Intratumoral Coinjection of Two Adenoviruses, One Encoding the Chemokine IFN-γ-Inducible Protein-10 and Another Encoding IL-12, Results in Marked Antitumoral Synergy

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

Construction of adenovirus vectors through Cre-lox recombination

1997 • 807 citations

Mig and IP-10: CXC chemokines that target lymphocytes

1997 • 802 citations

Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

1998 • 785 citations

Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells.

1993 • 755 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.

1995 • 710 citations

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1996 • 480 citations

Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis.

1995 • 459 citations

The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation.

1995 • 456 citations

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

1998 • 449 citations

IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo.

1993 • 414 citations

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product.

1996 • 386 citations

NK1.1 Cells Express 4-1BB (CDw137) Costimulatory Molecule and Are Required for Tumor Immunity Elicited by Anti-4-1BB Monoclonal Antibodies

1998 • 361 citations

Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization

1998 • 340 citations

The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice.

1991 • 306 citations

Activation of NK cells by CC chemokines. Chemotaxis, Ca2+ mobilization, and enzyme release.

1996 • 284 citations

Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.

1996 • 231 citations

Establishment of mouse colonic carcinoma cell lines with different metastatic properties.

1980 • 228 citations

Interferon-inducible protein-10 identified as a mediator of tumor necrosisin vivo

1996 • 223 citations

Combined chemokine and cytokine gene transfer enhances antitumor immunity

1996 • 215 citations

Binding and Functional Properties of Recombinant and Endogenous CXCR3 Chemokine Receptors

1998 • 212 citations

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product

1996 • 206 citations

The Toxicology of Interleukin-12: A Review

1999 • 204 citations

Contribution of Natural Killer Cells to Inhibition of Angiogenesis by Interleukin-12

1999 • 192 citations

T cell costimulation by B7/BB1 induces CD8 T cell-dependent tumor rejection: an important role of B7/BB1 in the induction, recruitment, and effector function of antitumor T cells.

1994 • 174 citations

Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine.

1990 • 172 citations

Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12

1999 • 151 citations

Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12

1998 • 151 citations

Gene Transfer as Cancer Therapy

1995 • 142 citations

Genomic characterization of a gamma-interferon-inducible gene (IP-10) and identification of an interferon-inducible hypersensitive site.

1987 • 137 citations

A Role for the Interferon‐Inducible Protein 10 in Inhibition of Angiogenesis by Interleukin‐12

1996 • 115 citations

A macrophage LPS-inducible early gene encodes the murine homologue of IP-10

1990 • 114 citations

The chemokine SDF-1α triggers a chemotactic response and induces cell polarization in human B lymphocytes

1998 • 108 citations

Adenoviral Vectors Expressing Lymphotactin and Interleukin 2 or Lymphotactin and Interleukin 12 Synergize to Facilitate Tumor Regression in Murine Breast Cancer Models

1999 • 105 citations

Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12

1999 • 94 citations

Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase

1995 • 91 citations

Engineering of immunogenic peptides by co‐linear synthesis of determinants recognized by B and T cells

1987 • 88 citations

Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16

1997 • 83 citations

Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12

1999 • 79 citations

Gene Transfer and Therapy with Adenoviral Vector in Rats with Diethylnitrosamine-Induced Hepatocellular Carcinoma

1997 • 75 citations

Cytokine Gene Therapy of Cancer Using Interleukin‐12: Murine and Clinical Trials

1996 • 72 citations

Adenoviral Gene Transfer of Interleukin 12 into Tumors Synergizes with Adoptive T Cell Therapy Both at the Induction and Effector Level

2000 • 61 citations

Immunomodulatory Functions and Molecular Regulation of IL-12

1997 • 54 citations

Genomic Characterization of a Gamma-Interferon-Inducible Gene (IP-1O) and Identification of an Interferon-Inducible Hypersensitive Site

1987 • 42 citations

Cloning of the Murine Interferon-Inducible Protein 10 (IP-10) Receptor and Its Specific Expression in Lymphoid Organs

1998 • 29 citations

A mechanism for selective recruitment of CD8 T cells into B7-1-transfected plasmacytoma: role of macrophage-inflammatory protein 1alpha.

1997 • 29 citations

Enhancement of Anti-Tumor Immunity by Injection of Fibroblasts Genetically Engineered to Produce IL-12 and to Express CD70

1998 • 9 citations