Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

2004 • 3,100 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1999 • 2,199 citations

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

2001 • 2,042 citations

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

2004 • 1,896 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

2004 • 1,877 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

p53 mutant mice that display early ageing-associated phenotypes

2002 • 1,428 citations

Mammalian SIRT1 Represses Forkhead Transcription Factors

2004 • 1,352 citations

Decision making by p53: life, death and cancer

2003 • 1,055 citations

Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation

2004 • 1,008 citations

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

2001 • 907 citations

MDC1 is a mediator of the mammalian DNA damage checkpoint

2003 • 862 citations

IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a

2004 • 845 citations

cell cycle and death control: long live Forkheads

2002 • 583 citations

Modulation of mammalian life span by the short isoform of p53

2004 • 564 citations

Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance

2001 • 457 citations

The Molecular Basis of FHA Domain:Phosphopeptide Binding Specificity and Implications for Phospho-Dependent Signaling Mechanisms

2000 • 449 citations

The FHA Domain Is a Modular Phosphopeptide Recognition Motif

1999 • 395 citations

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

2003 • 332 citations

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway

2001 • 117 citations

Aging: New Targets, New Functions

2003 • 18 citations