Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin

Regressive Events in Neurogenesis

1984 • 1,330 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

1992 • 1,121 citations

Functional plasticity of microglia: A review

1988 • 931 citations

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

1985 • 881 citations

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

1987 • 806 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Lectin binding by resting and reactive microglia

1987 • 497 citations

Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation

1992 • 486 citations

Brain glia release factors with opposing actions upon neuronal survival

1993 • 437 citations

Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate

1991 • 421 citations

Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers.

1983 • 412 citations

Induction of Neuronal Differentiation in PC12 Cells by B-Cell Stimulatory Factor 2/Interleukin 6

1988 • 402 citations

Advances in cellular neurobiology, 2

1982 • 376 citations

Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia.

1992 • 376 citations

The structural and functional properties of thrombospondin

1986 • 333 citations

Macrophages can modify the nonpermissive nature of the adult mammalian central nervous system

1990 • 308 citations

Naturally occurring cell death in the cerebral cortex of the rat and removal of dead cells by transitory phagocytes

1990 • 308 citations

Isolation and Properties of a Thrombin-sensitive Protein of Human Platelets

1972 • 306 citations

Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.

1988 • 295 citations

AIDS subacute encephalitis. Identification of HIV-infected cells.

1987 • 286 citations

Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain

1989 • 281 citations

Effect of striatal cells on in vitro maturation of mesencephalic dopaminergic neurones grown in serum-free conditions

1980 • 281 citations

The structural and functional properties of thrombospondin

1986 • 261 citations

Transforming growth factor-beta complexes with thrombospondin.

1992 • 256 citations

The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration

1991 • 252 citations

Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin- insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation

1987 • 249 citations

Patterns of aberrant sprouting in alzheimer's disease

1991 • 241 citations

Vitronectin and thrombospondin promote retinal neurite outgrowth: Developmental regulation and role of integrins

1991 • 237 citations

Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro

1989 • 225 citations

The structure of human platelet thrombospondin.

1985 • 222 citations

Glial changes following an excitotoxic lesion in the CNS—I. Microglia/macrophages

1991 • 215 citations

Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo.

1988 • 212 citations

Microglia and cell death in the developing mouse cerebellum

1990 • 212 citations

Monocytes and macrophages synthesize and secrete thrombospondin

1985 • 208 citations

Regeneration and retrograde degeneration of axons in the rat optic nerve

1982 • 205 citations

The distribution of microglia and cell death in the fetal rat forebrain

1991 • 197 citations

Basic FGF in astroglial, microglial, and neuronal cultures: characterization of binding sites and modulation of release by lymphokines and trophic factors

1992 • 192 citations

Cytotoxic Effect of Brain Macrophages on Developing Neurons

1991 • 191 citations

Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation.

1987 • 182 citations

First appearance, distribution, and origin of macrophages in the early development of the avian central nervous system

1993 • 181 citations

The Origin and Nature of Microglia

1981 • 178 citations

Senile plaques as aberrant sprout-stimulating structures

1986 • 161 citations

Transitory macrophages in the white matter of the developing visual cortex. II. Development and relations with axonal pathways

1983 • 148 citations

Microglial conditioned medium promotes survival and development of cultured mesencephalic neurons from embryonic rat brain

1993 • 146 citations

Cloning of human GAP 43: Growth association and ischemic resurgence

1988 • 138 citations

Production of basic fibroblast growth factor in cultured rat brain microglia

1991 • 127 citations

Deposition and role of thrombospondin in the histogenesis of the cerebellar cortex.

1990 • 118 citations

Thrombospondin and a 140 kd fragment promote adhesion and neurite outgrowth from embryonic central and peripheral neurons and from PC12 cells

1991 • 114 citations

Angiogenic macrophages produce the angiogenic inhibitor thrombospondin 1.

1993 • 111 citations

Human brain glial cells synthesize thrombospondin.

1986 • 110 citations

Influence of extracellular matrix proteins on the expression of neuronal polarity

1989 • 110 citations

Macrophage development: II. Early ontogeny of macrophage populations in brain, liver, and lungs of rat embryos as revealed by a lectin marker

1992 • 109 citations

Thrombospondin promotes process outgrowth in neurons from the peripheral and central nervous systems

1992 • 98 citations

Fibronectin and laminin regulate thein vitro differentiation of microglial cells

1991 • 98 citations

Rat mesencephalic neurons in culture exhibit different morphological traits in the presence of media conditioned on mesencephalic or striatal astroglia

1988 • 98 citations

Development of microglia in the albino rabbit retina

1989 • 83 citations

Immunohistochemical identification of thrombospondin in normal human brain and in Alzheimer's disease.

1992 • 64 citations

Neuronal interactions with the extracellular matrix

1991 • 50 citations

Thrombospondin expression in traumatized skeletal muscle

1990 • 33 citations

Characterization of the binding of thrombospondin to human platelets and its association with the platelet cytoskeleton.

1991 • 33 citations

Histochemical studies of the differentiation of microglial cells in the cerebral hemispheres of chick embryos and chicks

1987 • 29 citations

Role of thrombospondin in the adhesion of human endothelial cells in primary culture

1993 • 18 citations

The regulatory locus rλ1 affects the level of λl light chain synthesis in lipopolysaccharide‐activated lymphocytes but not the frequency of λl ‐positive B cell precursors

1985 • 11 citations