Antiepileptic Drug Mechanisms of Action

Three types of neuronal calcium channel with different calcium agonist sensitivity

1985 • 2,212 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

1989 • 1,283 citations

P-type calcium channels in rat central and peripheral neurons

1992 • 788 citations

Type I and Type II GABA _A -Benzodiazepine Receptors Produced in Transfected Cells

1989 • 716 citations

Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.

1990 • 647 citations

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons.

1981 • 559 citations

Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug

1986 • 558 citations

Functional properties of recombinant rat GABAA receptors depend upon subunit composition

1990 • 557 citations

Two novel GABAA receptor subunits exist in distinct neuronal subpopulations

1989 • 532 citations

Characterization of ethosuximide reduction of low‐threshold calcium current in thalamic neurons

1989 • 507 citations

Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low‐threshold current.

1989 • 458 citations

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

1991 • 426 citations

Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors

1979 • 408 citations

Differential regulation of γ‐aminobutyric acid receptor channels by diazepam and phenobarbital

1989 • 331 citations

An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

1992 • 281 citations

Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture.

1986 • 272 citations

Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture.

1986 • 237 citations

Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons

1989 • 225 citations

Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture.

1989 • 225 citations

Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture.

1989 • 216 citations

Gamma-aminobutyric acidA receptor structure and function.

1992 • 208 citations

Multiple actions of phenytoin on mouse spinal cord neurons in cell culture.

1983 • 202 citations

Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons

1990 • 197 citations

Comparative Anticonvulsant Activity and Neurotoxicity of Felbamate and Four Prototype Antiepileptic Drugs in Mice and Rats

1986 • 196 citations

Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain

1991 • 191 citations

Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug

1986 • 187 citations

Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin

1993 • 145 citations

Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction

1990 • 145 citations

Phenytoin and Carbamazepine: Potential‐ and Frequency‐Dependent Block of Na Currents in Mammalian Myelinated Nerve Fibers

1989 • 137 citations

Antiepileptic Drug Actions

1989 • 109 citations

Gating scheme for single GABA-activated Cl- channels determined from stability plots, dwell-time distributions, and adjacent-interval durations

1989 • 101 citations

Inhibition by GABA, baclofen and gabapentin of dopamine release from rabbit caudate nucleus: Are there common or different sites of action?

1983 • 97 citations

Intraburst kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture.

1990 • 92 citations

ANTICONVULSANT THERAPY, MEGALOBLASTIC HAEMOPOIESIS AND FOLIC ACID METABOLISM

1966 • 82 citations

Gabapentin decreases monoamine release without affecting acetylcholine release in the brain.

1985 • 67 citations

Cloned GABA receptors are maintained in a stable cell line: allosteric and channel properties

1990 • 56 citations

Effect of Anticonvulsant Felbamate on GABA_A Receptor System

1991 • 50 citations

Effects of chlordiazepoxide, chlorpromazine, diazepam, diphenylhydantoin, flunitrazepam and haloperidol on the voltage-dependent sodium current of isolated mammalian brain neurons

1989 • 47 citations

Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin.

1989 • 33 citations

Recent advances in epilepsy, Vol. 2

1985 • 32 citations

Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice

1991 • 26 citations

Comparison of gabapentin with other antiepileptic and GABAergic drugs

1991 • 23 citations

Antiepileptic Drugs, 3rd edition

1990 • 6 citations