplasia type 1 gene

1998 • 11 citations

Somatic mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in patients with sporadic, nonfamilial primary hyperparathyroidism

2000 • 10 citations

Clonal Analysis by Chromosome 11 Microsatellite-PCR of Microdissected Parathyroid Tumors from MEN 1 Patients

1996 • 10 citations

Molecular Pathology of Multiple Endocrine Neoplasia Type I

1999 • 9 citations

A Novel Germline Mutation of Multiple Endocrine Neoplasia Type 1 (MEN1) Gene in a Japanese MEN1 Patient and Her Daughter.

1999 • 7 citations

Pancreatic endocrine tumors with loss of heterozygosity at the multiple endocrine neoplasia type I locus

1997 • 7 citations

Sublocalization of the multiple endocrine neoplasia type 1 gene.

1992 • 3 citations