Back to search

Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat.

Data up to Jan 2025

Published1997
Citations93
References48

Total Citations Per Year

Abstract

References (48)

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Synthesis of nitric oxide in CNS glial cells

1993 • 627 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages.

1990 • 511 citations

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma.

1988 • 432 citations

Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

1994 • 389 citations

Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids.

1989 • 339 citations

Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice.

1992 • 299 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study

1993 • 264 citations

Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells.

1982 • 261 citations

Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

1993 • 260 citations

Nitric oxide as a potential pathological mechanism in demyelination: Its differential effects on primary glial cellsin vitro

1994 • 258 citations

Effects of IL-12 on the response and susceptibility to experimental viral infections.

1994 • 233 citations

The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis.

1981 • 215 citations

Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats

1990 • 207 citations

Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100 beta molecule, a calcium binding protein of astroglia.

1994 • 186 citations

IL-12 unmasks latent autoimmune disease in resistant mice.

1996 • 182 citations

Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis

1995 • 181 citations

Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β

1995 • 179 citations

CD4+ suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta.

1991 • 175 citations

Interferon γ, interleukin 4 and transforming growth factor β in experimental autoimmune encephalomyelitis in lewis rats: Dynamics of cellular mrna expression in the central nervous system and lymphoid cells

1995 • 159 citations

Recurrent Experimental Allergic Encephalomyelitis in the Lewis Rat

1974 • 155 citations

Apoptotic elimination of Vβ8.2+ cells from the central nervous system during recovery from experimental autoimmune encephalomyelitis induced by the passive transfer of Vβ8.2+ encephalitogenic T cells

1994 • 113 citations

Staphylococcal enterotoxin B and tumor‐necrosis factor‐α‐induced relapses of experimental allergic encephalomyelitis: Protection by transforming growth factor‐β and interleukin‐10

1995 • 108 citations

Inflammation in the nervous system. Basic mechanisms and immunological concepts.

1991 • 100 citations

Low-dose cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat

1988 • 95 citations

Exogenous nitric oxide regulates IFN-gamma plus lipopolysaccharide-induced nitric oxide synthase expression in mouse macrophages.

1995 • 81 citations

Evidence for suppressor cells in Lewis rats' experimental allergic encephalomyelitis

1977 • 80 citations

Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms.

1996 • 74 citations

Long‐term depletion of cd8+ t cells in vivo in the rat: no observed role for cd8+ (cytotoxic/suppressor) cells in the immunoregulation of experimental allergic encephalomyelitis

1988 • 72 citations

Antigen-specific down-regulation of myelin basic protein-reactive T cells during spontaneous recovery from experimental autoimmune encephalomyelitis: further evidence of apoptotic deletion of autoreactive T cells in the central nervous system

1995 • 64 citations

Apoptosis of T cells and Macrophages in the Central Nervous System of Intact and Adrenalectomized Lewis Rats During Experimental Allergic Encephalomyelitis

1996 • 50 citations

Hypothesis: Antigen-specific T cells prime central nervous system endothelium for recruitment of nonspecific inflammatory cells to effect autoimmune demyelination

1991 • 44 citations

The role of macrophage subpopulations in autoimmune disease of the central nervous system

1996 • 42 citations

Loss rather than downregulation of CD4+ T cells as a mechanism for remission from experimental allergic encephalomyelitis

1993 • 36 citations

Sex difference in Lewis rats in the incidence of recurrent experimental allergic encephalomyelitis

1978 • 33 citations

Regulation of experimental allergic encephalomyelitis☆Part 4. Further characterization of postrecovery suppressor cells

1982 • 30 citations

Studies on the refractoriness to reinduction of experimental allergic encephalomyelitis in Lewis rats that have recovered from one episode of the disease

1990 • 23 citations

On the Existence of Suppressor Cells

1993 • 18 citations

Abrogation of resistance to the reinduction of experimental allergic encephalomyelitis by pertussigen

1982 • 15 citations

The Current Management of Multiple Sclerosis

1984 • 10 citations

Cited By (0)

Loading...
Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis… (1997) – PubMed | Metascience Observatory Explorer