Is inhibition of cyclooxygenase required for the chemopreventive effect of NSAIDs in colon cancer? A model reconciling the current contradiction

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

1996 • 1,987 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

1994 • 820 citations

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

1997 • 734 citations

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

1996 • 613 citations

Altered eicosanoid levels in human colon cancer.

1993 • 571 citations

Inhibition of apoptosis during development of colorectal cancer.

1995 • 548 citations

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.

1996 • 462 citations

Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors

1996 • 438 citations

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

1995 • 433 citations

Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.

1996 • 421 citations

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.

1995 • 420 citations

Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.

1997 • 369 citations

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

1997 • 362 citations

Nonsteroidal Antiinflammatory Drugs Inhibit the Proliferation of Colon Adenocarcinoma Cells: Effects on Cell Cycle and Apoptosis

1996 • 343 citations

Prostaglandin H synthases, nonsteroidal antiinflammatory drugs, and colon cancer

1997 • 290 citations

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

1995 • 253 citations

Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts.

1995 • 210 citations

Prostaglandins from tumours of human large bowel

1977 • 202 citations

Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo

1995 • 196 citations

Chemical and Biological Studies on Indomethacin, Sulindac and their Analogs

1977 • 196 citations

Nonsteroidal anti-inflammatory drugs and colorectal cancer: Evolving concepts of their chemopreventive actions

1997 • 178 citations

Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines.

1996 • 173 citations

The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins.

1996 • 151 citations

Effect of aspirin on induction of apoptosis in HT-29 human colon adenocarcinoma cells

1998 • 134 citations

The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells

1996 • 131 citations

Rectal proliferation and polyp occurrence in patients with familial adenomatous polyposis after sulindac treatment

1994 • 130 citations

Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis.

1998 • 127 citations

Complete reversion and prevention of rectal adenomas in colectomized patients with familial adenomatous polyposis by rectal low-dose sulindac maintenance treatment

1995 • 117 citations

Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis.

1998 • 104 citations

Clinical and genomic influence of sulindac on rectal mucosa in familial adenomatous polyposis

1997 • 76 citations

Sulindac sulfide inhibits the proliferation of colon cancer cells: diminished expression of the proliferation markers PCNA and Ki-67

1997 • 52 citations

Tissue prostaglandin levels in familial adenomatous polyposis patients treated with sulindac

1996 • 43 citations

Local immunity and metastasis of colorectal carcinoma

1992 • 31 citations

Sulindac sulfide alters the expression of cyclin proteins in HT-29 colon adenocarcinoma cells

1998 • 29 citations

Sulindac sulfide induces several subpopulations of colon cancer cells, defined by PCNA/Ki-67 and DNA strand breaks

1997 • 13 citations