Convergence of Peroxisome Proliferator-activated Receptor γ and Foxo1 Signaling Pathways

Arzneimittelforschung

2005 • 8,820 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

1999 • 1,963 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction

2003 • 1,399 citations

The Endocrine Regulation of Aging by Insulin-like Signals

2003 • 1,342 citations

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

1999 • 1,339 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Sublines of mouse 3T3 cells that accumulate lipid

1974 • 918 citations

Minireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors

2003 • 864 citations

Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation.

1994 • 827 citations

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

1999 • 763 citations

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

1999 • 719 citations

The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation

2003 • 711 citations

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

2000 • 608 citations

Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

1989 • 587 citations

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

2001 • 570 citations

FOXC2 Is a Winged Helix Gene that Counteracts Obesity, Hypertriglyceridemia, and Diet-Induced Insulin Resistance

2001 • 549 citations

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

1999 • 542 citations

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

2001 • 517 citations

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

2001 • 494 citations

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

2000 • 483 citations

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

1999 • 470 citations

The Many Forks in FOXO's Road

2003 • 425 citations

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

2000 • 367 citations

Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR

2000 • 339 citations

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling

1999 • 289 citations

Positive regulation of the peroxisomal β‐oxidation pathway by fatty acids through activation of peroxisome proliferator‐activated receptors (PPAR)

1993 • 284 citations

Regulation of Phosphoenolpyruvate Carboxykinase and Insulin-like Growth Factor-binding Protein-1 Gene Expression by Insulin

2000 • 277 citations

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

2001 • 266 citations

Suppression of Preadipocyte Differentiation and Promotion of Adipocyte Death by HIV Protease Inhibitors

2000 • 235 citations

Phosphatidylinositol 3-Kinase Signaling Inhibits DAF-16 DNA Binding and Function via 14-3-3-dependent and 14-3-3-independent Pathways

2001 • 217 citations

p300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor α

1997 • 174 citations

DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells

2000 • 169 citations

AKT-Independent Protection of Prostate Cancer Cells from Apoptosis Mediated through Complex Formation between the Androgen Receptor and FKHR

2002 • 160 citations

Forkhead Homologue in Rhabdomyosarcoma Functions as a Bifunctional Nuclear Receptor-interacting Protein with Both Coactivator and Corepressor Functions

2001 • 159 citations

Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals.

1990 • 155 citations

Ligand-dependent Interaction of Estrogen Receptor-α with Members of the Forkhead Transcription Factor Family

2001 • 147 citations

Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival

2000 • 135 citations

Role of Foxa-2 in adipocyte metabolism and differentiation

2003 • 128 citations

Molecular interaction of dihydropyridine receptors with type-1 ryanodine receptors in rat brain

2001 • 91 citations

Olf-1/Early B Cell Factor Is a Regulator ofglut4 Gene Expression in 3T3-L1 Adipocytes

2002 • 38 citations

Opposing early inhibitory and late stimulatory effects of insulin-like growth factor-I on myogenin gene transcription

2000 • 30 citations

Molecular Genetic Mechanisms of Life Span Manipulation in Caenorhabditis elegans

2000 • 28 citations

Characterization of Insulin Inhibition of Transactivation by a C-terminal Fragment of the Forkhead Transcription Factor Foxo1 in Rat Hepatoma Cells

2003 • 27 citations