FoxO1 Regulates Multiple Metabolic Pathways in the Liver

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Primer3 on the WWW for General Users and for Biologist Programmers

2003 • 15,242 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

2004 • 2,779 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

2004 • 1,836 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction

2003 • 1,399 citations

FOXO transcription factors at the interface between longevity and tumor suppression

2005 • 1,250 citations

Unified nomenclature for the winged helix/forkhead transcription factors

2000 • 1,136 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

2005 • 945 citations

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

2001 • 907 citations

Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)

2001 • 850 citations

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

1999 • 771 citations

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

1999 • 727 citations

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

2004 • 721 citations

Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway

2004 • 660 citations

Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c

2002 • 653 citations

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

2002 • 616 citations

FoxO proteins in insulin action and metabolism

2005 • 589 citations

cell cycle and death control: long live Forkheads

2002 • 583 citations

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

1999 • 542 citations

Insulin-like Growth Factor Binding Protein-1: Recent Findings and New Directions

1997 • 532 citations

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver

2004 • 527 citations

JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16

2005 • 514 citations

Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes

2004 • 412 citations

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

1999 • 396 citations

Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver

2003 • 375 citations

Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats

1976 • 357 citations

Transcriptional feedback control of insulin receptor by dFOXO/FOXO1

2005 • 354 citations

Cloning and Characterization of Three Human Forkhead Genes That Comprise an FKHR-like Gene Subfamily

1998 • 350 citations

The interaction between FOXO and SIRT1: tipping the balance towards survival

2004 • 339 citations

Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR

2000 • 339 citations

Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation

2003 • 323 citations

SREBPs suppress IRS-2-mediated insulin signalling in the liver

2004 • 310 citations

Foxo1 mediates insulin action on apoC-III and triglyceride metabolism

2004 • 263 citations

Foxo1 mediates insulin action on apoC-III and triglyceride metabolism

2004 • 250 citations

Coordinated Regulation of Fat-Specific and Liver-Specific Glycerol Channels, Aquaporin Adipose and Aquaporin 9

2002 • 240 citations

Hepatic Nuclear Factor 3- and Hormone-Regulated Expression of the Phosphoenolpyruvate Carboxykinase and Insulin-Like Growth Factor-Binding Protein 1 Genes

1995 • 226 citations

Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms

2004 • 224 citations

Convergence of Peroxisome Proliferator-activated Receptor γ and Foxo1 Signaling Pathways

2003 • 224 citations

The Forkhead Transcription Factor AFX Activates Apoptosis by Induction of the BCL-6 Transcriptional Repressor

2002 • 222 citations

Expressionof Drosophila FOXO regulates growth and can phenocopy starvation

2003 • 220 citations

Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

2003 • 202 citations

Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice

2004 • 189 citations

Phenotypic Modulation of Smooth Muscle Cells through Interaction of Foxo4 and Myocardin

2005 • 189 citations

Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt

2000 • 184 citations

Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span

2001 • 174 citations

PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

2003 • 173 citations

Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence

1998 • 164 citations

FoxO3a and BCR-ABL Regulatecyclin D2Transcription through a STAT5/BCL6-Dependent Mechanism

2004 • 162 citations

Human aquaporin adipose (AQPap) gene

2002 • 154 citations

PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

2003 • 148 citations

FoxO1 Stimulates Fatty Acid Uptake and Oxidation in Muscle Cells through CD36-dependent and -independent Mechanisms

2005 • 147 citations

FKHR Binds the Insulin Response Element in the Insulin-Like Growth Factor Binding Protein-1 Promoter*

1999 • 146 citations

Glucose as a regulator of eukaryotic gene transcription

2005 • 145 citations

Molecular Mechanisms of Insulin Resistance in IRS-2-Deficient Hepatocytes

2003 • 143 citations

Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements

2004 • 141 citations

A forkhead transcription factor FKHR up‐regulates lipoprotein lipase expression in skeletal muscle

2003 • 129 citations

Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt

2000 • 125 citations

Gene- and Activation-specific Mechanisms for Insulin Inhibition of Basal and Glucocorticoid-induced Insulin-like Growth Factor Binding Protein-1 and Phosphoenolpyruvate Carboxykinase Transcription

2001 • 115 citations

Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.

1999 • 112 citations

Fulminant hepatic failure in murine hepatitis virus strain 3 infection: tissue-specific expression of a novel fgl2 prothrombinase

1997 • 109 citations

The Transcription Factors HIF-1 and HNF-4 and the Coactivator p300 Are Involved in Insulin-regulated Glucokinase Gene Expression via the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

2004 • 108 citations

Hepatocyte Nuclear Factor-4 Is a Novel Downstream Target of Insulin via FKHR as a Signal-regulated Transcriptional Inhibitor

2003 • 99 citations

Insulin Inhibits Hepatocellular Glucose Production by Utilizing Liver-enriched Transcriptional Inhibitory Protein to Disrupt the Association of CREB-binding Protein and RNA Polymerase II with the Phosphoenolpyruvate Carboxykinase Gene Promoter

2002 • 99 citations

Hepatocyte Nuclear Factor-3 (HNF-3) Binds to the Insulin Response Sequence in the IGF Binding Protein-1 (IGFBP-1) Promoter and Enhances Promoter Function

1994 • 91 citations

The Forkhead Transcription Factor FOXO4 Induces the Down-regulation of Hypoxia-inducible Factor 1α by a von Hippel-Lindau Protein-independent Mechanism

2003 • 86 citations

Insulin Regulation of Gene Expression through the Forkhead Transcription Factor Foxo1 (Fkhr) Requires Kinases Distinct from Akt

2001 • 81 citations

Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver, and pituitary.

1991 • 79 citations

Insulin-induced Activation of Atypical Protein Kinase C, but Not Protein Kinase B, Is Maintained in Diabetic (ob/ob and Goto-Kakazaki) Liver

2004 • 79 citations

SREBP-1c and Sp1 Interact to Regulate Transcription of the Gene for Phosphoenolpyruvate Carboxykinase (GTP) in the Liver

2004 • 68 citations

The cyclic adenosine 3',5'-monophosphate- and the glucocorticoid-dependent enhancers are targets for insulin repression of tyrosine aminotransferase gene transcription.

1994 • 61 citations

Liver Glucokinase Can Be Activated by Peroxisome Proliferator-Activated Receptor-γ

2004 • 52 citations

Overexpression of the Acid-Labile Subunit of the IGF Ternary Complex in Transgenic Mice

2001 • 30 citations

Glucose-induced lipogenesis in pancreatic β-cells is dependent on SREBP-1

2005 • 25 citations

Insulin Response Sequence-Dependent and -Independent Mechanisms Mediate Effects of Insulin on Glucocorticoid-Stimulated Insulin-Like Growth Factor Binding Protein-1 Promoter Activity

2005 • 15 citations

Lillie's Oil Red O Method For Neutral Lipids

1999 • 12 citations

Role of Three FKHR Phosphorylation Sites in Insulin Inhibition of FKHR Action in Hepatocytes

2001 • 7 citations