The GTP binding proteins Gem and Rad are negative regulators of the Rho–Rho kinase pathway

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

2001 • 1,239 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

2001 • 852 citations

ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

1996 • 757 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts

2000 • 664 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

An essential part for Rho–associated kinase in the transcellular invasion of tumor cells

1999 • 609 citations

Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation

1997 • 576 citations

Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo

1999 • 559 citations

Inhibitory Phosphorylation Site for Rho-associated Kinase on Smooth Muscle Myosin Phosphatase

1999 • 522 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Regulation and Functions of Rho-Associated Kinase

2000 • 500 citations

Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

1998 • 465 citations

Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells.

1995 • 436 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase.

1985 • 340 citations

Rho-Kinase–Mediated Contraction of Isolated Stress Fibers

2001 • 309 citations

Rad: a Member of the Ras Family Overexpressed in Muscle of Type II Diabetic Humans

1993 • 301 citations

Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem

2001 • 287 citations

Myosin II activation promotes neurite retraction during the action of Rho and Rho‐kinase

1998 • 243 citations

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation

1998 • 243 citations

Specific Localization of Serine 19 Phosphorylated Myosin II during Cell Locomotion and Mitosis of Cultured Cells

1998 • 231 citations

Role of Actin Cortex in the Subplasmalemmal Transport of Secretory Granules in PC-12 Cells

2000 • 215 citations

Transformation mediated by RhoA requires activity of ROCK kinases

1999 • 209 citations

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

1997 • 176 citations

Gem: an Induced, Immediate Early Protein Belonging to the Ras Family

1994 • 172 citations

Cell motility mediated by rho and rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma

1999 • 159 citations

An Inhibitory Role of Rho in the Vasopressin-mediated Translocation of Aquaporin-2 into Cell Membranes of Renal Principal Cells

2001 • 158 citations

Signal Pathways Which Promote Invasion and Metastasis: Critical and Distinct Contributions of Extracellular Signal-Regulated Kinase and Ral-Specific Guanine Exchange Factor Pathways

2001 • 157 citations

A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival

1999 • 106 citations

Actin cytoskeleton and cell signaling

2000 • 97 citations

Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases

2000 • 96 citations

Rem Is a New Member of the Rad- and Gem/Kir Ras-related GTP-binding Protein Family Repressed by Lipopolysaccharide Stimulation

1997 • 95 citations

[24] Biological assays for cellular transformation

1994 • 95 citations

Rad and Rad-related GTPases Interact with Calmodulin and Calmodulin-dependent Protein Kinase II

1997 • 92 citations

Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.

1994 • 83 citations

The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9

2001 • 80 citations

Calmodulin Binds to and Inhibits GTP Binding of the Ras-like GTPase Kir/Gem

1996 • 60 citations

Rad, a Novel Ras-related GTPase, Interacts with Skeletal Muscle β-Tropomyosin

1996 • 57 citations

A Drosophila Homolog of LIM-Kinase Phosphorylates Cofilin and Induces Actin Cytoskeletal Reorganization

2000 • 56 citations

The Insert Region of RhoA Is Essential for Rho Kinase Activation and Cellular Transformation

2001 • 47 citations

Phosphorylation-Dependent Association of the Ras-Related GTP-Binding Protein Rem with 14-3-3 Proteins

1999 • 44 citations

The Gem GTP-binding protein promotes morphological differentiation in neuroblastoma

2001 • 44 citations

Ges, a Human Gtpase of the Rad/Gem/Kir Family, Promotes Endothelial Cell Sprouting and Cytoskeleton Reorganization

2000 • 39 citations

The Ras-Related Protein Rad Associates with the Cytoskeleton in a Non-Lipid-Dependent Manner

1998 • 37 citations

Effects of phosphorylation on function of the Rad GTPase

1998 • 35 citations

Kir, a novel Ras-family G-protein, induces invasive pseudohyphal growth in Saccharomyces cerevisiae.

1995 • 25 citations