Antitumor Effect of CD40 Ligand: Elicitation of Local and Systemic Antitumor Responses by IL-12 and B7

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Human tumor antigens recognized by T lymphocytes.

1996 • 860 citations

Specific T Helper Cell Requirement for Optimal Induction of Cytotoxic T Lymphocytes against Major Histocompatibility Complex Class II Negative Tumors

1998 • 611 citations

CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40.

1993 • 593 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

The Role of CD40 Ligand in Costimulation and T‐Cell Activation

1996 • 441 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

1996 • 421 citations

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

1996 • 416 citations

Cancer vaccines based on the identification of genes encoding cancer regression antigens

1997 • 395 citations

The role of CD40 in the regulation of humoral and cell-mediated immunity

1994 • 376 citations

CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major

1996 • 332 citations

CD40-gp39 INTERACTIONS PLAY A CRITICAL ROLE DURING ALLOGRAFT REJECTION

1996 • 331 citations

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 • 329 citations

Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis Infection

1996 • 311 citations

Protective Role of CD40 in Leishmania major Infection at Two Distinct Phases of Cell-Mediated Immunity

1996 • 302 citations

The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity.

1988 • 276 citations

Modulation of T-cell function by gliomas

1991 • 241 citations

CD40 and Its Ligand in Host Defense

1996 • 236 citations

Genes Coding for Tumor Antigens Recognized by Cytolytic T Lymphocytes

1995 • 233 citations

TAP off - tumors on

1997 • 215 citations

Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction.

1996 • 197 citations

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.

1994 • 187 citations

CD40 Ligation on Human Cord Blood CD34+Hematopoietic Progenitors Induces Their Proliferation and Differentiation into Functional Dendritic Cells

1997 • 161 citations

Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule

1995 • 156 citations

Ligation of B7 with CD28/CTLA‐4 on T cells results in CD40 ligand expression, interleukin‐4 secretion and efficient help for antibody production by B cells

1993 • 153 citations

The Complexities of T‐Cell Co‐stimulation: CD28 and Beyond

1996 • 148 citations

CD40 Ligand Induces an Antileukemia Immune Response In Vivo

1997 • 142 citations

Antitumor immunity elicited by tumor cells transfected with B7-2, a second ligand for CD28/CTLA-4 costimulatory molecules.

1995 • 133 citations

Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.

1996 • 128 citations

Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin‐12 for interferon‐γ production

1996 • 126 citations

Perspectives on the Role of Mhc Antigens in Normal and Malignant Cell Development

1989 • 124 citations

CD40 ligand is a T cell growth factor

1993 • 123 citations

Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.

1996 • 108 citations

Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154.

1997 • 106 citations

CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.

1996 • 101 citations

The differential role of CD86 and CD80 co-stimulatory molecules in the induction and the effector phases of contact hypersensitivity

1996 • 88 citations

Tumor immunity as autoimmunity: tumor antigens include normal self proteins which stimulate anergic peripheral T cells

1993 • 74 citations

Antitumor Responses Induced by Transgenic Expression of CD40 Ligand

1997 • 66 citations

Exogenous CD40 ligand induces a pulmonary inflammation response.

1997 • 58 citations

B7-negative versus B7-positive P815 tumor: differential requirements for priming of an antitumor immune response in lymph nodes.

1997 • 38 citations

TAP off — tumors on

1997 • 33 citations

Activated B cells express CD28/B7-independent costimulatory activity.

1996 • 26 citations