Superantigen Mediated Shock: A Cytokine Release Syndrome

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Galactosamine-induced sensitization to the lethal effects of endotoxin.

1979 • 940 citations

Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

1991 • 783 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

1992 • 595 citations

Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice.

1987 • 560 citations

Galactosamine hepatitis: Key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death

2005 • 441 citations

Superantigens interact with MHC class II molecules outside of the antigen groove

1990 • 438 citations

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

1991 • 395 citations

High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR

1989 • 388 citations

In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

1990 • 370 citations

Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin

1986 • 340 citations

Clonal expansion precedes anergy and death of V_β8⁺ peripheral T cells responding to staphylococcal enterotoxin B in vivo

1991 • 330 citations

IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-alpha.

1992 • 285 citations

Class II MHC Molecules Are Specific Receptors for Staphylococcus Enterotoxin A

1989 • 267 citations

HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells.

1990 • 253 citations

Toxic shock syndrome toxin 1 as an inducer of human tumor necrosis factors and gamma interferon.

1988 • 221 citations

Nitric oxide synthesis in endothelial cells: evidence for a pathway inducible by TNF-alpha

1991 • 200 citations

Binding of staphylococcal enterotoxin A to accessory cells is a requirement for its ability to activate human T cells.

1988 • 187 citations

Evidence for a viral superantigen in humans

1992 • 167 citations

Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion.

1990 • 163 citations

Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone

1991 • 161 citations

Transcriptional activation of IL-1 beta and tumor necrosis factor-alpha genes by MHC class II ligands.

1991 • 155 citations

Major histocompatibility complex independent clonal T cell anergy by direct interaction of Staphylococcus aureus enterotoxin B with the T cell antigen receptor.

1992 • 140 citations

Staphylococcal Enterotoxins, Toxic Shock Syndrome Toxin and Streptococcal Pyrogenic Exotoxins: A Comparative Study of Their Molecular Biology

2015 • 139 citations

Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins.

1990 • 132 citations

Different staphylococcal enterotoxins bind preferentially to distinct major histocompatibility complex class ii isotypes

1989 • 118 citations

Pathogenesis of the toxic shock syndrome: T cell mediated lethal shock caused by the superantigen TSST‐1

1993 • 117 citations

Kinetics of IL-2 and interferon-γ production, expression of IL-2 receptors, and cell proliferation in human mononuclear cells exposed to staphylococcal enterotoxin A

1985 • 113 citations

In vivo responses of CD4⁺ and CD8⁺ cells to bacterial superantigens

1992 • 109 citations

Macrophage cytostatic effect on Trypanosoma musculi involves an L-arginine-dependent mechanism.

1991 • 108 citations

The α1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin-1

1990 • 100 citations

The staphylococcal toxic shock syndrome toxin 1 triggers B cell proliferation and differentiation via major histocompatibility complex-unrestricted cognate T/B cell interaction.

1989 • 96 citations

Dendritic cells are potent antigen-presenting cells for microbial superantigens.

1992 • 89 citations

Antigen recognition properties of mutant V beta 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor.

1993 • 89 citations

Yersinia enterocolitica produces superantigenic activity.

1992 • 81 citations

The genetic contribution to human T-cell receptor repertoire.

1991 • 76 citations

Induction of nitric oxide synthase activity by toxic shock syndrome toxin 1 in a macrophage-monocyte cell line.

1992 • 71 citations

Clonal deletion as direct consequence of an in vivo T cell response to bacterial superantigen

1993 • 68 citations

Clonal analysis of human T cell activation by the Mycoplasma arthritidis mitogen (MAS)

1988 • 65 citations

Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells.

1991 • 57 citations

Signal Transduction by Microbial Superantigens via MHC class II Molecules

1993 • 57 citations

Microbial superantigens induce NF-kappa B in the human monocytic cell line THP-1.

1993 • 55 citations

Bacterial superantigens induce rapid and T cell receptor V beta-selective down-regulation of L-selectin (gp90Mel-14) in vivo.

1993 • 47 citations

Acquired resistance to superantigen-induced T cell shock. V beta selective T cell unresponsiveness unfolds directly from a transient state of hyperreactivity.

1993 • 47 citations

Conventional antigen and superantigen may be coupled to distinct and cooperative T-cell activation pathways.

1991 • 46 citations

The superantigen Pseudomonas exotoxin a requires additional functions from accessory cells for T lymphocyte proliferation

1991 • 40 citations

Staphylococcal Enterotoxins, Toxic Shock Syndrome Toxin and Streptococcal Pyrogenic Exotoxins: A Comparative Study of Their Molecular Biology (Part 1 of 2)

1992 • 35 citations

Binding of toxic shock syndrome toxin‐1 to murine major histocompatibility complex class II molecules

1990 • 34 citations

Role of protein kinase activation in the induction of B cell adhesion by MHC class II ligands.

1992 • 34 citations

The glucocorticoid antagonist RU38486 mimics interleukin‐1 in its sensitization to the lethal and interleukin‐6‐inducing properties of tumor necrosis factor

1992 • 32 citations

Immunoregulatory Effects of Superantigens: Interactions of Staphylococcal Enterotoxins with Host MHC and non‐MHC Products

1993 • 27 citations

Superantigen staphylococcal enterotoxin B-induced T-helper cell activation is independent of CD4 molecules and phosphatidylinositol hydrolysis.

1992 • 25 citations

Effects of Staphylococcal Toxins on T-Cell Activity in vivo

2015 • 18 citations

Effects of Staphylococcal Toxins on T-Cell Activity in vivo

1992 • 7 citations

Clonal unresponsiveness results from an interaction between staphylococcal enterotoxin B and T cells expressing unexpected V_β elements

1992 • 5 citations