Oligodendrocytes and Myelin

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

1983 • 2,009 citations

Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult Rats

1981 • 1,679 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: An immunocytological study in the central nervous system

1981 • 1,131 citations

Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading.

1988 • 876 citations

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

1988 • 833 citations

A role for platelet-derived growth factor in normal gliogenesis in the central nervous system

1988 • 756 citations

Glial Cell Diversification in the Rat Optic Nerve

1989 • 725 citations

Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1

1984 • 723 citations

Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain

1993 • 714 citations

Multiple extracellular signals are required for long-term oligodendrocyte survival

1993 • 707 citations

Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro

1988 • 656 citations

MYELINATION IN RAT BRAIN: CHANGES IN MYELIN COMPOSITION DURING BRAIN MATURATION¹

1973 • 655 citations

FGF modulates the PDGF-driven pathway of oligodendrocyte development

1990 • 586 citations

Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells.

1990 • 573 citations

Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions

1993 • 556 citations

Inhibitors of Neurite Growth

1993 • 545 citations

CNTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor-Induced Death

1993 • 486 citations

Identification of an adult-specific glial progenitor cell

1989 • 476 citations

Myelin: Biology and Chemistry

1992 • 436 citations

Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1

1983 • 431 citations

Multiple and novel specificities of monoclonal antibodies O1, O4, and R‐mAb used in the analysis of oligodendrocyte development

1989 • 422 citations

Astrocytes Block Axonal Regeneration in Mammals by Activating the Physiological Stop Pathway

1987 • 400 citations

Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development.

1986 • 383 citations

Characterization of cloned cDNA representing rat myelin basic protein: Absence of expression in brain of shiverer mutant mice

1983 • 382 citations

The amino acid sequences of the myelin-associated glycoproteins: homology to the immunoglobulin gene superfamily

1987 • 370 citations

Insulin‐like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro

1988 • 361 citations

Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat.

1979 • 360 citations

Emergence of three myelin proteins in oligodendrocytes cultured without neurons.

1986 • 333 citations

Alternative splicing accounts for the four forms of myelin basic protein

1985 • 306 citations

Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan

1987 • 306 citations

Multiple Sclerosis

1993 • 284 citations

Evidence for the ventral origin of oligodendrocyte precursors in the rat spinal cord

1991 • 268 citations

Pre-oligodendrocytes from adult human CNS

1992 • 267 citations

Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions.

1989 • 266 citations

Differential myelinogenic capacity of specific developmental stages of the oligodendrocyte lineage upon transplantation into hypomyelinating hosts

1993 • 259 citations

Protocols for Neural Cell Culture

1993 • 251 citations

Proliferation and differentiation potential of rat forebrain oligodendroglial progenitors both in vitro and in vivo

1991 • 249 citations

Biochemical characterization of a putative axonal guidance molecule of the chick visual system

1990 • 241 citations

Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of O-2Aperinatal progenitor cells.

1992 • 230 citations

Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination.

1992 • 223 citations

Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex.

1993 • 221 citations

Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain.

1993 • 218 citations

Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titre to the myelin/oligodendrocyte glycoprotein (MOG)

1987 • 217 citations

Rat CNS white matter, but not gray matter, is nonpermissive for neuronal cell adhesion and fiber outgrowth

1989 • 214 citations

Immunochemical studies of myelin basic protein in shiverer mouse devoid of major dense line of myelin

1979 • 210 citations

Presence of the myelin-associated glycoprotein correlates with alterations in the periodicity of peripheral myelin.

1982 • 207 citations

The Isolation, Characterization, and Lipid-aggregating Properties of a Citrulline Containing Myelin Basic Protein

1989 • 206 citations

Embryonic divergence of oligodendrocyte and astrocyte lineages in developing rat cerebrum

1988 • 204 citations

The oligodendrocyte-type-2 astrocyte cell lineage is specialized for myelination

1986 • 201 citations

Basis of microheterogeneity of myelin basic protein.

1976 • 200 citations

Antibodies to myelin-oligodendrocyte glycoprotein in cerebrospinal fluid from patients with multiple sclerosis and controls

1991 • 196 citations

The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems.

1993 • 194 citations

GD3 ganglioside is a glycolipid characteristic of immature neuroectodermal cells

1984 • 193 citations

Nerve fiber growth in culture on tissue substrata from central and peripheral nervous systems

1987 • 190 citations

Identifying the protein products of brain-specific genes with antibodies to chemically synthesized peptides

1983 • 188 citations

Lineage of radial glia in the chicken optic tectum

1992 • 187 citations

Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen

1987 • 183 citations

Generation and migration of cells in the developing striatum

1992 • 183 citations

Spatial and temporal patterns of oligodendrocyte differentiation in rat cerebrum and cerebellum

1988 • 174 citations

Transplantation of oligodendrocytes and Schwann cells into the spinal cord of the myelin-deficient rat

1988 • 170 citations

Postnatal development of a brain-specific subspecies of protein kinase C in rat

1988 • 165 citations

The timely expression of myelin basic protein gene in cultured rat brain oligodendrocytes is independent of continuous neuronal influences

1985 • 158 citations

O2A progenitor cells transplanted into the neonatal rat brain develop into oligodendrocytes but not astrocytes.

1993 • 142 citations

Selective Expression of DM‐20, an Alternatively Spliced Myelin Proteolipid Protein Gene Product, in Developing Nervous System and in Nonglial Cells

1992 • 141 citations

Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus.

1987 • 141 citations

Morphology of astrocytes and oligodendrocytes during development in the intact rat optic nerve

1993 • 139 citations

Differentiation of cerebellar bipotential glial preecurosrs into oligodendrocytes in primary culture: Development profile of surface antigens and mitotic activity

1987 • 139 citations

Developmental regulation of myelin basic protein expression in mouse brain

1983 • 138 citations

Characterization of a slowly proliferative cell along the oligodendrocyte differentiation pathway.

1987 • 134 citations

Radioautographic evidence for slow astrocyte turnover and modest oligodendrocyte production in the corpus callosum of adult mice infused with3H-thymidine

1988 • 133 citations

Gliogenesis in rat optic nerve: Astrocytes are generated in a single wave before oligodendrocytes

1990 • 133 citations

Effects of acidic and basic fibroblast growth factors on proliferation and maturation of cultured rat oligodendrocytes

1989 • 133 citations

Identification of a cDNA coding for a fifth form of myelin basic protein in mouse.

1987 • 132 citations

The origin of remyelinating cells in the adult central nervous system: The role of the mature oligodendrocyte

1991 • 132 citations

Survival and differentiation of oligodendrocytes from neural tissue transplanted into new-born mouse brain

1983 • 132 citations

Cyclic AMP Induction of the Myelin Enzyme 2′,3′‐Cyclic Nucleotide 3′‐Phosphohydrolase in Rat Oligodendrocytes

1983 • 125 citations

Myelin-oligodendrocyte glycoprotein (MOG) is a surface marker of oligodendrocyte maturation

1989 • 123 citations

Cerebral white matter contains PDGF-responsive precursors to O2A cells

1990 • 121 citations

In vivo analysis of glial cell phenotypes during a viral demyelinating disease in mice.

1989 • 121 citations

Division of astroblasts and oligodendroblasts in postnatal rodent brain: Evidence for separate astrocyte and oligodendrocyte lineages

1991 • 120 citations

Oligodendrocyte Adhesion Activates Protein Kinase C-Mediated Phosphorylation of Myelin Basic Protein

1986 • 117 citations

Basic Protein in Brain Myelin Is Phosphorylated by Endogenous Phospholipid-Sensitive Ca²⁺-Dependent Protein Kinase

1982 • 116 citations

In vitro analysis of the oligodendrocyte lineage in mice during demyelination and remyelination.

1990 • 111 citations

Two developmentally regulated messenger RNAs differing in their coding region may exist for the myelin-associated glycoprotein.

1984 • 105 citations

Effect of bovine basic protein charge microheterogeneity on protein-induced aggregation of unilamellar vesicles containing a mixture of acidic and neutral phospholipids

1985 • 103 citations

Gliogenesis of astrocytes and oligodendrocytes in the neocortical grey and white matter of the adult rat: Electron microscopic analysis of light radioautographs

1980 • 101 citations

Membrane interactions in nerve myelin: II. Determination of surface charge from biochemical data

1988 • 100 citations

Novel stage in the oligodendrocyte lineage defined by reactivity of progenitors with R‐mAb prior to O1 anti‐galactocerebroside

1992 • 93 citations

Membrane proteins as reverse micelles: myelin basic protein in a membrane-mimetic environment

1985 • 88 citations

Long-term culture of human oligodendrocytes

1983 • 88 citations

Oligodendrocyte- and myelin-associated inhibitors of neurite outgrowth: Their involvement in the lack of CNS regeneration

1992 • 86 citations

Demyelination in a transgenic mouse: A model for multiple sclerosis

1993 • 85 citations

Membrane interactions in nerve myelin. I. Determination of surface charge from effects of pH and ionic strength on period

1988 • 85 citations

Oligodendroglial Expression and Deposition of Four Major Myelin Constituents in the Myelin Sheath during Development

1986 • 85 citations

Differential splicing of MAG transcripts during CNS and PNS development

1988 • 83 citations

The proteoglycan chondroitin sulfate is present in a subpopulation of cultured astrocytes and in their precursors

1987 • 82 citations

Antigen expression by glial cells grown in culture

1985 • 80 citations

Remyelination in the Human Central Nervous System

1989 • 80 citations

Can oligodendrocytes attached to myelin proliferate?

1988 • 77 citations

The initial events in myelin synthesis: orientation of proteolipid protein in the plasma membrane of cultured oligodendrocytes.

1989 • 76 citations

Multiple sclerosis. Interactions between oligodendrocytes and hypertrophic astrocytes and their occurrence in other, nondemyelinating conditions.

1992 • 76 citations

Immunosuppression promotes CNS remyelination in chronic virus‐induced demyelinating disease

1992 • 75 citations

Oligodendrocyte maturation and myelin gene expression in PDGF-treated cultures from rat cerebral white matter

1993 • 75 citations

Hydrophobic and electrostatic interactions of myelin basic protein with lipid. Participation of N-terminal and C-terminal portions

1981 • 75 citations

Regulation of oligodendrocyte differentiation

1992 • 74 citations

Evidence for the expression of four myelin basic protein variants in the developing human spinal cord through cDNA cloning

1987 • 73 citations

The inhibition of oligodendrocytic differentiation of O‐2A progenitors caused by basic fibroblast growth factor is overridden by astrocytes

1993 • 72 citations

Growth factors for human glial cells in culture

1988 • 70 citations

Interaction of astrocytes and newly formed oligodendrocytes in resolving multiple sclerosis lesions.

1990 • 67 citations

Protein kinase C activity modulates myelin gene expression in enriched oligodendrocytes

1993 • 64 citations

Astrocytes cultured from mature brain derive from glial precursor cells

1989 • 61 citations

Induction of oligodendrocyte proliferation and remyelination after chronic demyelination. Relevance to multiple sclerosis.

1988 • 59 citations

A Multidisciplinary Approach to Myelin Diseases

1987 • 59 citations

Phorbol ester enhances morphological differentiation of oligodendrocytes in culture

1988 • 58 citations

A New Family of Transcripts of the Myelin Basic Protein Gene: Expression in Brain and in Immune System

1993 • 57 citations

O‐2A glial progenitors from mature brain respond to CNS neuronal cell line‐derived growth factors

1991 • 55 citations

Tissue and species distribution and developmental variation of specific receptors for biologically active phorbol and ingenol esters

1981 • 54 citations

cDNA cloning and amino acid sequence for human myelin-associated glycoprotein

1989 • 52 citations

TRIPHOSPHOINOSITIDE PHOSPHODIESTERASE IN DEVELOPING BRAIN OF THE RAT AND IN SUBCELLULAR FRACTIONS OF BRAIN

1970 • 51 citations

Oligodendrocyte differentiation and progenitor cell proliferation are independently regulated by cyclic AMP

1993 • 49 citations

Proteolipid proteins: structure and genetic expression in normal and myelin-deficient mutant mice.

1989 • 47 citations

Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors.

1988 • 47 citations

Stimulation of phosphoinositide hydrolysis in myelin by muscarinic agonist and potassium

1987 • 46 citations

Protein kinase C in cultured adult human oligodendrocytes: A potential role for isoform α as a mediator of process outgrowth

1994 • 46 citations

Myelin development in infant brain

1984 • 46 citations

Early Myelination in the Human Fetal Lumbosacral Spinal Cord

1992 • 46 citations

Myelin swelling and measurement of forces between myelin membranes

1979 • 45 citations

Identification of GTP‐ binding proteins in myelin and oligodendrocyte membranes

1990 • 44 citations

Age‐dependent decrease of process formation by cultured oligodendrocytes is augmented by protein kinase C stimulation

1991 • 43 citations

A Novel Transcript Overlapping the Myelin Basic Protein Gene

1992 • 43 citations

Transient reversion of O4⁺ Galc⁻ oligodendrocyte progenitor development in response to the phorbol ester TPA

1993 • 41 citations

The N terminus of human myelin basic protein consists of C2, C4, C6, and C8 alkyl carboxylic acids.

1992 • 41 citations

Radio sensitivity of glial progenitor cells of the perinatal and adult rat optic nerve studied by an in vitro clonogenic assay

1991 • 41 citations

Differential expression of protein kinase C isozymes in rat glial cell cultures

1991 • 41 citations

Localization of basic proteins in human myelin

1993 • 40 citations

The human myelin-basic-protein gene: chromosomal localization and RFLP analysis.

1987 • 38 citations

Is the myelin membrane abnormal in multiple sclerosis?

1984 • 37 citations

Radial component of CNS myelin: Junctional subunit structure and supramolecular assembly

1990 • 36 citations

Myelin basic protein binds GTP at a single site in the N-terminus

1988 • 34 citations

Myelin‐associated glycoprotein is phosphorylated by protein kinase C

1993 • 33 citations

Reactive glial cells in CNS demyelination contain both GC and GFAP

1987 • 31 citations

A 57-kDa phosphatidylinositol-specific phospholipase C from bovine brain

1991 • 30 citations

Oligodendrocyte-type 2 astrocyte (O-2A) progenitor cells from neonatal and adult rat optic nerve differ in their responsiveness to platelet-derived growth factor

1990 • 28 citations

Neurite growth inhibition by CNS myelin proteins: A mechanism to confine fiber tracts?

1989 • 27 citations

Source of remyelinating oligodendrocytes.

1993 • 26 citations

Evolving Concepts and Issues in Remyelination

1989 • 26 citations

Oligodendrocyte‐substratum adhesion activates the synthesis of specific lipid species involved in cell signaling

1992 • 25 citations

Cellular and molecular biology of myelination

1991 • 24 citations

Modulation of antigenic expression in cultured adult human oligodendrocytes by derivatives of adenosine 3′,5′-cyclic monophosphate

1985 • 24 citations

Myelin formation in myelin-deficient rat spinal cord following transplantation of normal fetal spinal cord

1989 • 18 citations

An observation about myelination

1983 • 10 citations