Chemical and Biological Studies on Indomethacin, Sulindac and their Analogs

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

1909 • 6,516 citations

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

1962 • 5,670 citations

Arzneimittelforschung

2012 • 3,595 citations

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Pharmacological Reviews

2024 • 2,716 citations

Drug Metabolism and Disposition

2014 • 2,466 citations

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

1971 • 1,535 citations

The Journal of Laboratory and Clinical Medicine

2003 • 1,534 citations

Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine

1971 • 1,433 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Drugs which inhibit prostaglandin biosynthesis.

1974 • 1,325 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

Danish Medical Bulletin

1990 • 1,191 citations

Tables for Convenient Calculation of Median-Effective Dose (LD 50 or ED 50 ) and Instructions in Their Use

1952 • 1,061 citations

Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

1974 • 1,004 citations

Acetylation of prostaglandin synthase by aspirin.

1975 • 1,003 citations

Indomethacin and Aspirin abolish Prostaglandin Release from the Spleen

1971 • 940 citations

American Journal of Hospital Pharmacy

1958 • 874 citations

Biphasic development of carrageenin edema in rats.

1969 • 778 citations

Molecular Pharmacology

1965 • 715 citations

Fortschritte der Arzneimittelforschung

1960 • 669 citations

Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

1973 • 640 citations

THE AMERICAN REVIEW OF RESPIRATORY DISEASES

1965 • 611 citations

Prostaglandins

1975 • 520 citations

Closure of the Ductus Arteriosus in Premature Infants by Inhibition of Prostaglandin Synthesis

1976 • 505 citations

Investigative Ophthalmology

1961 • 501 citations

Prostaglandin Endoperoxides. A New Concept Concerning the Mode of Action and Release of Prostaglandins

1974 • 495 citations

Effects of Anti-inflammatory Drugs on Prostaglandin Biosynthesis

1972 • 478 citations

Utilization of operational schemes for analog synthesis in drug design

1972 • 435 citations

New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory Drugs

1974 • 427 citations

ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDOMETHACIN, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID.

1963 • 406 citations

Obstetrics and Gynecology

2022 • 401 citations

Prostaglandin Synthetase Inhibitors

1977 • 394 citations

On the Metabolism of Prostaglandins E1 and E2 in Man

1971 • 384 citations

A Study of the Factors Involved in the Production of Gastric Ulcers by the Restraint Technique

1960 • 371 citations

Molecular Pharmacology

1971 • 339 citations

Screens for anti-inflammatory drugs

1971 • 332 citations

STUDIES ON THE ABSORPTION, DISTRIBUTION AND EXCRETION OF INDOMETHACIN IN VARIOUS SPECIES

1966 • 318 citations

Prostaglandins and the mechanism of analgesia produced by aspirin‐like drugs

1973 • 296 citations

Prostaglandins, peptides and amines,

1969 • 295 citations

Small intestinal ulcers and intestinal flora in rats given indomethacin.

1969 • 293 citations

Prostaglandin Synthetase Inhibitors I

1979 • 279 citations

Zur Frage des Mechanismus der Hemmung des Bindegewebswachstums durch Cortisone

1950 • 277 citations

Effect of Alterations in Side Chain upon Anti-inflammatory and Liver Glycogen Activities of Hydrocortisone Esters**Merck Institute for Therapeutic Research, West Point, Pa.

1957 • 275 citations

Corticosteroids inhibit prostaglandin production by rheumatoid synovia

1975 • 261 citations

INHIBITION OF HUMAN PREMATURE LABOR BY INDOMETHACIN

1975 • 260 citations

Prostaglandins in Cellular Biology

1972 • 260 citations

APATITE DEPOSITION DISEASE

1976 • 244 citations

The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material.

1953 • 240 citations

Pharmacokinetics of indomethacin

1975 • 238 citations

Perspectives in Nonsteroidal Anti‐inflammatory Agents

1972 • 213 citations

Action of sodium salicylate and related compounds on tissue metabolism in vitro.

1956 • 212 citations

15-Hydroxyprostaglandin dehydrogenase. A review

1976 • 209 citations

Relationship between inhibition of prostaglandin synthesis and drug efficacy: Support for the current theory on mode of action of aspirin-like drugs

1972 • 207 citations

Indomethacin-induced intestinal lesions in the rat

1970 • 199 citations

Importance of fundamental principles in drug evaluation

1968 • 196 citations

Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells

1975 • 184 citations

Complement-derived leukotactic factors in inflammatory synovial fluids of humans

1971 • 183 citations

Scandinavian Journal of Clinical and Laboratory Investigation

1949 • 179 citations

Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition

1976 • 176 citations

Enterohepatic circulation of indomethacin and its role in intestinal irritation

1975 • 170 citations

Non-Steroid Anti-Inflammatory Agents

1963 • 169 citations

A histopathological and pharmacological analysis of the mode of action of non‐steroidal anti‐inflammatory drugs

1971 • 165 citations

The metabolism of indomethacin in man.

1972 • 159 citations

Indomethacin-Responsive Hypercalcemia in a Patient with Renal-Cell Adenocarcinoma

1974 • 159 citations

Crystal and molecular structure of an antiinflammatory agent, indomethacin, 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid

1972 • 157 citations

Prostaglandin Production and Bone Resorption by Dental Cysts

1973 • 157 citations

The displacement of phenylbutazone-14C and warfarin-14C from human albumin by various drugs and fatty acids

1968 • 154 citations

Displacement of One Drug by Another from Carrier or Receptor Sites

1965 • 152 citations

Kinetics of indomethacin absorption, elimination, and enterohepatic circulation in man

1976 • 151 citations

On the Formation and Effects of Thromboxane A₂ in Human Platelets

1976 • 150 citations

Identification of the biologically active form of sulindac.

1977 • 136 citations

Effects of anti-inflammatory drugs on the stability of rat liver lysosomes in vitro

1971 • 133 citations

Prostaglandins

1972 • 132 citations

Neutrophil Proteases in Inflammation

1972 • 131 citations

Prostaglandin-like Activity in Ocular Inflammation

1972 • 131 citations

Prostaglandins and Aspirin

1971 • 130 citations

Reaction thresholds to pressure in edematous hindpaws of rats and responses to analgesic drugs.

1965 • 126 citations

A Possible Basis for the Anti-inflammatory Activity of Salicylates and other Non-Hormonal Anti-Rheumatic Drugs

1958 • 126 citations

Side-effects of indomethacin.

1967 • 125 citations

Indomethacin block of normal onset of parturition in primates

1974 • 122 citations

Treatment of adjuvant arthritis in rats with anti‐inflammatory drugs

1966 • 119 citations

Immunopathology of Inflammation

1972 • 117 citations

Bone Resorption in Tissue Culture and its Relevance to Periodontal Disease

1973 • 114 citations

INHIBITION OF THE PROSTAGLANDIN SYNTHETASE SYSTEMS IN OCULAR TISSUES BY INDOMETHACIN

1974 • 113 citations

New Antiarthritic Steroids

1955 • 111 citations

In vitro stimulation of lymphocytes by neutral proteinases from human polymorphonuclear leukocyte granules.

1976 • 111 citations

Intradermal Anti-Prostaglandin Agents and Sunburn

1974 • 110 citations

A model for the prostaglandin synthetase cyclooxygenation site and its inhibition by antiinflammatory arylacetic acids

1977 • 108 citations

An Enzymatic Mechanism for the Antithrombotic and Antihemostatic Actions of Aspirin

1974 • 107 citations

PROPERTIES OF A SIMPLIFIED BIOASSAY FOR ADRENOCORTICOTROPHIC ACTIVITY USING THE STEROIDOGENIC RESPONSE OF ISOLATED ADRENAL CELLS

1973 • 107 citations

Output of prostaglandins from the rabbit kidney, its increase on renal nerve stimulation and its inhibition by indomethacin

1972 • 104 citations

Mechanism of steroid action in inflammation: Inhibition of prostaglandin synthesis and release

1976 • 103 citations

Prostaglandins, indomethacin and dysmenorrhea

1976 • 102 citations

Pain and analgesia evaluated by the intraperitoneal bradykinin‐evoked pain method in man

1967 • 100 citations

Prostaglandin Production by Experimental Tumours and Effects of Anti-inflammatory Compounds

1972 • 100 citations

Comparative effect of antirheumatic drugs on adjuvant-induced polyarthritis in rats.

1966 • 99 citations

Role of inhibition of gastric mucous secretion in the phenomenon of gastric mucosal injury by indomethacin

1967 • 98 citations

Topical indomethacin and sunburn.

1974 • 97 citations

Some characteristics of the prostaglandin synthesizing system in rabbit kidney microsomes

1975 • 95 citations

The effect of several ulcerogenic drugs on the canine gastric mucosal barrier.

1972 • 95 citations

NARCOTIC AND NON-NARCOTIC ANALGESICS WHICH BLOCK VISCERAL PAIN EVOKED BY INTRA-ARTERIAL INJECTION OF BRADYKININ AND OTHER ALGESIC AGENTS.

1964 • 93 citations

Indomethacin: A survey of clinical trials

1968 • 91 citations

The influence of psychotropic drugs on prostaglandin biosynthesis

1974 • 90 citations

Simultaneous pharmacokinetics of indomethacin in serum and synovial fluid.

1973 • 89 citations

Empire Rheumatism Council. Cortisone/Aspirin Trial: Multi-Centre Controlled Trial Comparing Cortisone Acetate and Acetyl Salicylic Acid in the Long-Term Treatment of Rheumatoid Arthritis

1955 • 89 citations

Lack of covalent modification of prostaglandin synthetase (cyclo-oxygenase) by indomethacin

1977 • 88 citations

Proteolytic action on insoluble epidermal “keratin” and the nature of the epidermal proteins solubilized

1968 • 85 citations

THE METABOLITES OF INDOMETHACIN, A NEW ANTI-INFLAMMATORY DRUG.

1964 • 85 citations

The uncoupling of oxidative phosphorylation as a mechanism of drug action.

1955 • 84 citations

Suppression of urate crystal‐induced canine joint inflammation by heterologous anti‐polymorphonuclear leukocyte Serum

1968 • 84 citations

Topical indomethadn and sunburn

2006 • 84 citations

16-METHYLATED STEROIDS. II. 16α-METHYL ANALOGS OF CORTISONE, A NEW GROUP OF ANTI-INFLAMMATORY STEROIDS. 9α-HALO DERIVATIVES

1958 • 83 citations

Effects of prostaglandins on the stomach and the intestine

1974 • 81 citations

THE EFFECT OF INDOMETHACIN ON THE RELEASE OF PROSTAGLANDIN E₂ AND ACETYLCHOLINE FROM GUINEA‐PIG ISOLATED ILEUM AT REST AND DURING FIELD STIMULATION

1974 • 81 citations

Cutaneous Effects of Topical Indomethacin, An Inhibitor of Prostaglandin Synthesis, on Uv-Damaged Skin

1975 • 81 citations

Annals of Physical Medicine

1952 • 79 citations

Nonsteroid Anti-Inflammatory Agents

1973 • 77 citations

Physiologic disposition and metabolic fate of a new anti-inflammatory agent, cis-5-fluro-2-methyl-1-(p-(methylsulfinyl)-benzylidenyl)-indene-3-acetic acid in the rat, dog, rhesus monkey, and man.

1973 • 77 citations

Prostaglandins and anti-inflammatory drugs in the dog knee joint

1972 • 74 citations

Multiple sites of interaction between prostaglandins and non-steroidal anti-inflammatory agents

1975 • 73 citations

Indomethacin, Reduced Retinal Sensitivity, and Corneal Deposits

1968 • 73 citations

Effect of various drugs on carrageenin-induced oedema in the rat hind paw

1964 • 73 citations

Steroid hormones, anti-inflammatory steroids and prostaglandins

1976 • 72 citations

Indomethacin in Rheumatic Diseases: A Controlled Clinical Trial

1964 • 71 citations

Aspirin as a quantitative acetylating reagent for the fatty acid oxygenase that forms prostaglandins

1976 • 71 citations

Augmented Noradrenaline Release Following Nerve Stimulation after Inhibition of Prostaglandin Synthesis with Indomethacin

1972 • 70 citations

Role of the entero-hepatic cycle of indomethacin on its metabolism, distribution in tissues and its excretion by rats, dogs and monkeys

1970 • 70 citations

Drug-protein binding

1973 • 69 citations

Prostaglandin and eye

1973 • 69 citations

An extended study of indomethacin. I. Clinical pharmacology.

1966 • 68 citations

The renal excretion of indomethacin and its inhibition by probenecid

1968 • 68 citations

Protein Binding of Indomethacin: Binding of Indomethacin to Human Plasma Albumin and its Displacement from Binding by Ibuprofen, Phenylbutazone and Salicylate, <i>in vitro</i>

1974 • 67 citations

The effect of indomethacin on HMG-HCG induced ovulation in the rhesus monkey

1975 • 65 citations

Arthritis and rheumatism

1982 • 65 citations

Anti‐inflammatory drugs

1974 • 64 citations

Intestinal Metabolism of Phenacetin in the Rat: Effect of Charcoal-Broiled Beef and Rat Chow

1975 • 64 citations

Interactions of aspirin with nonsteroidal antiinflammatory drugs in man

1973 • 64 citations

Naproxen‐aspirin interactions in man

1974 • 63 citations

Inhibition by indomethacin and aspirin of 15-hydroxy-prostaglandin dehydrogenase

1974 • 62 citations

Effects of indomethacin on renal inner medullary plasma flow

1974 • 61 citations

Lysosome membrane stabilization in vivo: effects of steroidal and nonsteroidal anti-inflammatory drugs on the integrity of rat liver lysosomes.

1972 • 60 citations

Nonsteroidal Anti-Inflammatory Drugs

1974 • 59 citations

INTERACTION BETWEEN ASPIRIN AND INDOMETHACIN IN THE TREATMENT OF RHEUMATOID ARTHRITIS

1970 • 59 citations

Inhibition of indomethacin-induced gastric ulceration in the rat by perorally-administered synthetic and natural prostaglandin analogues

1974 • 58 citations

The effect of aspirin on serum indomethacin

1972 • 58 citations

The Effect of Various Prostaglandins and a Prostaglandin Synthetase Inhibitor on Rat Anterior Pituitary Cyclic AMP Levels and Hormone Release in Vitro

1975 • 58 citations

An Extended Study of Indomethacin

1966 • 58 citations

Reduction by indomethacin of furosemide effects in the rabbit

1976 • 58 citations

Cartilage cyclic nucleotide phosphodiesterase: Inhibition by anti-inflammatory agents

1974 • 57 citations

Prostaglandin synthesis, inhibition, and intraocular pressure.

1973 • 57 citations

Some pharmacodynamic properties of carrageenin in the rat

1970 • 57 citations

The antihypertensive action of arachidonic acid in the spontaneous hypertensive rat and its antagonism by anti-inflammatory agents

1973 • 57 citations

Mode of stabilizing action of non-steroid anti-inflammatory drugs on erythrocyte membrane

1970 • 57 citations

Prostaglandin e₁ (pge₁) suppression of adjuvant arthritis histopathology

1973 • 57 citations

Comparative effects of aspirin and diflunisal on prostaglandin synthetase from human platelets and sheep seminal vesicles.

1977 • 56 citations

Jejunal ulcers produced by indomethacin

1969 • 56 citations

Prostaglandin synthetase inhibitors and leucocytic emigration

1975 • 56 citations

Biochemical properties of anti-inflammatory drugs—VIII

1966 • 55 citations

Inhibitory effects of indomethacin, aspirin and certain other drugs on inflammations induced in rat and dog by carrageenan, sodium urate and ellagic acid.

1970 • 54 citations

Indomethacin--aspirin interaction: a clinical appraisal.

1975 • 54 citations

Inhibiton of Furosemide Induced Increase in Renal Blood Flow by Indomethacin

1975 • 52 citations

Indomethacin Treatment of Pericarditis in Chronic Hemodialysis Patients

1975 • 52 citations

Prostaglandins as intracellular messengers

1975 • 51 citations

Acta Pharmacologica et Toxicologica

1946 • 51 citations

NOCICEPTIVE THRESHOLDS AS AFFECTED BY PARENTERAL ADMINISTRATION OF IRRITANTS AND OF VARIOUS ANTINOCICEPTIVE DRUGS.

1965 • 51 citations

A three-month trial of indomethacin in rheumatoid arthritis, with special reference to analysis and inference

1967 • 50 citations

Antagonism of the gastrointestinal ulcerogenic effect of some nonsteroidal anti-inflammatory agents by sodium salicylate

1976 • 50 citations

Comparative effects of salicylic acid, phenylbutazone, probenecid and other anions on the metabolism, distribution and excretion of indomethacin by rats

1970 • 50 citations

Indomethacin potentiates PGE1 stimulated cyclic AMP accumulation in human synoviocytes

1974 • 50 citations

Enzyme Release from Guinea-pig Polymorphonuclear Leucocyte Lysosomes Inhibited in vitro by Anti-Inflammatory Drugs

1972 • 50 citations

THE CLINICAL SIGNIFICANCE OF INDOMETHACIN‐PROBENECID INTERACTION

1974 • 49 citations

Medicina Experimentalis

1959 • 48 citations

The Gastric Mucous Barrier

1968 • 47 citations

Failure of Indomethacin and Warfarin to Interact in Normal Human Volunteers

1975 • 47 citations

Effects of indomethacin on moloney sarcoma virus-induced tumors

1974 • 46 citations

5-Benzoyl-1-methylpyrrole-2-acetic acids as antiinflammatory agents

1971 • 46 citations

Metabolism of Tryptophan in Rheumatoid Arthritis

1962 • 46 citations

A clinical trial of indomethacin in rheumatoid arthritis

1965 • 46 citations

Pharmacologic evaluation of tolectin (tolmetin, mcn-2559) and mcn-2891, two anti-inflammatory agents.

1973 • 45 citations

Indomethacin in rheumatoid arthritis: an evaluation of its anti-inflammatory and side effects.

1967 • 44 citations

Prostaglandins and renal function II. The effect of prostaglandin inhibition on autoregulation of blood flow in the intact kidney of the dog

1975 • 44 citations

Effect of drugs on urate binding to plasma proteins

1969 • 43 citations

Acetylenic Analog of Arachidonate That Acts Like Aspirin on Platelets

1974 • 43 citations

THE BLOCKADE OF LH RELEASE BY INDOMETHACIN¹²

1974 • 43 citations

Synthesis and antiinflammatory activity of a series of 2-aroyl-1,1a,2,6b-tetrahydrocycloprop[b]indole-1-carboxylic acids

1974 • 42 citations

Ocular Absorption of Indomethacin by the Rabbit

1972 • 42 citations

Peptic Ulcer and Rheumatoid Arthritis

1965 • 42 citations

Inhibition of glucosamine‐6‐PO₄ synthesis by salicylate and other anti‐inflammatory agents in vitro

1961 • 40 citations

THE IDENTIFICATION OF A FLUORESCENT REDUCING SUBSTANCE IN THE URINE OF PATIENTS WITH RHEUMATOID ARTHRITIS: THE EXCRETION OF 3-HYDROXYANTHRANILIC ACID IN THIS AND OTHER CONDITIONS

1960 • 40 citations

The ability of nonsteroid anti-inflammatory compounds to accelerate a disulfide interchange reaction of serum sulfhydryl groups and 5,5′-dithiobis(2-nitrobenzoic acid)

1967 • 39 citations

Arthritis and Rheumatism

1968 • 39 citations

Prostaglandins as regulators of bradykinin responses

1973 • 39 citations

Antiinflammatory activity of indomethacin and plasma corticosterone in rats.

1968 • 37 citations

Protection by spironolactone and oxandrolone against chronic digitoxin or indomethacin intoxication

1971 • 37 citations

Acute Inflammatory Response

1965 • 37 citations

The Synthesis of Tryptamines Related to Serotonin

1955 • 37 citations

The effects of arachidonic acid, prostaglandin E2 and prostaglandin F2alpha on the longitudinal stomach strip of the rat.

1973 • 36 citations

Arthritis and Rheumatism

1966 • 36 citations

Inhibition of ethacrynic acid induced increase in renal blood flow by indomethacin

1974 • 36 citations

Effect of concurrent administration of aspirin and indomethacin on serum concentrations

1974 • 36 citations

Interactions of aspirin, indomethacin and other drugs in adjuvant-induced arthritis in the rat.

1973 • 35 citations

Effect of Nonsteroid Anti-Inflammatory and Antipyretic Drugs on Prostaglandin Biosynthesis by Human Skin

1973 • 35 citations

Gazzetta medica italiana

1854 • 34 citations

Inhibitory effects by anti-inflammatory drugs on enzyme release from rabbit polymorphonuclear leukocyte lysosomes

1975 • 34 citations

Concerning the regulation of some diverse biochemical reactions, underlying the inflammatory response, by salicylic acid, phenylbutazone and other acidic antirheumatic drugs

1965 • 34 citations

METABOLISM OF HYDROCORTISONE DURING INFLAMMATION¹

1958 • 34 citations

Regimen of indomethacin therapy in acute gouty arthritis.

1967 • 34 citations

Aspirin and Algesimetry

1959 • 34 citations

Treatment of Osteo-arthritis of the Hip with Indomethacin: A Controlled Clinical Trial

1964 • 33 citations

Interaction of aspirin with nonsteroidal anti-inflammatory drugs in rats

1968 • 32 citations

Inhibition of functional vasodilatation and prostaglandin formation in rabbit adipose tissue by indomethacin and aspirin

1973 • 32 citations

Pyretogenic effects of bacterial lipopolysaccharide and the assay of antipyretic drugs in rats

1963 • 32 citations

Biochemical properties of anti-inflammatory drugs—VI

1965 • 32 citations

Preparation and antiinflammatory properties of some 1-substituted 3-(5-tetrazolylmethyl)indoles and homologs

1969 • 32 citations

Delay of erythema of human skin by anti‐inflammatory drugs after ultraviolet irradiation

1972 • 31 citations

Indomethacin, a new anti-inflammatory drug: Its potential use as a laboratory tool

1965 • 30 citations

Indomethacin in rheumatoid arthritis. A comparative objective evaluation with adrenocorticosteroids

1965 • 30 citations

THE ACUTE INFLAMMATORY RESPONSE

1965 • 30 citations

Action of anti-inflammatory agents upon blood and histopathologic changes induced by periarthritis in rats

1966 • 30 citations

Are platelets important in inflammation?

1975 • 30 citations

Synthetic Anti-Inflammatory Drugs: Concepts of Their Mode of Action

1966 • 29 citations

Ulcerogenic potential of indomethacin in arthritic and non-arthritic rats

1973 • 29 citations

Effects of pharmacologic agents on release of lysosomal enzymes from alveolar mononuclear cells.

1975 • 29 citations

Nonsteroid Anti-Inflammatory Agents

1966 • 28 citations

Indomethacin in Ocular Inflammation in Rabbits

1967 • 28 citations

Quantal Responses in the Randall-Selitto Assay

1971 • 28 citations

JOURNAL OF PHARMACY AND PHARMACOLOGY

1966 • 28 citations

Nonsteroid Anti-Inflammatory Agents

1970 • 28 citations

Morphine hyperthermia in the rat: its attenuation by physostigmine

1972 • 28 citations

Comparative activities, tolerances and safety of nonsteroidal anti-inflammatory agents in rats.

1975 • 28 citations

Studies on phagocytosis. II. The effect of nonsteroidal anti-inflammatory drugs on phagocytosis and on urate crystal-induced canine joint inflammation.

1972 • 28 citations

THE EFFECT OF FRUSEMIDE ON INDOMETHACIN PLASMA LEVELS

1974 • 28 citations

VISCERAL RECEPTORS AND VISCERAL PAIN

1960 • 27 citations

Pharmacological properties of some antimetabolites of serotonin having unusually high activity on isolated tissues.

1954 • 27 citations

Displacement of Thiopental from Plasma Proteins by Nonsteroidal Anti-inflammatory Agents

1973 • 27 citations

The pharmacology of 2,3-bis-(p-methoxyphenyl)-indole (indoxole).

1967 • 26 citations

Quantitative measurement of gastrointestinal bleeding in rats: The effect of nonsteroidal anti-inflammatory drugs

1974 • 26 citations

Excretion of a tryptophan metabolite in rheumatoid arthritis

1963 • 26 citations

The effect of buffered aspirin on plasma indomethacin

1975 • 26 citations

Effects of anti-inflammatory 2-aryl-1,3-indandiones on oxidative phosphorylation in rat liver mitochondria

1975 • 26 citations

Species Differences in Susceptibility to the Gastro-Ulcerogenic Action of Anti-Inflammatory Agents

1974 • 25 citations

Basal and Histamine-Stimulated Human Gastric Acid Secretion

1970 • 25 citations

Concerning the regulation of some diverse biochemical reactions underlying the inflammatory response by salicylic acid, phenylbutazone and other acidic antirheumatic drugs

1966 • 25 citations

Effect of some uricosuric and anti-inflammatory drugs on the binding of uric acid to human serum albumin in vitro.

1970 • 25 citations

Interactions of anti-inflammatory drugs in carrageenan-induced foot edema of the rat.

1970 • 25 citations

Prostaglandine E1 high affinity binding sites of rat thymocytes. Specificity and blockade by non-steroidal antiinflammatory drugs and localization in a plasma membrane enriched fraction

1976 • 25 citations

Plasma bradykininogen levels in adjuvant arthritis and carrageenan inflammation

1969 • 25 citations

Differential properties of prostaglandin and gonadotropin receptors in the bovine corpus lutuem cell membranes

1974 • 24 citations

Prostaglandins in Reproduction

1974 • 24 citations

Inhibition of the primary lesion of adjuvant. induced polyarthritis in rats (18-hour arthritis test) for specific detection of clinically effective anti-arthritic drugs.

1975 • 24 citations

Relative Efficacy of Indomethacin and Acetylsalicylic Acid in Rheumatoid Arthritis

1967 • 24 citations

Effect of Pyridoxine on Tryptophan Metabolism in Rheumatoid Arthritis

1962 • 23 citations

Orally Given Indomethacin and Blood Flow Response to UVL

1975 • 23 citations

Phenoxybenzamine antagonism of tryptamines, their indene isosteres and 5-hydroxytryptamine in the rat stomach fundus preparation.

1968 • 23 citations

Experimental gouty synovitis caused by bacterial endotoxin adsorbed onto urate crystals

1974 • 23 citations

INDOMETHACIN AND BONE PAIN

1974 • 23 citations

Effect of Sulphydryl Binding Compounds on the Inflammatory Process

1969 • 22 citations

Effect of Prostaglandins in Urate Crystal Inflammation

1974 • 22 citations

A sterically efficient synthesis of (Z)-5-fluoro-2-methyl-1-(p-methylthiobenzylidene)-3-indenylacetic acid and its S-oxide, sulindac

1977 • 22 citations

Effects of Antirheumatic Drugs on Human Erythrocyte Membranes

1970 • 21 citations

Potentiation of anticoagulants.

1967 • 21 citations

The inhibitory effect of non-steroidal anti-inflammatory agents on aggregation of red cells in vitro

1970 • 21 citations

Rheumatoid arthritis: A review of recent advances in our knowledge concerning pathology, diagnosis, and treatment

1955 • 21 citations

Retinal Function in Patients Treated with Indomethacin

1973 • 21 citations

Rigid analogs of indomethacin

1974 • 20 citations

Indomethacin—Its Rightful Place in Treatment

1970 • 20 citations

Non-steroidal Anti-inflammatory Drugs

2020 • 20 citations

Indomethacin in In-Patient Treatment of Rheumatoid Arthritis

1966 • 20 citations

Coumarin and Indandione Anticoagulants: Potentiators and Antagonists

1969 • 20 citations

A chemical synthesis of I-O-indomethacin-β-D-glucosyluronic acid

1971 • 19 citations

INDOMETHACIN IN SOFT‐TISSUE SPORTS INJURIES

1974 • 19 citations

Modification by Drugs of Urinary Fibrin Fibrinogen Degradation Products in Glomerulonephritis

1972 • 19 citations

Effect of indomethacin on cyclic AMP phosphodiesterase activity in myometrium from pregnant rhesus monkeys

1976 • 19 citations

Abnormal Sulfhydryl-Disulfide Interchange in Serum of Rats with Adjuvant Arthritis: Correction by Anti-inflammatory Agents

1969 • 19 citations

The fibrinolytic activity of N-arylanthranilates

1966 • 18 citations

Studies on the mode of action of non-steroid anti-inflammatory drugs.

1972 • 18 citations

Inhibition of prostaglandin biosynthesis by 2-aryl-1,3-indandiones

1975 • 18 citations

α-2-GP response in adjuvant-induced polyarthritis: An immunoassay for anti-inflammatory activity

1967 • 18 citations

The assay of anti‐pyretic drugs in mice, using intracerebral injection of pyretogenins

1968 • 17 citations

Factors influencing the metabolism and distribution of corticosterone-1,2-3H in the rat.

1966 • 17 citations

A phlogistic function of prostaglandin E1 in urate crystal inflammation.

1974 • 17 citations

The assay of anti-pyretic drugs in mice, using intracerebral injection of pyretogenins.

1968 • 17 citations

Correlation between anti-inflammatory properties and inhibition of prostaglandin biosynthesis in vitro

1975 • 17 citations

Ocular Anti-Inflammatory Therapy

1971 • 17 citations

Inhibition of Carrageenin‐Induced Rat Paw Oedema by Substances Causing a Reduction of Kininogen and Prekallikrein in Plasma

1971 • 17 citations

Cortisol Distribution and Metabolism in Guinea Pigs after High Doses or Treatment for Three Weeks with Indomethacin, Phenylbutazone or Chloroquine

1972 • 17 citations

Clinical Pharmacology and Therapeutics

1977 • 17 citations

Pain Mechanisms

1967 • 16 citations

Indomethacin and Platelet Aggregation in Chronic Glomerulonephritis: Existence of Non-responders

1974 • 15 citations

Anti-inflammatory Drug Mechanisms

1973 • 15 citations

Structure and conformation of the cis and trans isomers of 1-(p-chlorobenzylidene)-2-methyl-5-methoxyindenylacetic acid

1970 • 14 citations

The spontaneously contracting pregnant rat uterus as a model for anti-inflammatory drug activity

1975 • 14 citations

In Vitro Effects of Non-steroidal Anti-inflammatory Drugs (NAIFD)

1969 • 14 citations

Indomethacin Inhibits the Local Shwartzman Reaction

1970 • 14 citations

Effect of some anti-inflammatory drugs on fibroblast-leucocyte interaction in vitro.

1971 • 14 citations

Studies on the acute inflammatory response. 3. Glucocorticoids and vitamin E (in vivo) attenuate thermal labilization of isolated hepatic lysosomes.

1971 • 14 citations

Aggregation of Red Cells and Effects of Nonsteroidal Anti-inflammatory Drugs

1971 • 14 citations

The effects of probenecid upon the individual components of indomethacin elimination.

1977 • 14 citations

An oxygenase from guinea-pig liver which catalyses sulphoxidation

1974 • 14 citations

Drug information bulletin

2013 • 13 citations

Indomethacin and Peptic Ulcer

1965 • 13 citations

Bradykinin and related kinins

1971 • 12 citations

Effect of low-residue foods on indomethacin-induced intestinal lesions in rats

1974 • 12 citations

Correlation of serum indoxole [2,3-bis(p-methoxyphenyl)-indole] levels with biologic activity.

1967 • 11 citations

An Improved Immunogenic Uveitis Test in Rabbits for Evaluation of Anti-inflammatory Compounds

1970 • 11 citations

Factors Influencing the Development of Indomethacin-Induced Intestinal Ulcers in the Rat

1974 • 11 citations

Local activity of anti-inflammatory and irritant agents on rat paw edema induced by carrageenin.

1968 • 11 citations

Antagonism by indomethacin of diuretic response to calcitonin in man.

1975 • 11 citations

Turnover of a Prostaglandin Precursor, Arachidonic Acid, in Rheumatoid Arthritis

1975 • 11 citations

Transposition of drug studies from laboratory to clinic

1960 • 10 citations

Antiinflammatory Compounds Exhibiting Fibrinolytic Activity

1966 • 10 citations

X-ray analysis of d-6-chloro-5-cyclohexylindan-1-carboxylic acid (d-TAI-284).

1975 • 10 citations

Turnover of a Prostaglandin Precursor, Arachidonic Acid, in Rheumatoid Arthritis

1975 • 10 citations

The Use of Indomethacin in Old Age

1965 • 9 citations

The local anti-inflammatory action of non-steroidal compounds on the paw oedema caused by kaolin in the rat.

1967 • 9 citations

[Distribution of indomethacin in blood and synovial fluid of patients with rheumatoid arthritis].

1971 • 9 citations

Increased copper ligand reactivity in the urine of patients with rheumatoid arthritis

1966 • 9 citations

An appraisal of indomethacin.

1967 • 9 citations

Quantitative Analysis of Inorganic Phosphorus and Magnesium in Gingival Fluid

1973 • 9 citations

Distribution, induction and purification of a monooxygenase catalyzing sulphoxidation of drugs

1976 • 9 citations

Prevention of antiinflammatory drug-induced gastric lesions in rats by Abbott-29590

1974 • 8 citations

Hormones and Resistance.

1972 • 8 citations

1-Acylindoles. IV. Novel Syntheses of 1-Benzoylindole-3-aliphatic Acids

1968 • 8 citations

1-Acylindoles. IX. Synthesis of 1-cinnamoyl-5-methoxy-2-methyl-3-indolylaliphatic acids as potential anti-inflammatory agents

1969 • 8 citations

1-p-Chlorobenzyl-5-methylindole-3-acetic Acid. Some 2-Substituted Derivatives

1965 • 8 citations

Distribution and excretion of rifamide in rats and dogs*1

1966 • 7 citations

Effect of pH on Erythrocyte Stabilization by Anti-Inflammatory Drugs

1971 • 7 citations

EXPERIENCE OF THE USE OF INDOMETHACIN IN INFLAMMATORY EYE DISEASES1

1966 • 7 citations

Physiologic Disposition and Metabolic Fate of Indomethacin Analogs I: 1-p-Chlorobenzylidenyl-5-methoxy-2-methylindene-3-acetic Acid

1971 • 7 citations

Effect of catatoxic steroids upon established morbid changes

1971 • 7 citations

Comparative psychopharmacologic investigation of cryogenine, certain non-steroid anti-inflammatory compounds, lupin alkaloids and cyproheptadine.

1971 • 6 citations

The Pathology of the Collagen Diseases

1963 • 6 citations

Newer Drugs For Arthritis

1968 • 6 citations

Derivatives of indole-1-acetic acid as antiinflammatory agents

1972 • 6 citations

Interaction of non-steroidal antiinflammatory agents with corticosterone binding to plasma proteins in the rat.

1969 • 6 citations

Aldehyde analog of indomethacin

1973 • 6 citations

Treatment of adjuvant arthritis with antibradykinin drugs

1970 • 6 citations

Comparative evaluation of the antipyretic activity in normothermic and pyrexial mice, rats, and guinea-pigs.

1967 • 5 citations

The effects of prostaglandins PGE1, PGE2, PGF1a, and PGF2a on canine synovial perfusion

1975 • 5 citations

[The mechanism of action of non-steroid anti-inflammatory drugs].

1971 • 5 citations

Renal Prostaglandins and the Antihypertensive Endocrine Function

1975 • 5 citations

3-Benzoyldifluoromethanesulfonanilide, sodium salt (diflumidone sodium, MBR 4164-8): a new anti-inflammatory agent.

1971 • 5 citations

[On the localization of the tubular effect of some antirheumatic effective substances].

1968 • 5 citations

Correspondence

1966 • 5 citations

Evaluating the Safety of Drugs

1966 • 5 citations

Indomethacin as an Analgesic

1968 • 4 citations

Role of Drug Metabolism in Drug Research and Development: Basic Considerations

1972 • 4 citations

Synthesis and pharmacology of a new potential anti-inflammatory drug, 1-(3',4'-methylenedioxybenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid (ID-955).

1969 • 4 citations

Ocular toxicity of systemic drugs. A review of the effects of seven commonly used agents.

1972 • 4 citations

Effect of anti-inflammatory drugs on plasma corticosterone level in albino rats

1969 • 4 citations

The effect of anti-inflammatory drugs on the protein-binding of [1,2-3H] cortisol in human plasma in vitro

1971 • 4 citations

Indomethacin Induced Ocular Toxicity

1973 • 4 citations

THE TREATMENT OF RHEUMATOID ARTHRITIS WITH INDOMETHACIN

1964 • 4 citations

The therapeutic activity of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid monohydrate glucosamide in rheumatoid arthritis (double blind trial).

1975 • 4 citations

The effect of a new anti-inflammatory agent (5-cyclohexylindan-1-carboxylic acid (BL-2365)) on platelet aggregation.

1972 • 4 citations

Role of Drug Metabolism in Drug Research and Development: Importance of Drug Metabolism in Clinical Pharmacological Evaluation of New Drugs

1972 • 4 citations

Anti-inflammatory activities of 1-cinnamoyl-2-methyl-5-methoxy-3-indolylacetic acid (cinmetacin).

1973 • 4 citations

The Distribution and Metabolism of Cortisol under the Influence of Non‐Steroidal Antirheumatic Drugs

1971 • 4 citations

Differential Effect of Spironolactone on the Ulcerogenic and Anti-Inflammatory Activities of Indomethacin

1970 • 4 citations

Ocular Anti-Inflammatory Therapy

1971 • 4 citations

The use of indometacin for treating diffuse glomerulonephritis under experimental and clinical conditions.

1973 • 4 citations

Role of Drug Metabolism in Drug Research and Development: Pharmaceutical Chemistry Aspects

1972 • 3 citations

Non-steroid anti-inflammatory drugs

2017 • 3 citations

A compactification of locally compact spaces

1972 • 3 citations

Indomethacin Treatment following Surgery for Varicose Veins

1974 • 3 citations

BEHAVIOR OF THE PLASMA LEVEL OF INDOMETHACIN

1964 • 3 citations

Role of Drug Metabolism in Drug Research and Development: Factors Affecting Metabolism of Drugs and Their Pharmacological and Toxicological Activity

1972 • 3 citations

▪ Nonsteroidal Anti-inflammatory Agents

2005 • 3 citations

The synthesis of substituted 1,7H‐pyrindine acetic esters

1970 • 3 citations

EFFECTS OF INDOMETHACIN IN 96 CASES OF RHEUMATIC DISEASES

1964 • 3 citations

[International symposium on inflammation and its therapy--experiences with indomethacin. Florence, April 1 to 4, 1971. Introduction].

1971 • 2 citations

Adequacy of the Preclinical Safety Evaluation

1964 • 2 citations

[Interaction between anticoagulants and indomethacin].

1974 • 2 citations

Synovial fluid and serological changes ater treatment in arthritic diseases.

1968 • 2 citations

[Indomethacin in the treatment of the nephrotic syndrome and residuaproteinuria].

1967 • 2 citations

THE SAFETY EVALUATION OF DRUGS

1964 • 2 citations

Role of Drug Metabolism in Drug Research and Development: View of a Medicinal Chemist

1972 • 1 citations

[INDOMETHACIN IN PRIMARY CHRONIC POLYARTHRITIS: PROPERTIES, COLLATERAL EFFECTS].

1964 • 1 citations

The protein binding of plasma cortisol after therapeutic doses of indomethacin.

1970 • 1 citations

[New nonsteroid antirheumatic drugs in opthalmology].

1971 • 1 citations

Anti-inflammatory Agents

2007 • 1 citations

[Effect of the combination indomethacin and syncumar (acenocoumarol) on the prothrombin levels in the blood plasma].

1967 • 1 citations

[Anti-platelet aggregating drugs in the prevention of thromboembolic diseases].

1975 • 1 citations

Deleted Work

1955 • 0 citations