JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16

THE GENETICS OF CAENORHABDITIS ELEGANS

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Signal Transduction by the JNK Group of MAP Kinases

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Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

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C. elegans: des neurones et des gènes

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The Nematode Caenorhabditis elegans

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

2003 • 2,209 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

2000 • 1,423 citations

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

2001 • 1,013 citations

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

2002 • 944 citations

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

2001 • 907 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

2003 • 644 citations

A Conserved Regulatory System for Aging

2001 • 526 citations

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans

2003 • 439 citations

JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila

2003 • 407 citations

C. elegans SGK-1 Is the Critical Component in the Akt/PKB Kinase Complex to Control Stress Response and Life Span

2004 • 357 citations

UNC-16, a JNK-Signaling Scaffold Protein, Regulates Vesicle Transport in C. elegans

2001 • 231 citations

Akt1 Regulates a JNK Scaffold during Excitotoxic Apoptosis

2002 • 206 citations

Stress resistance as a determinate of C. elegans lifespan

2002 • 206 citations

A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons

1999 • 109 citations

Insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans

2001 • 109 citations

A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses

2000 • 92 citations

Life span of the wild and mutant nematode Caenorhabditis elegans

1982 • 74 citations

jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans

2001 • 65 citations

Longevity and heat stress regulation in Caenorhabditis elegans

2003 • 61 citations

JNK-interacting Protein 1 Promotes Akt1 Activation

2003 • 59 citations

Insulin worms its way into the spotlight

2003 • 35 citations

Why only time will tell

2001 • 34 citations

Subfield History: Caenorhabditis elegans as a System for Analysis of the Genetics of Aging

2002 • 9 citations