The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity

1966 • 1,604 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.

1966 • 1,274 citations

Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.

1996 • 1,206 citations

The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor.

1994 • 990 citations

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration.

1990 • 857 citations

Roles of nitric oxide in tumor growth.

1995 • 791 citations

Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

1998 • 785 citations

Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer.

2000 • 691 citations

Nitric oxide synthase activity in human breast cancer

1995 • 637 citations

Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.

1996 • 555 citations

Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma

1997 • 537 citations

Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice.

1994 • 488 citations

Die krankhaften Geschwülste

1978 • 482 citations

Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast

1999 • 446 citations

Angiostatin-converting Enzyme Activities of Human Matrilysin (MMP-7) and Gelatinase B/Type IV Collagenase (MMP-9)

1997 • 430 citations

Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion.

1993 • 428 citations

Biology of the Macrophage

1986 • 416 citations

Macrophage responses to hypoxia: relevance to disease mechanisms

1999 • 391 citations

PR39, a peptide regulator of angiogenesis

2000 • 383 citations

Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas

2000 • 380 citations

Role of interferon-gamma in immune cell regulation.

1995 • 374 citations

Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity

1996 • 364 citations

Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha.

2000 • 360 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survival.

2000 • 339 citations

Activity of type IV collagenases in benign and malignant breast disease

1993 • 337 citations

Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1

1999 • 321 citations

The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer.

1995 • 314 citations

Role of interferon-γ in immune cell regulation

1995 • 295 citations

Macrophage Infiltration and Heme Oxygenase-1 Expression Correlate with Angiogenesis in Human Gliomas

2001 • 278 citations

Prognostic value of tumor‐associated macrophage count in human bladder cancer

2000 • 273 citations

Reduced infiltration of tumor-associated macrophages in human prostate cancer: association with cancer progression.

2000 • 267 citations

Expression of the M-CSF (CSF-1) gene by human monocytes

1987 • 238 citations

Vascular Permeability Factor, Fibrin, and the Pathogenesis of Tumor Stroma Formationa

1992 • 235 citations

Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.

1996 • 231 citations

Anti-Colony-Stimulating Factor-1 Antibody Staining in Primary Breast Adenocarcinomas Correlates With Marked Inflammatory Cell Infiltrates and Prognosis

1994 • 226 citations

Identification of Monocyte Chemotactic Activity Produced by Malignant Cells

1989 • 213 citations

High Expression of Macrophage Migration Inhibitory Factor in Human Melanoma Cells and Its Role in Tumor Cell Growth and Angiogenesis

1999 • 211 citations

Cytokine networks in solid human tumors: regulation of angiogenesis

1994 • 209 citations

The macrophage – a novel system to deliver gene therapy to pathological hypoxia

2000 • 208 citations

Tumor-associated macrophages in neoplastic progression: a paradigm for the in vivo function of chemokines.

1994 • 205 citations

The Toxicology of Interleukin-12: A Review

1999 • 204 citations

Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions.

1993 • 192 citations

Tumor infiltrating cells in human cancer. On the possible role of CD16+ macrophages in antitumor cytotoxicity.

1992 • 192 citations

Identification of Vascular Endothelial Growth Factor (VEGF) Receptor-2 (Flk-1) Promoter/Enhancer Sequences Sufficient for Angioblast and Endothelial Cell-Specific Transcription in Transgenic Mice

1999 • 183 citations

Inhibitors of nitric oxide synthase selectively reduce flow in tumour‐associated neovasculature

1992 • 179 citations

Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas

1997 • 178 citations

Changes in mechanisms of monocyte/macrophage-mediated cytotoxicity during culture. Reactive oxygen intermediates are involved in monocyte-mediated cytotoxicity, whereas reactive nitrogen intermediates are employed by macrophages in tumor cell killing.

1993 • 173 citations

Expression and activity of MMPS and their regulators in ovarian cancer

1994 • 168 citations

Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas

1999 • 165 citations

CSF-1 and Its Receptor in Ovarian, Endometrial and Breast Cancer

1995 • 161 citations

Intratumoral Coinjection of Two Adenoviruses, One Encoding the Chemokine IFN-γ-Inducible Protein-10 and Another Encoding IL-12, Results in Marked Antitumoral Synergy

2000 • 159 citations

Adoptive immunotherapy of cancer using monocyte-derived macrophages: rationale, current status, and perspectives

1998 • 157 citations

L-arginine-dependent reactive nitrogen intermediates as mediators of tumor cell killing by activated macrophages.

1990 • 155 citations

Clinical implications of expression of interleukin 8 related to angiogenesis in uterine cervical cancers.

2000 • 154 citations

Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis.

1996 • 151 citations

Defective Expression of the Monocyte Chemotactic Protein-1 Receptor CCR2 in Macrophages Associated with Human Ovarian Carcinoma

2000 • 141 citations

Intracellular distribution of macrophage migration inhibitory factor predicts the prognosis of patients with adenocarcinoma of the lung

2000 • 140 citations

Enhanced expression of macrophage migration inhibitory factor in prostatic adenocarcinoma metastases

1996 • 139 citations

Overexpression of epithelial macrophage colony-stimulating factor (CSF-1) and CSF-1 receptor: a poor prognostic factor in epithelial ovarian cancer, contrasted with a protective effect of stromal CSF-1.

1997 • 137 citations

Angiogenin expression in human colorectal cancer: the role of focal macrophage infiltration.

2000 • 125 citations

Urokinase and macrophages in tumour angiogenesis

1995 • 121 citations

Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1β

2000 • 120 citations

Potent antitumor effects mediated by local expression of the mature form of the interferon-γ inducing factor, interleukin-18 (IL-18)

1999 • 118 citations

Hypoxia inhibits macrophage migration

1999 • 117 citations

Macrophage migration inhibitory factor induces phagocytosis of foreign particles by macrophages in autocrine and paracrine fashion

1997 • 117 citations

Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: impact on tumour neoangiogenesis and survival

1998 • 114 citations

Phenotype and functions of intratumoral macrophages

1986 • 105 citations

Human macrophage metalloelastase gene expression in colorectal carcinoma and its clinicopathologic significance

2001 • 100 citations

M‐CSF (monocyte colony stimulating factor) and M‐CSF receptor expression by breast tumour cells: M‐CSF mediated recruitment of tumour infiltrating monocytes?

1992 • 100 citations

Angiogenesis and inflammation in invasive carcinoma of the breast.

1997 • 98 citations

Repopulation of γ-irradiated Lewis lung carcinoma by malignant cells and host macrophage progenitors

1978 • 96 citations

Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12

1999 • 94 citations

Role of Matrix Metalloproteinases in Colorectal Carcinogenesis

2001 • 84 citations

The mononuclear cell infiltrate compared with survival in high-grade astrocytomas

1989 • 82 citations

Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12

1999 • 79 citations

The role of leukocytes in the activation of blood coagulation.

1992 • 78 citations

Cells producing cathepsins D, B, and L in human breast carcinoma and their association with prognosis

2000 • 78 citations

Cytokine Gene Therapy of Cancer Using Interleukin‐12: Murine and Clinical Trials

1996 • 72 citations

Differential expression of the monocyte chemoattractant protein-1 gene in human papillomavirus-16-infected squamous intraepithelial lesions and squamous cell carcinomas of the cervix uteri.

1996 • 70 citations

Urokinase plasminogen activator receptor (CD87) expression of tumor-associated macrophages in ductal carcinoma in situ, breast cancer, and resident macrophages of normal breast tissue

1999 • 69 citations

Differing expression of MMPs-1 and -9 and urokinase receptor between diffuse- and intestinal-type gastric carcinoma

1999 • 66 citations

Induction of reactive oxygen intermediates in human monocytes by tumour cells and their role in spontaneous monocyte cytotoxicity

1999 • 66 citations

Expression and activity of matrix metalloproteases in human malignant mesothelioma cell lines

2001 • 63 citations

Monoclonal antibody (Y1/82A) with specificity towards peripheral blood monocytes and tissue macrophages.

1988 • 57 citations

Implications of Human Macrophage Metalloelastase and Vascular Endothelial Growth Factor Gene Expression in Angiogenesis of Hepatocellular Carcinoma

2000 • 56 citations

Tumour-associated macrophages in breast cancer and their prognostic correlations

1998 • 54 citations

Phase I trial of adoptive immunotherapy of cancer patients using monocyte-derived macrophages activated with interferon γ and lipopolysaccharide

1997 • 52 citations

Partial regression in primary carcinoma of the lung: does it occur?

1998 • 52 citations

Transforming growth factor-beta stimulates urokinase expression in tumor-associated macrophages of the breast.

1998 • 49 citations

Expression of monocyte chemoattractant protein-1 in meningioma

1995 • 47 citations

Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: Possible involvement of TNFα and IL-1α

2000 • 47 citations

Control of the antitumoral activity of human macrophages produced in large amounts in view of adoptive transfer

1988 • 45 citations

Macrophages and Microvessel Density in Tumors of the Ovary

1999 • 45 citations

Induction of Chemokine Secretion and Enhancement of Contact-Dependent Macrophage Cytotoxicity by Engineered Expression of Granulocyte-Macrophage Colony-Stimulating Factor in Human Colon Cancer Cells

2000 • 45 citations

Cytokine regulation of human monocyte differentiation in vitro: the tumor-cytotoxic phenotype induced by macrophage colony-stimulating factor is developmentally regulated by gamma-interferon.

1993 • 43 citations

Human recombinant migration inhibitory factor activates human macrophages to kill tumor cells

1992 • 39 citations

Phase I/II trial of autologous activated macrophages in advanced colorectal cancer

1996 • 39 citations

Human tumour-associated macrophages differentiate into osteoclastic bone-resorbing cells

1998 • 37 citations

Antitumor and Antimetastatic Activity of lnterleukin-12

1996 • 35 citations

Induction of potent antitumor response by vaccination with tumor lysate-pulsed macrophages engineered to secrete macrophage colony-stimulating factor and interferon-γ

2000 • 28 citations

Monocyte chemoattractant protein-1 (MCP-1) expression in primary lymphoepithelioma-like carcinomas (LELCs) of the lung

1998 • 27 citations

Endothelial and macrophage upregulation of urokinase receptor expression in human renal cell carcinoma

1997 • 27 citations

Priming of human monocyte superoxide production and arachidonic acid metabolism by adherence to collagen- and basement membrane–coated surfaces

1994 • 27 citations

Suppression of the reactive oxygen intermediates production of human macrophages by colorectal adenocarcinoma cell lines

1999 • 27 citations

Cytotoxicity of cancer patient's macrophages for tumor cells

1982 • 23 citations

Treatment of Metastatic Renal Cell Carcinoma With Activated Autologous Macrophages and Granulocyte–Macrophage Colony-Stimulating Factor

2000 • 23 citations

EXPRESSION OF CATHEPSIN D IN TRANSITIONAL CELL BLADDER TUMOURS

1996 • 21 citations

Autologous tumor killing and natural cytotoxic activity of tumor-associated macrophages in cancer patients

1985 • 16 citations

6 Growth factors in haemopoiesis

1989 • 15 citations

Immune control of neoplasia by adoptive transfer of macrophages: potentiality for antigen presentation and gene transfer.

1994 • 12 citations

The role of vascular endothelial growth factor in the regulation of blood vessel growth

1997 • 11 citations

Enhancement of Anti-Tumor Immunity by Injection of Fibroblasts Genetically Engineered to Produce IL-12 and to Express CD70

1998 • 9 citations

Tumoricidal potential of human macrophages grown in vitro from blood monocytes.

1996 • 7 citations