Manipulation of the superantigen‐induced lymphokine response. Selective induction of interleukin‐10 or interferon‐γ synthesis in small resting CD4⁺ T cells

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

1991 • 777 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

1991 • 676 citations

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

1991 • 641 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

Assessment of Cytokines by Immunofluorescence and the Paraformaldehyde‐Saponin Procedure

1991 • 465 citations

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

1991 • 406 citations

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

1990 • 386 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Regulation of T‐Cell Activation; Differences among T‐Cell Subsets

1989 • 271 citations

The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent.

1988 • 261 citations

Cloned T Lymphocytes and Monoclonal Antibodies as Probes for Cell Surface Molecules Active in T Cell‐Mediated Cytolysis

1982 • 219 citations

Frequencies of CD4⁺ T cells reactive with Plasmodium chabaudi chabaudi: distinct response kinetics for cells with T_h1 and T_h2 characteristics during infection

1989 • 185 citations

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.

1988 • 172 citations

Production of lymphokine mRNA by CD45R+ and CD45R- helper T cells from human peripheral blood and by human CD4+ T cell clones.

1989 • 169 citations

IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production.

1990 • 155 citations

Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide.

1987 • 140 citations

Selectively increased production of interferon-gamma by subsets of Lyt-2+ and L3T4+ T cells identified by expression of Pgp-1.

1987 • 120 citations

Comparison of diversity and function of house dust mite‐specific T lymphocyte clones from atopic and non‐atopic donors

1990 • 113 citations

Coexpression of granulocyte-macrophage colony-stimulating factor, gamma interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones.

1988 • 106 citations

Two subsets of human CD4⁺T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon‐γ can be defined by the Leu‐18 and UCHLl monoclonal antibodies

1988 • 94 citations

Organization and structure of the mouse interleukin-2 gene

1984 • 83 citations

Analysis by in situ hybridization of cells expressing mRNA for interleukin 4 in the developing thymus and in peripheral lymphocytes from mice.

1988 • 78 citations

Two-step separation of human peripheral blood monocytes on discontinuous density gradients of colloidal silica-polyvinylpyrrolidinone

1977 • 77 citations

Natural effector T lymphocytes in normal mice.

1985 • 70 citations

Structural Differences in Cell Surface T25 Polypeptides from Thymocytes and Cloned T Cells

1981 • 60 citations

Similarity between in vitro and in vivo cellular aging

1983 • 58 citations

Phenotypic and functional alteration of CD4+ T cells after antigen stimulation. Resolution of two populations of memory T cells that both secrete interleukin 4.

1989 • 56 citations

Conventional antigen and superantigen may be coupled to distinct and cooperative T-cell activation pathways.

1991 • 46 citations

Increased frequency of interleukin 4‐producing T cells as a result of polyclonal priming. Use of a single‐cell assay to detect interleukin 4‐producing cells

1991 • 38 citations

Interleukin 2, 4 and 5 are sequentially produced in mitogen‐stimulated murine spleen cell cultures

1990 • 35 citations

Helper interleukins are produced by both CD4 and CD8 splenic T cells after mitogen stimulation

1991 • 31 citations

Interleukin 4 and Interferon Gamma Production in Restimulated CD4⁺ and CD8⁺ Cells Indicates Memory Type Responsiveness

1991 • 31 citations

Differential induction of interferon gamma gene expression after activation of CD4+ T cells by conventional antigen and Mls superantigen.

1991 • 30 citations

Evidence for quantitative and qualitative differences in functional activation of MIs‐reactive T cell clones and hybridomas by antigen or TcR/CD3 antibodies

1991 • 15 citations

Frequencies of T cells secreting IL-2 and/or IL-4 among unprimed CD4+ populations. Evidence that clones secreting IL-2 and IL-4 give rise to clones which secrete only IL-4

1990 • 15 citations

Interferon‐γ and growth factor production by murine T cells derived from three different lymphoid tissues

1991 • 12 citations

Forced Contact between Antigen‐Presenting Cells and T Cells: Consequences for T‐Cell Activation

1989 • 3 citations

Qualitative Shift of Lymphokine Production in Response to Stimulation, as a Consequence of Preactivation In Vivo or In Vitro

1992 • 3 citations