Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin‐12 for interferon‐γ production

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40.

1993 • 593 citations

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1995 • 476 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

Human TH1 and TH2 Subsets: Regulation of Differentiation and Role in Protection and Immunopathology

1992 • 383 citations

The role of CD40 in the regulation of humoral and cell-mediated immunity

1994 • 376 citations

Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes.

1995 • 368 citations

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

1994 • 367 citations

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

1994 • 367 citations

Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help).

1992 • 357 citations

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

1996 • 349 citations

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes.

1992 • 342 citations

Activated human T cells express a ligand for the human B cell‐associated antigen CD40 which participates in T cell‐dependent activation of B lymphocytes

1992 • 323 citations

CD40 is functionally expressed on human thymic epithelial cells.

1992 • 261 citations

CD40 ligand and its role in X-linked hyper-IgM syndrome

1993 • 257 citations

CD40 preferentially costimulates activation of CD4+ T lymphocytes.

1994 • 255 citations

Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice.

1996 • 237 citations

Human T cell activation with phytohemagglutinin. The function of IL-6 as an accessory signal.

1988 • 193 citations

Ligation of B7 with CD28/CTLA‐4 on T cells results in CD40 ligand expression, interleukin‐4 secretion and efficient help for antibody production by B cells

1993 • 153 citations

Role of CD40-CD40-ligand interaction in Ig-isotype switching

1993 • 69 citations

Generation of monoclonal antibodies to human lymphocyte cell surface antigens using insect cell expressing recombinant proteins

1992 • 38 citations